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The author reflects on adjuvant hormonal therapy for treating premenopausal women with breast cancer. Topics include the prevalence of breast cancer cases in the U.S. in 2014 according to the American Cancer Society, the challenge of treating this type of cancer with tamoxifen and the role of aromatase inhibitors. Also discussed is chemotherapy induced amenorrhea.

Big data represents a new opportunity to increase our understanding of cancer care as it is practiced globally and to improve it through the refinement of clinic guidelines and the identification of knowledge gaps. Here we review the historical approach to evidence development (randomized clinical trials), some of their limitations, and the complementary role that big data analytics may play. [ABSTRACT FROM AUTHOR]