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Your search keyword '"Al-Sehemi, Abdullah G."' showing total 1,236 results
Start Over Author "Al-Sehemi, Abdullah G." Publication Year Range Last 10 years Language english
1,236 results on '"Al-Sehemi, Abdullah G."'

121. Novel photodynamic therapy using two-dimensional NiPS3 nanosheets that target hypoxic microenvironments for precise cancer treatment

Author

Wu Zongze, Liu Quan, Wageh Swelm, Sun Zhe, Al-Hartomy Omar A., Al-Sehemi Abdullah G., Yan Lesen, Chen Jiaojuan, Zhang Wenjian, Yang Jilin, Zhang Han, and Liu Liping

Subjects
mitochondria, photodynamic therapy, nips3, photosensitizer, ros, Physics, QC1-999
Abstract

Photodynamic therapy (PDT) is a highly promising modality against cancer, but its efficacy is severely limited by the low oxygen content in solid tumors. In this study, a smart photosensitive NiPS3 nanosheet was developed to solve the problem of low oxygen to allow PDT to be performed against tumors. The photosensitized ROS generation mechanism of NiPS3 is the photon-generated electron-hole pathway, which can generate O2 ·− and ·OH at the conduction band and valance band, respectively. More crucial is that ·OH generation doesn’t need O2, and the O2 ·− can also work in a low O2 environment, and depleting oxygen in tumor cells. Modified with triphenylphosphine (TPP) and based on density functional theory (DFT) calculations and experimental data, the NiPS3@TPP nano-system underwent targeted action toward mitochondria. In vitro experiments demonstrated that the reactive oxygen species (ROS) produced by NiPS3@TPP altered mitochondrial membrane permeability, which not only prolonged the PDT effect but also resulted in mitochondria apoptosis pathways inducing an apoptosis cascade. In vivo experiments demonstrated the targeting capability with low toxicity of the NiPS3@TPP nano-system. Tumor targeting at the tested dose indicated that it represented a promising biocompatible photosensitizer for in vivo biomedical applications.

Published
2022
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122. Solvent effect, dipole moment, and DFT studies of multi donor–acceptor type pyridine derivative

Author

Alarfaji Saleh S., Al-Sehemi Abdullah G., and Pannipara Mehboobali

Subjects
multi donor–acceptor organic compounds, effect of solvent, fluorescence, Chemistry, QD1-999
Abstract

A donor–acceptor substituted derivative 2,6-diamino-4-(3,4,5-trimethoxy-phenyl)-pyridine-3,5-dicarbonitrile (DTPP) has been synthesized and its photophysical properties have been studied. Effect of solvent on the photophysical features of DTPP has been undertaken by steady state absorption and emission techniques. Strong solvatochromic emission has been observed due to intramolecular charge transfer characteristics, upon changing the solvent polarity, revealing the highly polar character of the excited state. Dipole moment changes between the excited and ground state have been estimated by using the theory of solvatochromism from Lippert–Mataga and Reichardt’s correlations. The geometrical parameters for ground and excited states, conformational flexibility, and NLO behavior of the molecule have been theoretically investigated. The electronic distributions of DTPP in HOMO and LUMO were also investigated using density functional theory (DFT) methods at B3LYP/6-31 G** level. The correlation of experimental results with theoretical predictions obtained via DFT substantiates the presence of polarity dependent of the emission spectra.

Published
2022
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