1. Association of single nucleotide polymorphisms of APOBEC3G with susceptibility to HIV-1 infection and disease progression among men engaging in homosexual activity in northern China.
- Author
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Li, Qiuyan, Qiao, Yuandong, Zhang, Guangfa, He, Ning, Zhang, Xuelong, Jia, Xueyuan, Sun, Haiming, Wang, Chuntao, and Xu, Lidan
- Subjects
HIV infection genetics ,HIV infection risk factors ,SINGLE nucleotide polymorphisms ,HOMOSEXUALITY ,DISEASE progression ,DISEASES in men ,DISEASE susceptibility - Abstract
Men who have sex with men (MSM) are at high risk of HIV infection. The APOBEC3G (apolipoprotein B mRNA editing catalytic polypeptide 3G) protein is a component of innate antiviral immunity that inhibits HIV-1 replication. In the present study, a total of 483 HIV-1 seropositive men and 493 HIV-1 seronegative men were selected to investigate the association between single nucleotide polymorphisms (SNPs) of the APOBEC3G gene and susceptibility to HIV-1 infection and AIDS progression among MSM residing in northern China. Genotyping of four SNPs (rs5757465, rs3736685, rs8177832, and rs2899313) of the APOBEC3G was performed using the SNPscan™ Kit, while the rs2294367 polymorphism was genotyped using the SNaPshot multiplex system. Our results disclosed no association between the SNPs of APOBEC3G and susceptibility to HIV-1, or effects of these polymorphisms on the CD4 T cell count or clinical phase of disease. A meta-analysis of 1624 men with HIV-1 infection and 1523 controls suggested that the association between rs8177832 and susceptibility was not significant. However, we observed a trend towards association with HIV-1 infection for haplotype TTACA ( p = 0.082). The potential role of variants of APOBEC3G in HIV-1/AIDS warrants further investigation. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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