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Within the software engineering community, deciding how to collect, store and use personal data has become about more than just understanding our users. This paper considers ethical data use that includes cultural considerations and data ownership rights. We discuss indigenous data sovereignty as a concept and how it potentially impacts technological solutions that gather personal data from users. We propose an extension to typical user-centred design processes, which we call participatory data design. This incorporates the use of frameworks and tools that specifically focus on managing data within the cultural context it is gathered from. We also present a specific example of how we have used this approach in the context of a data collection project from Māori workers in New Zealand forestry. We conclude with a discussion of the wider implications of this approach. [ABSTRACT FROM AUTHOR]

Wu, Howlett, and Ramesh's understanding of policy capacity has been used to identify generalizable strengths and weaknesses of specific jurisdictions and policy sectors such as health. In an extension of this work, Howlett and Ramesh have argued that the mode of governance of a policy sector accentuates the importance of specific elements of policy capacity. In this paper we focus on the implementation of the System Level Measures Framework (SLMF) in New Zealand that has been specifically focused on health systems improvement and which aimed to do so by fostering network governance at the local level. However, this policy is introduced in a context in which there has been significant contestation regarding which mode of governance--network or hierarchy--is dominant in New Zealand health policy. By exploring three divergent local cases of implementation of the SLMF we develop three arguments that contribute to the literature on policy capacity and health. Firstly, local histories of interorganizational play a crucial role in shaping health policy capacity. Secondly, it is crucially important to understand the dynamics and feedback loops between operational, political, and analytical policy capacity. Network and hierarchical governance are characterized by distinct and contrasting understandings of the content of policy capacity elements and of the way in which they are dynamically related. Thirdly, the key challenge in developing policy capacity compatible with network governance is how to facilitate this capacity when connections between operational, political, and analytical policy capacity fail to fire. [ABSTRACT FROM AUTHOR]

While the Sustainable Development Goals (SDGs) were inclusive in their design, the reliance on official measurement infrastructures has upheld narrow definitions of both the terms of sustainability and development. Indigenous and non-Indigenous "governance beyond the state" approaches call these definitions into question. They highlight that disaggregated official data are unable to fully reflect alternative grounds and aspirations of living sustainably with the environment and non-human world. Relational Indigenous epistemologies and practices contribute to alternative epistemic infrastructures. In this paper, three examples from the Andean-Pacific region provide an alternative lens through which to reconceptualize and remake the SDG landscape. Together this suite of cases highlights the importance of bottom-up articulation processes, knowledge inclusion, and alternative epistemic harmonization for operationalizing the SDGs. In particular, we highlight the urgent need to renegotiate the relationship between Indigenous communities and the global measurement infrastructure in order to pursue and realize sustainability globally. [ABSTRACT FROM AUTHOR]

Background Physical inactivity rates have remained high worldwide since 2001. Public policies are an essential upstream lever to target individual physical activity (PA) behaviour. However, implementers have different strategies and face implementation challenges that are poorly understood. The present study analyzes the implementation processes of public policies to promote PA in terms of: (i) the policies covered and their legal quality, (ii) the actors and stakeholders involved in the implementation process and (iii) the used implementation strategies (vertical, horizontal or a mix). Methods A scoping review was systematically conducted (registered Open Science Framework: osf.io/7w84q/), searching 10 databases and grey literature until March 2022. Of the 7741 titles and abstracts identified initially, 10 studies were included. Results The current evidence includes high-income countries (USA, n  = 7; UK, New Zealand and Oman, n  = 1 each). Policy areas covered are education (school sector) and PA promotion in general (national PA plans or city-wide approaches). The legal classification ranges from laws (school sector) to coordination and budgeting to non-legally binding recommendations. The jurisdictions covered were federal (n  = 4), state (n  = 1), county (n  = 1), school district (n  = 1) and city (n  = 3). Implementation strategies for city-wide approaches are characterized by a coordinated approach with vertical and horizontal integration; federal PA policies by a mix of implementation strategies; and the school sector by a strict horizontal top-down integration without the involvement of other actors. Conclusion Implementation strategies differ by policy field. Therefore, continuous evaluation of the implementation process is necessary to align policy implementation with policy goals to promote individual PA behaviour. [ABSTRACT FROM AUTHOR]

Background Emotional symptoms are recognized as a key feature in individuals with major depressive disorder. Previously, emotional blunting has been described both as a side effect of antidepressant treatment and as a symptom of depression. Little is known about the change of emotional blunting during antidepressant treatment. Methods The PREDDICT trial is a randomized, placebo-controlled, 6-week trial on the augmentation of vortioxetine with the anti-inflammatory agent celecoxib or placebo. Presently we report on exploratory secondary outcomes of changes in emotional blunting in depression assessed with the Oxford Depression Questionnaire (ODQ) total score and subscores from baseline to 8-week, 3-month, and 6-month follow-up assessments. Results In the whole group, there was a significant improvement in the ODQ total score and all subscores after 8 weeks. After stratification of participants into the treatment groups, the ODQ total score as well as subscores related to emotional blunting as a symptom of depression (reduction in positive emotions, not caring) improved between baseline and all follow-up time points in both treatment groups. Changes in subscores considered as a side effect of antidepressants (general reduction in emotions, emotional detachment) were inconclusive in both treatment groups. Overall, the placebo-augmented group showed slightly better results in changes of emotional blunting scores than the celecoxib group as did those with elevated inflammation at screening, regardless of treatment group. Conclusions This analysis suggests favorable effects of vortioxetine on emotional blunting in both short- and long-term course. The beneficial impact of vortioxetine on emotional blunting was weaker in celecoxib-augmented patients compared with placebo, possibly due to pharmacokinetic interactions. Clinical Trials Registration: Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN12617000527369p. Registered on 11 April 2017, http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12617000527369p. [ABSTRACT FROM AUTHOR]

Dynamic nonlinear elasticity in rocks may play an important role in earth processes, such as earthquake nucleation. In order to understand how nonlinear elasticity occurs within the shallow crust, experiments are required that simulate the in situ conditions of intact crustal rocks. Additionally, exploring the behaviour of nonlinear elasticity in response to changes in external parameters (e.g. temperature and wave frequency) acts as a means to further illuminate the complex mechanisms which give rise to nonlinear elasticity in rocks. In this study, we perform dynamic acoustoelastic testing (DAET) experiments on an intact cataclasite from the damage zone of the Alpine Fault, New Zealand. By performing pump-probe DAET experiments inside a temperature-controlled chamber, we are able to investigate a rich variety of nonlinear behaviour as a function of temperature. We find that the magnitude of average softening, cubic nonlinearity, and hysteresis tend to increase as temperature increases from 20 to 110 °C. In contrast, quadratic nonlinearity decreases with increasing temperature. These observations support the hypothesis that at least two distinct mechanisms control nonlinear phenomena in rocks. Nonlinear parameters show little to no dependence on frequency over the 200–600 Hz pump range, although values of the nonlinear parameter α are found to be nearly two orders of magnitude smaller than those determined using ultrasonic perturbations. Additionally, an analysis using different time windows shows that the surface waves of the ultrasonic probe sense greater nonlinearity compared to the direct P - wave due to differences in the polarization and propagation paths. As well as providing further insight into the mechanisms responsible for nonlinear elasticity in rocks, our experiments show that nonlinear softening will increase as temperature increases in the damage zones of faults. This has potential implications for understanding earthquake nucleation processes. [ABSTRACT FROM AUTHOR]

The dynamics of accretionary prisms and the processes that take place along subduction interfaces are controlled, in part, by the porosity and fluid overpressure of both the forearc wedge and the sediments transported to the system by the subducting plate. The Hikurangi Margin, located offshore the North Island of New Zealand, is a particularly relevant area to investigate the interplay between the consolidation state of incoming plate sediments, dewatering and fluid flow in the accretionary wedge and observed geodetic coupling and megathrust slip behaviour along the plate interface. In its short geographic extent, the margin hosts a diversity of properties that impact subduction processes and that transition from north to south. Its southernmost limit is characterized by frontal accretion, thick sediment subduction, the absence of seafloor roughness, strong interseismic coupling and deep slow slip events. Here we use seafloor magnetotelluric (MT) and controlled-source electromagnetic (CSEM) data collected along a profile through the southern Hikurangi Margin to image the electrical resistivity of the forearc and incoming plate. Resistive anomalies in the shallow forearc likely indicate the presence of gas hydrates, and we relate deeper forerarc resistors to thrust faulting imaged in colocated seismic reflection data. Because MT and CSEM data are highly sensitive to fluid phases in the pore spaces of seafloor sediments and oceanic crust, we convert resistivity to porosity to obtain a representation of fluid distribution along the profile. We show that porosity predicted by the resistivity data can be well fit by an exponential sediment compaction model. By removing this compaction trend from the porosity model, we are able to evaluate the second-order, lateral changes in porosity, an approach that can be applied to EM data sets from other sedimentary basins. Using this porosity anomaly model, we examine the consolidation state of the incoming plate and accretionary wedge sediments. A decrease in porosity observed in the sediments approaching the trench suggests that a protothrust zone is developing ∼25 km seaward of the frontal thrust. Our data also imply that sediments deeper in the accretionary wedge are slightly underconsolidated, which may indicate incomplete drainage and elevated fluid overpressures of the deep wedge. [ABSTRACT FROM AUTHOR]

Gas hydrates that occur on many continental margins have received global attention. In reflection seismic imaging, the bottom-simulating reflector (BSR) is a common indicator of gas hydrates. However, it is difficult to identify gas hydrates and quantify their amounts through the BSR alone. For gas-hydrate characterization, it is therefore useful to measure seismic stratigraphic and attenuation attributes. Short-scale patterns of layering that contain information about the amount and mechanism of gas hydrates can be identified through stratigraphic and attenuation attributes. We measure the complete time-variant spectra by using sparse strongest peaks, and the spectral differences at different times through attenuation parameters Q –1 and γ. The traditional Q –1 is associated with the attenuation of the frequency-dependent part of wavefield, and the γ characterizes the frequency-independent attenuation. The measurement approach is straightforward and requires no sophisticated inverse algorithm and is applied to surface seismic data acquired over the Hikurangi and Gondwana margins, eastern New Zealand. High-quality spectral and attenuation images are obtained. Spectral attributes correlate with BSRs and large positive Q –1 and negative γ -values are below and above the BSRs, which are interpreted as being related to free-gas and gas-hydrate accumulations. These results will aid the quantification of gas hydrates and the assessment of their roles as an energy resource, as a potential geological hazard, and in climate change and ocean warming. [ABSTRACT FROM AUTHOR]

In many situations, species distribution models need to make use of multiple data sources to address their objectives. We developed a spatio-temporal modelling framework that integrates research survey data and data collected by observers onboard fishing vessels while accounting for physical barriers (islands, convoluted coastlines). We demonstrated our framework for two bycatch species in New Zealand deepwater fisheries: spiny dogfish (Squalus acanthias) and javelinfish (Lepidorhynchus denticulatus). Results indicated that employing observer-only data or integrated data is necessary to map fish biomass at the scale of the New Zealand exclusive economic zone, and to interpolate local biomass indices (e.g. for the east coast of the South Island) in years with no survey but available observer data. Results also showed that, if enough survey data are available, fisheries analysts should: (1) develop both an integrated model and a model relying on survey-only data; and (2) for a given geographic area, ultimately choose the index produced with integrated data or the index produced with survey-only data based on the reliability of the interannual variability of the index. We also conducted a simulation experiment, which indicated that the predictions of our spatio-temporal models are virtually insensitive to the consideration of physical barriers. [ABSTRACT FROM AUTHOR]

Background Past studies have demonstrated better mental health and well-being among transgender youth who had accessed gender-affirming care. However, few existing studies have assessed unmet need for gender-affirming care as a social determinant of mental health inequities. Methods Data on unmet need for gender-affirming care, distress and suicidality were analysed from the 2018 Counting Ourselves nationwide community-based survey of transgender people in Aotearoa/New Zealand. Associations between unmet need for gender-affirming care and mental health indicators were tested for transgender youth within the sample (aged 14–26 years; n  = 608; M age = 20.5). Results Transgender youth reported unmet needs ranging from 42% for gender-affirming hormone to 100% for feminizing surgeries and voice surgeries. Overall unmet need for gender-affirming care was associated with worse mental health. Trans men with an unmet need for chest reconstruction (84%) scored an average of 7.13 points higher on the K10 Psychological Distress Scale relative to those whose need had been met. Participants reporting unmet need for hormones (42%) had twice the odds (adjusted odds ratios = 2.01; CI = 1.02–3.98) of having attempted suicide in the last 12 months. Conclusions Dismantling barriers to accessing gender-affirming care could play a crucial role in reducing mental health inequities faced by transgender youth. [ABSTRACT FROM AUTHOR]

Countries are rapidly developing digital contact tracing solutions to augment manual contact tracing. There is limited empirical evidence evaluating these tools. We conducted a feasibility study of a Bluetooth-enabled card with hospital staff in New Zealand (n  = 42). We compared the card data against self-report contact surveys and a stronger Bluetooth device. The cards detected substantially more contacts than self-report contact surveys, while the concordance between Bluetooth devices was high, suggesting that the cards detected clinically relevant close contacts. There was high acceptability among participants, suggesting that their integration would be accepted by healthcare staff. As the pandemic shifts, there is a need to rapidly contact trace and conduct informed risk management, particularly in critical settings such as healthcare. [ABSTRACT FROM AUTHOR]

Background Childhood cancer survivors are vulnerable to long-term treatment-related health conditions, which can lead to poor quality of life. Little data exist on the overall health of long-term Australian and New Zealand childhood cancer survivors or on survivors' motivations for attending survivorship clinics. Methods This study administers a cross-sectional questionnaire to long-term survivors ≥5 years from their primary diagnosis. We compared participant-reported number of late effects by a cancer diagnosis, and identified clinical (eg, treatment) and demographic (eg, age) factors that were associated with late effects burden and engagement in cancer survivorship care. Results A total of 634 participants completed questionnaires (48% male, mean age = 21.7 years). Most participants (79%) reported at least one cancer-related late effect, most commonly fatigue (40%) and memory/learning difficulties (34%). Brain tumor survivors reported a higher total number of late effects than survivors with other diagnoses (mean = 5.7 vs. 3.2, P  < .001). Participants' most commonly reported motivators for engaging in care were to understand problems that may occur later in life because of their cancer and/or treatment (98.5%) and to get reassurance about one's health (97.4%). The proportion of survivors endorsing each motivating factor was similar across cancer diagnoses, with the exception of learning more about insurance and pensions (highest in brain tumor survivors = 80%). In multivariable analyses, survivors were more likely to report being engaged in survivorship care if they were younger (P  < .001), less time had elapsed since their diagnosis (P  < .001), or they reported a higher number of motivating factors (P  = .016). Conclusion Survivors report a range of health problems decades after treatment completion. Understanding the burden of late effects, and motivators for seeking survivorship care to manage these health problems, is important for ensuring that tailored interventions or services are available to meet the needs of this growing population and to design effective models of survivorship care. [ABSTRACT FROM AUTHOR]

Background: Most studies assessing pathophysiological heterogeneity in asthma have been conducted in high-income countries (HICs), with little known about the prevalence and characteristics of different asthma inflammatory phenotypes in low-and middle-income countries (LMICs). This study assessed sputum inflammatory phenotypes in five centres, in Brazil, Ecuador, Uganda, New Zealand (NZ) and the United Kingdom (UK).Methods: We conducted a cross-sectional study of 998 asthmatics and 356 non-asthmatics in 2016-20. All centres studied children and adolescents (age range 8-20 years), except the UK centre which involved 26-27 year-olds. Information was collected using questionnaires, clinical characterization, blood and induced sputum.Results: Of 623 asthmatics with sputum results, 39% (243) were classified as eosinophilic or mixed granulocytic, i.e. eosinophilic asthma (EA). Adjusted for age and sex, with NZ as baseline, the UK showed similar odds of EA (odds ratio 1.04, 95% confidence interval 0.37-2.94) with lower odds in the LMICs: Brazil (0.73, 0.42-1.27), Ecuador (0.40, 0.24-0.66) and Uganda (0.62, 0.37-1.04). Despite the low prevalence of neutrophilic asthma in most centres, sputum neutrophilia was increased in asthmatics and non-asthmatics in Uganda.Conclusions: This is the first time that sputum induction has been used to compare asthma inflammatory phenotypes in HICs and LMICs. Most cases were non-eosinophilic, including in settings where corticosteroid use was low. A lower prevalence of EA was observed in the LMICs than in the HICs. This has major implications for asthma prevention and management, and suggests that novel prevention strategies and therapies specifically targeting non-eosinophilic asthma are required globally. [ABSTRACT FROM AUTHOR]

Genome sequences can reveal the extent of inbreeding in small populations. Here, we present the first genomic characterization of type D killer whales, a distinctive eco/morphotype with a circumpolar, subantarctic distribution. Effective population size is the lowest estimated from any killer whale genome and indicates a severe population bottleneck. Consequently, type D genomes show among the highest level of inbreeding reported for any mammalian species (F ROH ≥ 0.65). Detected recombination cross-over events of different haplotypes are up to an order of magnitude rarer than in other killer whale genomes studied to date. Comparison of genomic data from a museum specimen of a type D killer whale that stranded in New Zealand in 1955, with 3 modern genomes from the Cape Horn area, reveals high covariance and identity-by-state of alleles, suggesting these genomic characteristics and demographic history are shared among geographically dispersed social groups within this morphotype. Limitations to the insights gained in this study stem from the nonindependence of the 3 closely related modern genomes, the recent coalescence time of most variation within the genomes, and the nonequilibrium population history which violates the assumptions of many model-based methods. Long-range linkage disequilibrium and extensive runs of homozygosity found in type D genomes provide the potential basis for both the distinctive morphology, and the coupling of genetic barriers to gene flow with other killer whale populations. [ABSTRACT FROM AUTHOR]

Background and Aims Polyploidy is an important process that often generates genomic diversity within lineages, but it can also cause changes that result in loss of genomic material. Island lineages, while often polyploid, typically show chromosomal stasis but have not been investigated in detail regarding smaller-scale gene loss. Our aim was to investigate post-polyploidization genome dynamics in a chromosomally stable lineage of Malvaceae endemic to New Zealand. Methods We determined chromosome numbers and used fluorescence in situ hybridization to localize 18S and 5S rDNA. Gene sequencing of 18S rDNA, the internal transcribed spacers (ITS) with intervening 5.8S rDNA, and a low-copy nuclear gene, GBSSI-1 , was undertaken to determine if gene loss occurred in the New Zealand lineage following polyploidy. Key Results The chromosome number for all species investigated was 2 n  = 42, with the first published report for the monotypic Australian genus Asterotrichion. The five species investigated all had two 5S rDNA signals localized interstitially on the long arm of one of the largest chromosome pairs. All species, except Plagianthus regius , had two 18S rDNA signals localized proximally on the short arm of one of the smallest chromosome pairs. Plagianthus regius had two additional 18S rDNA signals on a separate chromosome, giving a total of four. Sequencing of nuclear ribosomal 18S rDNA and the ITS cistron indicated loss of historical ribosomal repeats. Phylogenetic analysis of a low-copy nuclear gene, GBSSI-1 , indicated that some lineages maintained three copies of the locus, while others have lost one or two copies. Conclusions Although island endemic lineages show chromosomal stasis, with no additional changes in chromosome number, they may undergo smaller-scale processes of gene loss and concerted evolution ultimately leading to further genome restructuring and downsizing. [ABSTRACT FROM AUTHOR]

Background Many public health experts have claimed that elimination strategies of pandemic response allow 'normal social life' to resume. Recognizing that social connections and feelings of normality are important for public health, this study examines whether, and for whom, that goal is realized, and identifies obstacles that may inhibit its achievement. Methods Thematic analysis of narratives obtained via a qualitative cross-sectional survey of a community cohort in Aotearoa | New Zealand. Results A majority of participants reported that life after elimination was 'more or less the same' as before the pandemic. Some became more social. Nevertheless, a sizeable minority reported being less social, even many months after elimination. Key obstacles to social recovery included fears that the virus was circulating undetected and the enduring impact of lockdowns upon social relationships, personal habits and mental health. Within our sample, old age and underlying health conditions were both associated with a propensity to become less social. Conclusions Elimination strategies can successfully allow 'normal social life' to resume. However, this outcome is not guaranteed. People may encounter difficulties with re-establishing social connections in Zero-COVID settings. Measures designed to overcome such obstacles should be an integral part of elimination strategies. [ABSTRACT FROM AUTHOR]

Background: Past research has established that transgender people experience significant disparities in mental health outcomes and healthcare dissatisfaction compared with cisgender people, but more research is needed on how supportive healthcare interactions relate to the mental health of transgender people.Objectives: The 2 main aims of our analyses were: (i) to establish the most common negative experiences in healthcare and the most common supportive experiences specifically with primary care doctors for transgender people; and (ii) to examine the association of supportive experiences with mental health variables after controlling for demographic factors.Methods: Data from the 2018 Counting Ourselves nationwide survey of transgender people were analysed using regression modelling. The 948 participants with a primary care doctor or general practitioner were included in analyses. Participants were aged 14-83 years old (mean 30.20).Results: The most common supportive experiences involved primary care doctors treating transgender people equitably, with competence, and with respect. Participants with more negative healthcare experiences had higher psychological distress as well as higher likelihood of reporting nonsuicidal self-injury and suicidality. Conversely, participants with more experiences of supportive primary care doctors had lower psychological distress and were less likely to have attempted suicide in the past 12 months.Conclusion: When transgender people receive supportive care from their primary care providers they experience better mental health, despite ongoing negative healthcare experiences. Future research is needed to confirm ways of supporting positive trajectories of mental health for transgender people but these findings demonstrate the importance of positive aspects of care. [ABSTRACT FROM AUTHOR]

Crop multi-model ensembles (MME) have proven to be effective in increasing the accuracy of simulations in modelling experiments. However, the ability of MME to capture crop responses to changes in sowing dates and densities has not yet been investigated. These management interventions are some of the main levers for adapting cropping systems to climate change. Here, we explore the performance of a MME of 29 wheat crop models to predict the effect of changing sowing dates and rates on yield and yield components, on two sites located in a high-yielding environment in New Zealand. The experiment was conducted for 6 years and provided 50 combinations of sowing date, sowing density and growing season. We show that the MME simulates seasonal growth of wheat well under standard sowing conditions, but fails under early sowing and high sowing rates. The comparison between observed and simulated in-season fraction of intercepted photosynthetically active radiation (FIPAR) for early sown wheat shows that the MME does not capture the decrease of crop above ground biomass during winter months due to senescence. Models need to better account for tiller competition for light, nutrients, and water during vegetative growth, and early tiller senescence and tiller mortality, which are exacerbated by early sowing, high sowing densities, and warmer winter temperatures. [ABSTRACT FROM AUTHOR]

Open in new tab Download slide Open in new tab Download slide OBJECTIVES For the technical management of tracheal anastomosis, developing new and simple methods is required to relieve anastomotic tension. This study aimed to investigate whether basic fibroblast growth factor (bFGF) only once injected immediately before anastomosis promotes cartilage regeneration at the tracheal anastomosis and whether the regenerated cartilage has the effect of reinforcing the anastomosis in a rabbit model. METHODS New Zealand white rabbits were anaesthetized, and the cervical trachea was exposed through a cervical midline incision, followed by resection of the 10th tracheal cartilage. The rabbits were categorized into 2 groups: the bFGF group (n  = 6) and the control group (n  = 6). In the former group, bFGF (25 μg) was administered into the submucosal layer of the cartilage using a 27-G needle immediately before tracheal anastomosis. The animals were sacrificed 4 weeks later. Histological, mechanical and biochemical evaluations were performed on this anastomosed trachea. RESULTS At 4 weeks of age, the anastomoses were spindle-shaped and displayed maximum diameter at the injection site compared with those in the control group. Histological evaluation showed that cartilage tissue had regenerated between the 9th and 11th tracheal cartilage rings. Tensile test showed that the anastomoses displayed a significantly high strain/stress ratio (P   =  0.035). The collagen type II and glycosaminoglycan levels were significantly increased, and the collagen type I level was significantly decreased (P  = 0.019, P  = 0.013 and P  = 0.045, respectively). CONCLUSIONS A new wound-healing concept of airway anastomosis could be provided by the results that single injection of bFGF regenerated tracheal cartilage in rabbits and strengthened the anastomosis by bridging the regenerated and well-matured cartilage. Further investigation of this method will lead to potential clinical applications for reinforcement of tracheal anastomoses. [ABSTRACT FROM AUTHOR]

Background Periprosthetic joint infection (PJI) is a devastating condition and there is a lack of evidence to guide its management. We hypothesized that treatment success is independently associated with modifiable variables in surgical and antibiotic management. Methods The is a prospective, observational study at 27 hospitals across Australia and New Zealand. Newly diagnosed large joint PJIs were eligible. Data were collected at baseline and at 3, 12, and 24 months. The main outcome measures at 24 months were clinical cure (defined as all of the following: alive, absence of clinical or microbiological evidence of infection, and not requiring ongoing antibiotic therapy) and treatment success (clinical cure plus index prosthesis still in place). Results Twenty-four-month outcome data were available for 653 patients. Overall, 449 patients (69%) experienced clinical cure and 350 (54%) had treatment success. The most common treatment strategy was debridement and implant retention (DAIR), with success rates highest in early postimplant infections (119 of 160, 74%) and lower in late acute (132 of 267, 49%) and chronic (63 of 142, 44%) infections. Selected comorbidities, knee joint, and Staphylococcus aureus infections were independently associated with treatment failure, but antibiotic choice and duration (including rifampicin use) and extent of debridement were not. Conclusions Treatment success in PJI is associated with (1) selecting the appropriate treatment strategy and (2) nonmodifiable patient and infection factors. Interdisciplinary decision making that matches an individual patient to an appropriate management strategy is a critical step for PJI management. Randomized controlled trials are needed to determine the role of rifampicin in patients managed with DAIR and the optimal surgical strategy for late-acute PJI. [ABSTRACT FROM AUTHOR]

Seismic and geodetic examinations of the Hikurangi subduction zone (HSZ) indicate a remarkably diverse and complex system. Here, we investigate the 3-D P -wave velocity structure of the HSZ by applying an iterative, nested regional-global tomographic algorithm. The new model reveals enhanced details of seismic variations along the HSZ. We also relocate over 57 000 earthquakes using this newly developed 3-D model and then further improve the relative locations for 75 per cent of the seismicity using waveform cross-correlation. Double seismic zone characteristics, including occurrence, depth distribution and thickness change along the strike of the HSZ. An aseismic but fast Vp zone separates the upper and lower planes of seismicity in the southern and northern North Island. The upper plane of seismicity correlates with low Vp zones below the slab interface, indicating fluid-rich channels formed on top and/or within a dehydrated crust. A broad low Vp zone is resolved in the lower part of the subducting slab that could indicate hydrous mineral breakdown in the slab mantle. In the northern North Island and southern North Island, the lower plane of seismicity mostly correlates with the top of these low Vp zones. The comparison between the thermal model and the lower plane of seismicity in the northern North Island supports dehydration in the lower part of the slab. The mantle wedge of the Taupo volcanic zone (TVZ) is characterized by a low velocity zone underlying the volcanic front (fluid-driven partial melting), a fast velocity anomaly in the forearc mantle (a stagnant cold nose) and an underlying low velocity zone within the slab (fluids from dehydration). These arc-related anomalies are the strongest beneath the central TVZ with known extensive volcanism. The shallow seismicity (<40 km depth) correlates with geological terranes in the overlying plate. The aseismic impermeable terranes, such as the Rakaia terrane, may affect the fluid transport at the plate interface and seismicity in the overlying plate, which is consistent with previous studies. The deep slow slip events (25–60 km depths) mapped in the Kaimanawa, Manawatu and Kapiti regions coincide with low Vp anomalies. These new insights on the structure along the HSZ highlight the change in the locus of seismicity and dehydration at depth that is governed by significant variations in spatial and probably temporal attributes of subduction zone processes. [ABSTRACT FROM AUTHOR]

Seedlings of New Zealand's treeline-forming Fuscospora cliffortioides (Hook.f.) perform poorly beyond the established canopy, limiting treeline advance. To test the long-standing assumption that photoinhibition impairs regeneration in the subalpine belt of New Zealand's Southern Alps, we assessed photosystem II (PSII) performance of seedling-sized individuals and microclimate variation. We performed diurnal, non-invasive chlorophyll- a -fluorescence measurements on exposed and canopy-sheltered individuals at two sites in New Zealand's Southern Alps during summer and winter. Diurnal recordings of the effective (ΦPSII) and optimal (F v/ F m) photosynthetic quantum yield were supplemented with light response curves and micro-temperature recordings. ΦPSII returned to near-optimal values around 0.8 after 30 min of shading, which rules out accumulative or long-term photoinhibition effects. The maximum electron transport rate derived from rapid light curves was significantly higher (+12%) in exposed compared with canopy-shaded individuals. Summer temperature fluctuated widely on the scree (−0.5 to 60.5 °C) and near seedlings (−2 to 26.5 °C). Our results revealed a remarkable level of light adaptation and contradict previous studies hinting at high light-induced photoinhibition as a treeline-limiting factor in the Southern Alps. By linking low ΦPSII on winter mornings, and large, sudden temperature drops in summer, we suspect that cold-induced photoinhibition might occur but the rapid recovery of ΦPSII seen across a wide temperature range makes lethal photo-oxidative damage rather unlikely. Given the demonstrably low summer frost tolerance of F. cliffortioides , cold-related damage resulting from frost events during the growing season or embolism induced by frost drought may offer more plausible explanations for the poor seedling establishment. Duration and frequency of these events could diminish with global warming, which may promote treeline advance. [ABSTRACT FROM AUTHOR]

The 2016 M w 7.8 Kaikoura, New Zealand, earthquake occurred along the eastern margin of the transition region between active subduction in the North Island and oblique collision in the South Island. To infer crustal properties, we imaged Q (1/seismic attenuation) by combining selected M > 3.5 aftershocks with data from previous Q models. For 158 distributed aftershocks, we fit spectral decay on temporary stations and all Geonet stations, providing 6194 t * p and 19 497 t * s. Considering the varied rheology and faults, we also used 2.5-D numerical models to study ductile strain development. The complex earthquake ruptured an ∼180-km-long zone of multiple faults, which involved jumping around the complicated eastern end of the Hope fault, without significant slip on the Hope fault. The Qs and Qp results show features in the upper and lower crust which correlate to the distribution and types of fault rupture. This earthquake involved numerous faults over a region of greywacke crust, where the underlying high Q Cretaceous slab is about 30-km depth. It initiated with ∼5-m slip on the Humps fault in a region of background seismicity and low Q lower crust, adjacent to the Hope fault. The central region near Kaikoura shows a high Q crustal block, which appears to have inhibited rupture; as the rupture progressed over several small faults to jump offshore of the apparently strong block. Underlying the Kaikoura greywacke crust, below 20-km depth, there is a 40-km-long region of increased Vp, Qs and gravity, which likely represents an intraplate plutonic complex emplaced into the Hikurangi Plateau, forming an elevated section which influences deformation. In the northern section, in a region with relatively uniform moderate to low Q , the earthquake evolved into the relatively continuous ∼80-km-long major rupture along the Jordan, Kekerengu and Needles faults, with ∼6–20 m dextral slip at depth and surface displacements of ∼10 m dextral and ∼2 m vertical. The northern progression of the rupture stopped when it approached an abrupt change to high Q crust across Cook Strait. At 20–30-km depth northwest of the rupture, deeper zones with low Q are consistent with regions of distributed ductile shear and creep where the observed afterslip may have occurred, where the underlying slab is 25–40 km deep. The numerical model shows that ductile deformation localizes in this area of lower crust above the relatively strong slab, connecting outer faults (Kekerengu) to inland faults (Clarence, Awatere, Wairau), and demonstrates that no subduction thrust is required under the Marlborough region. [ABSTRACT FROM AUTHOR]

Aims The limited existing research on drinking games and predrinking among university students in Argentina, Australia, Canada, and New Zealand suggests that participation in these risky drinking practices is relatively widespread among this population. Drinking norms and alcohol use can vary across countries and in different regions of the globe. The measurement of drinking games and predrinking participation between studies also differs, making cross-country comparisons difficult. The present study explored differences in past month participation in drinking games and predrinking among university students from a large public university in Argentina, Australia, Canada, and New Zealand. Methods The data analytic sample consisted of 1134 university students (ages 18–25, M age = 20.2 years; 72.6% women) from Argentina (n  = 349), Australia (n  = 280), Canada (n  = 262), and New Zealand (n  = 243) who reported weekly alcohol consumption. Students completed a confidential survey on drinking attitudes and behaviors. Results Controlling for age, gender, and weekly drink consumption, there were no cross-country differences in past month participation in predrinking. In contrast, university students from Canada and New Zealand were more likely to have played a drinking game in the past month than students from Australia and Argentina. Conclusions The present finding suggest that university students from Argentina, Australia, Canada, and New Zealand are equally likely to participate in predrinking regardless of country; however, the likelihood of playing drinking games differs as a function of country site. [ABSTRACT FROM AUTHOR]