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A new emerging disease of quinoa, quinoa basal stem rot (QBSR), has been recorded in Shanxi Province, China. Observed during the inflorescence emergence stage, the pathogen causes wilting, foliar chlorosis, leaf abscission and eventual death of quinoa. In this study, isolates were identified as Fusarium solani using morphology, molecular and phylogenetic analysis (using sequences of calmodulin, rDNA internal transcribed spacer region, RNA polymerase II B‐subunits RPB1 RPB1 and RPB2 RPB2, and translation elongation factor 1‐α), and pathogenicity analysis. Twenty‐seven isolates were classified into two different groups according to their morphological characteristics, and the mycelial growth rate of Group 2 was higher than that of Group 1 on six different media. The optimum growth temperature for both groups was 30°C and the highest mycelial growth rates were 9.2 and 10.0 mm/day, for Groups 1 and 2, respectively. The sporodochial conidia (SC) and aerial conidia (AC) germinated normally at 15–25°C and 10–40°C, respectively, and the width of SC and AC germ tubes were 1.4 and 2.2 μm. The lethal temperature for AC was 51°C for 20 min, and SC stopped germinating at 45°C. Pathogenicity tests of representative isolates showed that mycelia or conidia caused typical symptoms of QBSR on wounded basal stems of Chenopodium quinoa at 6 days postinoculation. The optimum temperature for the onset of QBSR was 30°C for both groups of isolates, and lesion lengths ranged from 5.4 to 5.9 cm. Knowledge of this pathogen will provide useful information for effective disease management to prevent its spread. [ABSTRACT FROM AUTHOR]

Choanephora rot of Chenopodium plants (CRC) was observed at the flowering stages in seven plantations of Shanxi Province, China. CRC had caused leaf, stem, and panicle neck rot of C. quinoa, panicle neck and stem rot of C. formosanum, and stem rot of C. album. Typical symptoms included water-soaked, rapid soft rotting, and abundant sporulation on the whole panicle necks, stems, and leaves. Based on morphological characteristics, phylogenetic analyses, and pathogenicity tests, the pathogens were identified as Choanephoraceae cucurbitarum. Sporangiola and sporangiospore of C. cucurbitarum germinated at 30 °C and were able to germinate by two h post-inoculation (hpi). The germination rates of sporangiola and sporangiospore significantly increased at 3 to 4 hpi, and the germination rates ranged from 91.53 to 97.67%. The temperature had a significant effect on the pathogenicity of C. cucurbitarum the optimum pathogenic temperatures for stems of C. quinoa, C. formosanum and C. album were 30 °C after one day post-inoculation. Choanephoraceae cucurbitarum could infect white and red quinoa panicle necks between 20 and 30 °C, and the average lesion lengths were 0.21 to 3.62 cm. Among the five tested fungicides (boscalid, dimethomorph, isopyrazam, propiconazole, and tebuconazole), isopyrazam showed higher sensitivity to sporangiola germination of C. cucurbitarum, with an EC50 value of 0.6550 μg/mL. Isopyrazam and tebuconazole strongly inhibited the sporangiospore germination of C. cucurbitarum, which showed EC50 values of 0.4406 and 0.3857 μg/mL. To our knowledge, the present study found for the first time that C. cucurbitarum is a pathogen causing panicle neck of C. formosanum and stem rot of C. formosanum and C. album, while CRC first appeared in the quinoa panicle necks, and gradually expanded to stems and leaves. [ABSTRACT FROM AUTHOR]

Quinoa panicle rot (QPR) is a novel disease that poses a significant threat to quinoa production in China. Typical symptoms on panicles include a film of pale pink, grey‐white, or dark brown mould on the grains during the grain‐filling stage. Furthermore, QPR causes quinoa grain discolouration, unfilling, and malformation. In total, 37 isolates were identified as belonging to three species: Trichothecium roseum (nine isolates), Alternaria alternata (12), and Fusarium citri (16) based on morphology, and phylogenetic and pathogenicity characterization. The present study shows for the first time that T. roseum, A. alternata, and F. citri are the pathogens responsible for QPR. An evaluation of the growth and germination rates revealed a significant difference among the three species, with T. roseum and F. citri isolates having higher fitness in warmer (25–30℃) and humid conditions (water activity ≥0.98). However, A. alternata preferred cooler (20–25℃) and more arid conditions, and germinated in a wide range of water activities (water activity of 0.90–1.00). Among the three species, T. roseum and F. citri are probably responsible for the pink and grey diseased grains in humid regions, and A. alternata for the black‐brown diseased grains in arid regions. Pathogenicity tests showed that all three species could infect the quinoa panicles. The results of this study provide a basis for the recognition and management of QPR. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the prevalence and clinical characteristics of myelinated retinal nerve fibre (MRNF) in a large teleophthalmology system. Methods: All records between January 2015 and December 2015 from Daheng Prust teleophthalmology system were reviewed by 2 ophthalmologists independently. MRNF was classified into continuous group and discontinuous group according to the relationship between MRNF patches and optic disc. The number, total area and location of MRNF patches were analysed. Concomitant ocular diseases were documented. Results: Out of 51469 subjects, MRNF was detected in 304 eyes of 263 subjects with a prevalence rate of 0.51 ± 7.1% per subject and 0.30 ± 5.4% per eye. Among 304 eyes with MRNF, 239 (78.6%) eyes were in continuous group and 65 (21.4%) eyes were in discontinuous group. Single MRNF patch was found in 249 (81.9%) eyes and multiple MRNF patches were found in 55 (18.1%) eyes. MRNF of small size was found in 150 (49.3%) eyes. The ratios of multiple MRNF patches and small-sized MRNF in the continuous group were significantly higher than those in the discontinuous group (P =.014 and P <.001). In continuous group, the MRNF patches were located most frequently in the superior region (68.6%) of the optic disc; In discontinuous group, the MRNF patches were located most frequently in the inferotemporal region (38.5%) of the retina. Epiretinal membrane (12 eyes, 3.9%) was the most common concomitant ocular disease. Conclusion: MRNF is uncommon in China. MRNF usually presents unilaterally and as a single small whitish patch that is connected with optic disc. [ABSTRACT FROM AUTHOR]

Under the combined impacts of the operation time, design concept, and construction technology, extensive damage has occurred in tunnels built in China during the early stages of rapid development. Therefore, relevant research on tunnel damage is of urgent importance. This study takes the Liupanshan Highway Tunnel on G312 in Guyuan City as a case study, and uses field investigations, radar scans, and other methods to investigate the occurrence of a series of defects in the tunnel, including lining splitting, water leakage, and tunnel bottom damage, to analyze the damage characteristics and occurrence mechanism in detail based on both external causes and internal causes. From the results, by combing relevant materials both in China and abroad with the engineering characteristics, a comprehensive management method for reinforcing and strengthening damaged tunnels with a reinforced concrete umbrella arch is proposed. At the same time, considering the degradation in the bearing capacity of the existing lining structure and utilization degree of the bearing capacity of newly increased reinforced concrete umbrella arch, this study performs a theoretical analysis of the calculation for the safety factor of the reinforced damaged tunnel. The calculation results show that the reinforced Liupanshan Tunnel is in a secure state, which can provide references for similar projects in the future. [ABSTRACT FROM AUTHOR]

Objectives: This study examined the associations between perceived crime-specific victimization risk, avoidance behavior, and their relationships with health of older adults. Method: A representative sample of 453 Chinese aged 60 and older from Kunming provided information on their socio-demographic characteristics, perceived crime victimization risk, avoidance behavior, physical and mental health. Results: Avoidance behavior was common among participants, with 61.4% avoiding unsafe areas and 42.2% avoiding social activities. Path analyses showed that perceived risk of vandalism was associated with avoiding participating in social activities, while perceived risk of attack was related to avoiding unsafe areas during the day. Meanwhile, avoiding social activities and perceived risk of vandalism were significant predictors of poor mental health, and avoiding unsafe areas was a salient predictor of poor physical health. Perceived risk of attack had an indirect effect on physical health through avoiding unsafe areas during the day. Conclusion: Study findings highlight the importance of addressing perceived victimization risk in encouraging social participation and mobility among older adults. [ABSTRACT FROM AUTHOR]

This article examines the prevalence of victimization among older Chinese living in urban China and its psychological and behavioral impacts. A representative sample of 453 older adults aged 60 or above was recruited from Kunming, the People’s Republic of China, using multistage sampling method. Participants were individually interviewed on their demographic characteristics, experience of common crime and domestic violence victimization, fear of common crime and domestic violence, mental health, and constrained behavior. Results showed that 254 participants (56.1%) reported one or more types of common crime and 21 (4.6%) reported experiencing domestic violence in the past. Seventeen participants (3.8%) reportedly experienced both common crime and domestic violence victimization. There was no gender difference in the overall incidence of victimization but in some subtypes. Regression analyses indicated that past experience of common crime victimization was significantly associated with greater fear of common crime (β = .136, p = .004), poorer mental health (β = .136, p = .003), and more constrained behavior (β = .108, p = .025). Fear of common crime predicted increased constrained behavior (β = .240, p < .001) independent of gender, age, education, household finances, living arrangement, and physical health. Domestic violence victimization was not significant in predicting poor mental health and constrained behavior but was significant in predicting fear of domestic violence (β = .266, p < .001), which was related to poorer mental health (β = .102, p = .039). The study suggests the importance of taking older people’s risk and experience of victimization into consideration in gerontological research, practice, and policymaking. [ABSTRACT FROM AUTHOR]

The areca (Areca catechu L.) nut kernel (ANK) is a good potential protein source for its high protein content of 9.89–14.62 g/100 g and a high yield of around 300,000 tons per year in China. However, utilization of the areca nut kernel is limited. To expand the usage of ANK in pharmaceutical or foods industries, areca nut kernel globulin was extracted and angiotensin-I converting enzyme (ACE) inhibition peptides were prepared and identified using gel chromatography, reversed phase HPLC separation, UPLC-ESI-MS/MS analysis and in silico screening. Finally, a novel ACE-inhibitory heptapeptide (Ala–Pro–Lys–Ile–Glu–Glu–Val) was identified and chemically synthesized. The combination pattern between APKIEEV and ACE, and the inhibition kinetics, antihypertensive effect and endothlein-1 inhibition activity of APKIEEV were studied. The results of the molecular docking demonstrated that APKIEEV could bind to four active sites (not the key active sites) of ACE via short hydrogen bonds and demonstrated high ACE-inhibitory activity (IC50: 550.41 μmol/L). Moreover, APKIEEV exhibited a significantly lowering effect on both the systolic blood pressure and diastolic blood pressure of spontaneously hypertensive rats, and had considerable suppression ability on intracellular endothelin-1. These results highlight the potential usage of APKIEEV as ingredients of antihypertensive drugs or functional foods. [ABSTRACT FROM AUTHOR]

• 90 operating highway tunnels with defects are analyzed. • Five characteristics of tunnel defects are studied. • A set of defect prevention and treatment process is proposed. • The preventive measures and treatment measures are listed and analyzed. The number and length of highways in China far exceed those in other countries. Therefore, to better understand the defects that have occurred in Chinese highways that are currently in service, we collected data on the defects in 90 such tunnels. Using these data, we conducted a systematic study on the causes of such defects. Based on the characteristics thus obtained, the defects could be divided into seven categories: structural deformation, structural damage, material deterioration, water leakage, frost damage, construction defects, and others (accessory facility defects). The results reveal that lining cracks and water leakage are the most common defects in the highway tunnels of China. These tunnel defects can be categorized based on their risk, correlations, visibility, regional characteristics, and progressive nature. Human activities are the primary cause of highway tunnel defects. The treatment measures for such tunnel defects in China can be categorized as additional, repair, and replacement measures; these measures are selected based on actual requirements of addressing the defects. Lastly, corresponding preventive measures and disposal procedures are established based on the abovementioned analyses. The results of this study are expected to serve as a reference and provide significant guidance for the prevention and treatment of road tunnel defects. [ABSTRACT FROM AUTHOR]