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The synthesis of a novel disorazole C1 analogue is described, and its biological activity as a cytotoxic compound is reported. Based on our convergent and flexible route to the disorazole core, we wish to report a robust strategy to synthesize a non-symmetrical disorazole in which we couple one half of the molecule containing the naturally occurring oxazole heterocycle and the second half of the disorazole macrocycle containing a thiazole heterocycle. This resulted in a very unusual non-symmetrical disorazole C1 analogue containing two different heterocycles, and its biological activity was studied. This provided exciting information about SAR (structure-activity-relationship) for this highly potent class of antitumor compounds. [ABSTRACT FROM AUTHOR]

At present, there is limited theoretical clarity on the nature of Islamic spiritual care, which is a developing discipline around the world. How it is defined will be instrumental for spiritual care institutions, professionals and recipients of spiritual care in the years to come. This article wishes to understand and explore the idea and vision behind Islamic spiritual care and why this line of investigation may be of importance to care providers with different faith backgrounds. [ABSTRACT FROM AUTHOR]

Asceticism or renunciation (zuhd) is generally viewed as turning away from the world and all it has to offer in order to connect to the divine. The well-known mystical theorist, Muḥyī al-Dīn ibn 'Arabī (d. 638/1240), adds a denotation of asceticism to this conventional definition. Ibn 'Arabī argues that the impetus for the creation of the cosmos was the divine wish to be known by something other than Itself. As the fulfilment of this wish, the universe is nothing but a manifestation of the cataphatic aspect of God described as His 'most beautiful Names' (al-Asmā' al-ḥusnā) in the Qur'an, which is not God as He truly is in His apophatic essence that can never be comprehended, much less manifested. This means that there are two forms of asceticism or connecting to the divine: one is to assert God's transcendence and His true apophatic nature by renouncing the world, while the other is to emphasise His comparability by embracing the world as a manifestation of God's most beautiful Names. Ibn 'Arabī presents the world-renouncing form of asceticism through the chapter of Prophet Idrīs in his most popular work, Fuṣūṣ al-ḥikam, and he presents the world-embracing from of asceticism through the chapter of Prophet Ilyās. He then combines both forms of asceticism in the chapter of Prophet Muḥammad. [ABSTRACT FROM AUTHOR]

The 'religion/secular' frame should be retired as a way of characterizing contemporary northern European cultures. The concepts of 'secularity' and 'religion' are both falsifying and question begging. They invisibly and unhelpfully predetermine the conversation about who and where we are now. Further, they are terms which increasingly lack salience in these cultures. If we seek to locate and articulate, in order to reflectively engage, the horizons within which contemporary northern Europeans generally live, the goods that orient people's lives, the ideas and values that move and motivate them, we need to talk not about 'religion' and the lack of it, but about the idea of the human. Within the concept of the human is nested today the sense of orientation, meaning, goodness and importance that notions of 'religion' used to express. This is the conceptual territory on which arguments about 'what really matters' are now conducted. If one wishes to have salience in contemporary culture, one needs to speak to this. [ABSTRACT FROM AUTHOR]

This paper explores the religious function and meaning of long banner paintings from Cave 17 of the Mogao Caves in Dunhuang, in conjunction with material culture in Northwestern China in the ninth and tenth centuries CE. The so-called forty-nine-chi banners have peculiar traits such as extremely long lengths, an optional triangular headpiece, and a paired or single strip of textile on which a series of standing bodhisattvas are painted. The author focuses on the large number of textiles used for such banners and questions how the extraordinary length and material used contributed to fulfilling the donor's wishes. By examining both the banners' physical characteristics, such as the type of textiles, pigments, and configurations, and the theological background based on the Buddhist and Daoist scriptures about longevity, repentance, and healing, the author suggests that the long banners are a materialized form of longevity and prosperity by physically lengthening the banner with multiple bolts of silk. This paper further argues that depicting multiple bodhisattvas in a pictorial form on a long strip of textile was regarded equally as a powerful means for obtaining good health, prolonging life, eliminating sins, and thus being reborn in the Pure Land. [ABSTRACT FROM AUTHOR]

Blockchain is a developing technology that can provide users with such advantages as decentralization, data security, and transparency of transactions. Blockchain has many applications, one of them is the decentralized finance (DeFi) industry. DeFi is a huge aggregator of various financial blockchain protocols. At the moment, the total value locked in these protocols reaches USD 82 billion. Every day more and more new users come to DeFi with their investments. The concept of decentralized finance involves the creation of a single ecosystem of many blockchains that interact with each other. The problem of combining and interacting blockchains becomes crucial to enable DeFi. In this paper, we look at the essence of the DeFi industry, the possibilities of overcoming the problem of cross-blockchain interaction, present our approach to solving this problem with the Wish Swap platform, which, in particular, provides improved fault-tolerance for cross-chain interaction by using multiple backend nodes and multisignatures. We analyze the results of the proposed solution and demonstrate how a prototype pre-sale application can be created based on the proposed concept. [ABSTRACT FROM AUTHOR]

Falling birth rates and rising life expectancy are leading to global aging. The proportional increase in older people can be observed in almost all countries and regions worldwide. As a result, more people spend their later years in nursing homes. In homes where person-centered care is implemented, residents report greater satisfaction and quality of life. This approach is based on the wishes and needs of the residents. Therefore, the purpose of this scoping review is to explore the wishes and needs of nursing home residents. A scoping review of the literature was conducted in which 12 databases were systematically searched for relevant articles according to PRISMA-ScR guidelines. Both quantitative and qualitative study designs were considered. A total of 51 articles met the inclusion criteria. Included articles were subjected to thematic analysis and synthesis to categorize findings into themes. The analysis identified 12 themes to which the wishes and needs were assigned: (1) Activities, leisure, and daily routine; (2) Autonomy, independence, choice, and control; (3) Death, dying, and end-of-life; (4) Economics; (5) Environment, structural conditions, meals, and food; (6) Health condition; (7) Medication, care, treatment, and hygiene; (8) Peer relationship, company, and social contact; (9) Privacy; (10) Psychological and emotional aspects, security, and safety; (11) Religion, spirituality; and (12) Sexuality. Nursing home residents are not a homogeneous group. Accordingly, a wide range of needs and wishes are reported in the literature, assigned to various topics. This underscores the need for tailored and person-centered approaches to ensure long-term well-being and quality of life in the nursing home care setting. [ABSTRACT FROM AUTHOR]

Influencer marketing acquires customers who follow their favorite celebrities, who have shared beliefs and opinions. This research explores the self-motives and influencer-related factors that lead to influencer congruence. Influenced customers subsequently recommend those influencers to others. No concrete scale of recommendation is available so far. This research also conceptualizes, develops, and validates a scale for recommendations. In this study, 451 respondents answered questions about the influencers they follow. Normality, reliability, and validity were used for hypothesis testing. Results show the positive and direct impacts of all proposed hypotheses. The findings contribute to the literature by presenting a balanced approach to studying two parallel yet integral aspects of influencer marketing: the influencer and the consumer. [ABSTRACT FROM AUTHOR]

This paper discusses the new linguistic treatment which is formulated for the first time in Neoplatonism, when Ammonius of Hermeias tries to compromise the linguistic views of Plato and Aristotle in his commentary on Aristotle's On Interpretation. Ammonius integrates doctrines of Plato, Aristotle and Proclus, who was his teacher in Athens. According to Ammonius, Aristotle does not contradict Plato, who believes in the 'divine name-giver', the one that attributed the original names to beings; on the contrary, Aristotle confirms what Socrates says in the Cratylus, where he reproaches both his interlocutors for their extreme views. Ammonius examines several aspects of language, capturing Aristotle's non-adherence to such an extremity. As he wishes to exempt Aristotle from Proclus' censure, his position does not rest on assumptions, but he goes so far as to investigate Aristotle's own linguistic behavior. Ammonius manifestly opts for reasoning the reconciliation between Plato and Aristotle, but he is thus led to put the concept of a 'specialist name-giver' in Aristotle's mouth, without clarifying that he is talking about mankind, excluding the divine, although Aristotle never talks about a 'specialist', but just about the need to create names, based on the agreement between the members of a linguistic community. [ABSTRACT FROM AUTHOR]