1. Frailty and Risk of Dementia in Mild Cognitive Impairment Subtypes.
- Author
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Ward, David D., Wallace, Lindsay M. K., and Rockwood, Kenneth
- Subjects
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MILD cognitive impairment , *COGNITION disorders , *DEMENTIA , *CONFIDENCE intervals , *DISEASE progression , *RESEARCH , *RESEARCH methodology , *DISEASE incidence , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies , *QUESTIONNAIRES , *RESEARCH funding - Abstract
Risk factors for developing dementia from mild cognitive impairment (MCI) probably differ between MCI subtypes. We investigated how frailty relates to dementia risk in amnestic MCI (a-MCI; n = 2,799) and non-amnestic MCI (na-MCI; n = 629) in the National Alzheimer's Coordinating Center database. Although higher frailty increased dementia risk for people with either a-MCI or na-MCI, the larger risk was in na-MCI (interaction hazard ratio = 1.35 [95% confidence interval = 1.15-1.59], p < 0.001). Even after the onset of clinically significant cognitive impairment, poor general health, quantified by a high degree of frailty, is a significant risk for dementia. ANN NEUROL 2021;89:1221-1225. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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