11 results on '"Solovova, Olga"'
Search Results
2. Mobile Assisted Language Learning of Less Commonly Taught Languages: Learning in an Incidental and Situated Way through an App
- Author
-
Cervini, Cristiana, Solovova, Olga, Jakkula, Annukka, and Ruta, Karolina
- Abstract
Learning has been moving out of classrooms into virtual and physical spaces for over a decade now (Naismith, Lonsdale, Vavoula, & Sharples, 2004). It is becoming mobile "in space", i.e. carried across various domains (workplace, home, places of leisure), "in time", as it encompasses different moments of the day, and in terms of "learning purpose", which may be related to work, self-improvement or leisure (Vavoula & Sharples, 2002). In line with the principles of learning in an informal, incidental and mobile way, an open source and geolocalised application for learning foreign languages with a smartphone is being implemented within Key Action 2 of the Erasmus Plus European framework by the project called ILOCALAPP--Incidentally Learning Other Cultures and Languages--(Ceccherelli et al., 2016). ILOCALAPP will result in an app to aid in learning Finnish, Italian, Polish and Portuguese embedded within their respective cultural practices. The target group is mobility students, so the app will be situated in the university city where international students arrive, i.e. the Finnish language content will unfold in Rovaniemi, Italian in Bologna, Polish in Poznan, and Portuguese in Coimbra. The learning content will blend in the students' everyday contexts, whereby the app would be used incidentally in a game-like manner, thus providing enjoyable learning moments throughout their daily activities in an informal way. [For the complete volume of short papers, see ED572005.]
- Published
- 2016
3. Atypical structure of the nuclear membrane, distribution of nuclear pores and lamin B1 in spermatozoa of patients with complete and partial globozoospermia.
- Author
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Bragina, Elizaveta, Kurchashova, Svetlana, Suhomlinova, Marina, Gasanova, Tatiana, Ermolaeva, Svetlana, Sorokina, Tatyana, Kirs, Eva, Arifulin, Evgeniy, Solovova, Olga, Ryzhkova, Oxana, Khayat, Sabina, Andreeva, Marina, and Chernykh, Vyacheslav
- Subjects
NUCLEAR membranes ,SPERMATOZOA ,NUCLEAR structure ,MALE infertility ,TRANSMISSION electron microscopy ,PROGERIN - Abstract
Globozoospermia is a form of male infertility characterized by spermatozoa with spherical heads lacking acrosomes. The aim of this study was to evaluate ultrastructural and molecular defects in different types of globozoospermia. Semen samples from 12 infertile patients (9 with complete globozoospermia and 3 with partial globozoospermia) and 10 normozoospermic men (control) were examined by transmission electron microscopy and immunocytochemistry with antibodies against lamin B1. The presence of lamin A and progerin was assessed by reverse transcription-PCR. Whole exome sequencing was performed in three patients. In semen sampleswith complete and partial globozoospermia, lamin B1 was observed at the periphery of sperm nuclei, whereas lamin A and progerin were absent. Nuclear envelope pores were found in spermatozoa from both patient groups, regardless of morphology and chromatin condensation, in contrast to the control group. Non-condensed chromatin was present in 51%-81% of cases of complete globozoospermia and in 36%-79% of cases of partial globozoospermia. Homozygous DPY19L2 and SPATA16 variants were identified in two patients with partial globozoospermia and one patient with complete globozoospermia. An atypical nuclear membrane with abnormal nuclear pore distribution and lamin B1 localization was observed in spermatozoa from patients with both complete and partial globozoospermia. The genetic defects in the DPY19L2 and SPATA16 genes detected in patients from both globozoospermic groups suggest a generalized disruption of nuclear structure in globozoospermia, highlighting the genetic and phenotypic similarities between complete and partial globozoospermia. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Russian Regional Differences in Allele Frequencies of CFTR Gene Variants: Genetic Monitoring of Infertile Couples.
- Author
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Glotov, Andrey S., Chernykh, Vyacheslav B., Solovova, Olga A., Polyakov, Aleksander V., Donnikov, Maksim Yu., Kovalenko, Ludmila V., Barbitoff, Yury A., Nasykhova, Yulia A., Lazareva, Tatyana E., and Glotov, Oleg S.
- Subjects
GENETIC variation ,GENE frequency ,REGIONAL differences ,SEMEN analysis ,MALE infertility - Abstract
A male factor, commonly associated with poor semen quality, is revealed in about 50% of infertile couples. CFTR gene (Cystic Fibrosis Transmembrane Conduction Regulator) variants are one of the common genetic causes of azoospermia-related male infertility. Notably, the spectrum and frequency of pathogenic CFTR variants vary between populations and geographical regions. In this work, we made an attempt to evaluate the allele frequency (AF) of 12 common CFTR variants in infertile Russian men and healthy individuals from different districts of Russia. Because of the limited number of population-based studies on Russian individuals, we characterized the population AFs based on data from the Registry of Russian cystic fibrosis (CF) patients. In addition to the CF patient registry, we estimated the local frequencies of the same set of variants based on the results of genotyping of CF patients in local biocollections (from St. Petersburg and Yugra regions). AFs of common CFTR variants calculated based on registry and biocollection data showed good concordance with directly measured population AFs. The estimated region-specific frequencies of CFTR variants allowed us to uncover statistically significant regional differences in the frequencies of the F508del (c.1521_1523del; p.Phe508del) and CFTRdele2,3(21kb) (c.54-5940_273+10250del21kb; p.Ser18ArgfsX) variants. The data from population-based studies confirmed previous observations that F508del, CFTRdele2,3(21kb), and L138ins (c.413_415dup; p.Leu138dup)variants are the most abundant among infertile patients, and their frequencies are significantly lower in healthy individuals and should be taken into account during genetic monitoring of the reproductive health of Russian individuals. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Pathogenic Variants and Genotypes of the CFTR Gene in Russian Men with Cystic Fibrosis and CBAVD Syndrome.
- Author
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Chernykh, Vyacheslav, Krasovsky, Stanislav, Solovova, Olga, Adyan, Tagui, Stepanova, Anna, Marnat, Ekaterina, Shtaut, Maria, Sedova, Anna, Sorokina, Tatyana, Beskorovainaya, Tatyana, Kondratyeva, Elena, Shchagina, Olga, and Polyakov, Aleksandr
- Subjects
CYSTIC fibrosis transmembrane conductance regulator ,CYSTIC fibrosis ,RUSSIANS ,VAS deferens ,FREQUENCY spectra ,GENOTYPES - Abstract
Pathogenic CFTR variants cause cystic fibrosis (CF), and CF-related disorders (CF-RD), including bilateral aplasia of the vas deferens (CBAVD). The spectrum of clinical manifestations depends on the CFTR genotype. The frequency and spectrum of the CFTR variants vary between populations and clinical groups. CFTR variants and genotypes were analyzed in Russian men with CF (n = 546) and CBAVD syndrome (n = 125). Pathogenic variants were detected in 93.95% and 39.2% of the CF and CBAVD alleles, respectively. The most frequent c.1521_1523del (F508del; p.Phe508del) variant was found in 541 (49.5%) CF alleles. A total of 162 CFTR genotypes were revealed in CF patients, including 152 homozygous and 394 compound-heterozygous. The most common CF-genotype was F508del/F508del (24.9%). Other frequent CF-genotypes were F508del/3849+10kbC>T, F508del/CFTRdele2,3, and F508del/E92K. CF-causing variants and/or 5T allele were found in 88% of CBAVD patients: 5T/CFTRmut (48.0%), CFTRmut/N (17.6%), CFTRmut/CFTRmut (6.4%), 5T/5T (10.4%), 5T/N (5.6%) and N/N (12.0%), with the most common CBAVD-genotype being F508del/5T (29.6%). The allele frequencies of F508del, CFTRdele2,3 394delTT, and 3849+10kbC>T were significantly higher in CF patients. L138ins/L138ins, 2184insA/E92K, and L138ins/N genotypes were found in CBAVD, but not in CF patients. The results indicate certain differences in the frequency of some CFTR variants and genotypes in Russian CF and CBAVD patients. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. L138ins Variant of the CFTR Gene in Russian Infertile Men.
- Author
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Chernykh, Vyacheslav, Sorokina, Tatyana, Sedova, Anna, Shtaut, Maria, Solovova, Olga, Marnat, Ekaterina, Adyan, Tagui, Beskorovaynaya, Tatyana, Stepanova, Anna, Shchagina, Olga, and Polyakov, Aleksandr
- Subjects
MALE infertility ,CYSTIC fibrosis transmembrane conductance regulator ,AMPLIFIED fragment length polymorphism ,GENETIC variation ,VAS deferens - Abstract
(1) Introduction: Pathogenic variants in the CFTR (Cystic Fibrosis Transmembrane conductance Regulator, OMIM: 602421) gene cause Cystic Fibrosis (CF, OMIM: 219700) and CF-related disorders (CF-RD), often accompanied by obstructive azoospermia due to congenital bilateral aplasia of vas deferens (CBAVD, OMIM: 277180) in male patients. The L138ins (c.413_415dup; p. (Leu138dup)) is a mild variant in the CFTR gene that is relatively common among CF-patients in Slavic populations. The frequency of this variant in Russian infertile men has not been sufficiently studied; (2) Materials and Methods: The sample consisted of 6033 Russian infertile men. The patients were tested for 22 common in Russian populations pathogenic variants of the CFTR gene and the IVS9Tn-polymorphic locus of the intron 9. Molecular-genetic studies were performed using amplified fragment length polymorphism (AFLP-PCR), multiplex ligation-dependent probe amplification (MLPA), and nested PCR (for analysis of the IVS9Tn-polymorphic locus); (3) Results: Pathogenic variants in the CFTR were detected in 3.9% of patients. The most frequent variants were F508del and CFTRdele2.3(21kb), accounted for 61.0% and 7.1% of detected variants, respectively. The L138ins variant was detected in 17 (0.28%) individuals: one of them was homozygous, 10 patients were heterozygous, and 6 patients were compound-heterozygous (F508del/L138ins, n = 4; L138ins/N1303K, n = 1; L138ins/5T, n = 1). Two pathogenic CF-causing variants in the CFTR gene were detected in 8 patients, including 7 compound heterozygous (F508del/L138ins, n = 4; F508del/N1303K, n = 1; 2184insA/E92K, n = 1; 3849+10kbC>T/E92K, n = 1) and one homozygous (L138ins/L138ins). The L138ins variant was found in 7 out of 16 (43.75%) chromosomes in six of these patients. The most common pathogenic variant, F508del, was identified in five out of them, in 5 of 16 (31.25%) chromosomes. The allele frequency (AF) of the L138ins variant in the sample has been found to be 0.0014.; (4) Conclusions: The L138ins variant of the CFTR gene is the third most common variant after F508del and CFTRdele2.3(kb) among Russian infertile men. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. Genetics of Oocyte Maturation Defects and Early Embryo Development Arrest.
- Author
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Solovova, Olga Aleksandrovna and Chernykh, Vyacheslav Borisovich
- Subjects
- *
MITOCHONDRIAL DNA , *GENETICS , *FEMALE infertility , *INDUCED ovulation , *GAMETES , *OOGENESIS , *OVUM - Abstract
Various pathogenic factors can lead to oogenesis failure and seriously affect both female reproductive health and fertility. Genetic factors play an important role in folliculogenesis and oocyte maturation but still need to be clarified. Oocyte maturation is a well-organized complex process, regulated by a large number of genes. Pathogenic variants in these genes as well as aneuploidy, defects in mitochondrial genome, and other genetic and epigenetic factors can result in unexplained infertility, early pregnancy loss, and recurrent failures of IVF/ICSI programs due to poor ovarian response to stimulation, oocyte maturation arrest, poor gamete quality, fertilization failure, or early embryonic developmental arrest. In this paper, we review the main genes, as well as provide a description of the defects in the mitochondrial genome, associated with female infertility. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
8. Technologies, infrastructures and migrations: material citizenship politics.
- Author
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Amelung, Nina, Gianolla, Cristiano, Solovova, Olga, and Sousa Ribeiro, Joana
- Subjects
SCIENCE education ,TECHNOLOGY education ,EMIGRATION & immigration ,CITIZENSHIP education ,INFRASTRUCTURE (Economics) ,IMMIGRANTS' rights ,SUBJECTIVITY - Abstract
This article aims to explore the multiple uses and consequences of different technologies and infrastructures in the context of migrations and how such uses and consequences inhabit and transform migrants' rights and subjectivities. It reviews relevant literature at the intersection of citizenship, critical migration studies and science and technology studies (STS), focusing in particular on the current debates underway within critical citizenship studies that examine how technologies and infrastructures shape the ability to acts of citizenship. By mobilizing insights from STS, we focus on how these political subjectivities are shaped by certain sociomaterial and epistemic practices. By introducing the notion of material citizenship politics, the article outlines a way to differentiate three different constitutive forms between technologies, infrastructures and citizenship in migrations. Technologies and infrastructures can (1) constrain acts of citizenship in migration and border regimes; (2) constitute contestation and participation over citizenship; or (3) enable and shape alternative acts of citizenship in migration and border regimes. As it provides a theoretical background to the special issue, the article also serves as the introduction to the issue. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
9. Opening up ideological spaces for multilingual literacies at the margins of the Portuguese education system? Ethnographic insights from a Russian complementary school.
- Author
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Solovova, Olga
- Subjects
LITERACY ,SOCIOLINGUISTICS ,PORTUGUESE language ,SCHOOL children ,SCHOOLS ,GRANDPARENTS - Abstract
Eastern European migration to Portugal is a relatively recent yet significant phenomenon due to its impact on national legislation and discourses about language, citizenship and identity. Along with other migration movements to Portugal, it has also brought about changes in state policies. The monolingual order within the Portuguese education system has been reinforced through the adoption of the notion of 'Portuguese as a non-native language' and the creation of different categories of speakers of 'other' languages. While these discourses predominate within the national educational system, other discursive spaces (such as complementary schools and playgroups) are being constructed, on the margins of Portuguese society, where other languages and literacies are being learned and used, alongside Portuguese. This paper presents some insights from longitudinal ethnographic research (2004–2013) that was carried out in a complementary school for Russian-speaking children in Portugal run by their parents and grandparents. It looks into the complex ways in which literacy ideologies and practices were reproduced, contested and negotiated in this particular discursive space. It also shows how students drew on the language, literacy and semiotic resources within their communicative repertoires in different ways as they responded agentively to tasks set by the teacher. The paper concludes with reflections on the potential of the complementary school as a "safe space" for fostering flexible multilingual pedagogies. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
10. Mobile assisted language learning of less commonly taught languages: learning in an incidental and situated way through an app
- Author
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Annukka Jakkula, Olga Solovova, Cristiana Cervini, Karolina Ruta, Salomi Papadima-Sophocleous, Linda Bradley, Sylvie Thouësny., Cervini, Cristiana, Solovova, Olga, Jakkula, Annukka, Ruta, Karolina, and Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)
- Subjects
Mobile-assisted language learning ,Computer science ,Teaching method ,[SCCO.COMP]Cognitive science/Computer science ,Multilingualism ,02 engineering and technology ,Geolocalisation ,MALL, incidental learning, geolocalization, multilingualism ,computer.software_genre ,[SCCO]Cognitive science ,[SCCO.COMP] Cognitive science/Computer science ,Situated ,0202 electrical engineering, electronic engineering, information engineering ,Mathematics education ,Finno-Ugric languages ,Less commonly taught languages ,ComputingMilieux_MISCELLANEOUS ,Less Commonly Taught Languages ,Multimedia ,4. Education ,Educational technology ,MALL ,020206 networking & telecommunications ,020207 software engineering ,Incidental learning ,[SCCO] Cognitive science ,[SCCO.LING]Cognitive science/Linguistics ,[SCCO.LING] Cognitive science/Linguistics ,computer ,Mobile device - Abstract
Learning has been moving out of classrooms into virtual and physical spaces for over a decade now (Naismith, Lonsdale, Vavoula, & Sharples, 2004). It is becoming mobile ‘in space’, i.e. carried across various domains (workplace, home, places of leisure), ‘in time’, as it encompasses different moments of the day, and in terms of ‘learning purpose’, which may be related to work, self-improvement or leisure (Vavoula & Sharples, 2002). In line with the principles of learning in an informal, incidental and mobile way, an open source and geolocalised application for learning foreign languages with a smartphone is being implemented within Key Action 2 of the Erasmus Plus European framework by the project called ILOCALAPP - Incidentally Learning Other Cultures and Languages – (Ceccherelli et al., 2016). ILOCALAPP will result in an app to aid in learning Finnish, Italian, Polish and Portuguese embedded within their respective cultural practices. The target group is mobility students, so the app will be situated in the university city where international students arrive, i.e. the Finnish language content will unfold in Rovaniemi, Italian in Bologna, Polish in Poznań, and Portuguese in Coimbra. The learning content will blend in the students’ everyday contexts, whereby the app would be used incidentally in a game-like manner, thus providing enjoyable learning moments throughout their daily activities in an informal way.
- Published
- 2016
11. Russian Regional Differences in Allele Frequencies of CFTR Gene Variants: Genetic Monitoring of Infertile Couples.
- Author
-
Glotov AS, Chernykh VB, Solovova OA, Polyakov AV, Donnikov MY, Kovalenko LV, Barbitoff YA, Nasykhova YA, Lazareva TE, and Glotov OS
- Subjects
- Humans, Male, Cystic Fibrosis Transmembrane Conductance Regulator genetics, Gene Frequency, Semen Analysis, Female, Cystic Fibrosis genetics, Infertility, Male genetics
- Abstract
A male factor, commonly associated with poor semen quality, is revealed in about 50% of infertile couples. CFTR gene (Cystic Fibrosis Transmembrane Conduction Regulator) variants are one of the common genetic causes of azoospermia-related male infertility. Notably, the spectrum and frequency of pathogenic CFTR variants vary between populations and geographical regions. In this work, we made an attempt to evaluate the allele frequency (AF) of 12 common CFTR variants in infertile Russian men and healthy individuals from different districts of Russia. Because of the limited number of population-based studies on Russian individuals, we characterized the population AFs based on data from the Registry of Russian cystic fibrosis (CF) patients. In addition to the CF patient registry, we estimated the local frequencies of the same set of variants based on the results of genotyping of CF patients in local biocollections (from St. Petersburg and Yugra regions). AFs of common CFTR variants calculated based on registry and biocollection data showed good concordance with directly measured population AFs. The estimated region-specific frequencies of CFTR variants allowed us to uncover statistically significant regional differences in the frequencies of the F508del (c.1521_1523del; p.Phe508del) and CFTRdele2,3(21kb) (c.54-5940_273+10250del21kb; p.Ser18ArgfsX) variants. The data from population-based studies confirmed previous observations that F508del, CFTRdele2,3(21kb), and L138ins (c.413_415dup; p.Leu138dup)variants are the most abundant among infertile patients, and their frequencies are significantly lower in healthy individuals and should be taken into account during genetic monitoring of the reproductive health of Russian individuals.
- Published
- 2023
- Full Text
- View/download PDF
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