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Your search keyword '"Hansen, Henrik"' showing total 521 results
521 results on '"Hansen, Henrik"'

25. IFN-[alpha] with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia

Author

Huuhtanen, Jani, Ilander, Mette, Yadav, Bhagwan, Dufva, Olli M.J., Lahteenmaki, Hanna, Kasanen, Tiina, Klievink, Jay, Olsson-Stromberg, Ulla, Stentoft, Jesper, Richter, Johan, Koskenvesa, Perttu, Hoglund, Martin, Soderlund, Stina, Dreimane, Arta, Porkka, Kimmo, Gedde-Dahl, Tobias, Gjertsen, Bjorn T., Stenke, Leif, Myhr-Eriksson, Kristina, Markevarn, Berit, Lubking, Anna, Dimitrijevic, Andreja, Udby, Lene, Bjerrum, Ole Weis, Hjorth-Hansen, Henrik, and Mustjoki, Satu

Subjects
Immune system -- Health aspects, Interferon alpha -- Dosage and administration -- Physiological aspects, Dasatinib -- Dosage and administration -- Physiological aspects, Chronic myeloid leukemia -- Drug therapy -- Physiological aspects, Chemotherapy, Combination -- Methods -- Physiological aspects, Health care industry
Abstract

In chronic myeloid leukemia (CML), combination therapies with tyrosine kinase inhibitors (TKIs) aim to improve the achievement of deep molecular remission that would allow therapy discontinuation. IFN-[alpha] is one promising candidate, as it has long-lasting effects on both malignant and immune cells. In connection with a multicenter clinical trial combining dasatinib with IFN-[alpha] in 40 patients with chronic-phase CML (NordCML007, NCT01725204), we performed immune monitoring with single-cell RNA and T cell receptor (TCR) sequencing (n = 4, 12 samples), bulk TCR[beta] sequencing (n = 13, 26 samples), flow cytometry (n = 40, 106 samples), cytokine analyses (n = 17, 80 samples), and ex vivo functional studies (n = 39, 80 samples). Dasatinib drove the immune repertoire toward terminally differentiated NK and [CD8.sup.+] T cells with dampened functional capabilities. Patients with dasatinib-associated pleural effusions had increased numbers of [CD8.sup.+] recently activated effector memory T (Temra) cells. In vitro, dasatinib prevented CD3-induced cell death by blocking TCR signaling. The addition of IFN-[alpha] reversed the terminally differentiated phenotypes and increased the number of costimulatory intercellular interactions and the number of unique putative epitope-specific TCR clusters. In vitro IFN-[alpha] had costimulatory effects on TCR signaling. Our work supports the combination of IFN-[alpha] with TKI therapy, as IFN-[alpha] broadens the immune repertoire and restores immunological function., Introduction Currently, the ultimate therapeutic goal in patients with chronic-phase chronic myeloid leukemia (CP-CML) is to achieve deep molecular remission, which would allow the discontinuation of tyrosine kinase inhibitor (TKI) [...]

Published
2022
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26. Comparison of Durable-Polymer Zotarolimus-Eluting and Biodegradable-Polymer Biolimus-Eluting Coronary Stents in Patients With Coronary Artery Disease: 3-Year Clinical Outcomes in the Randomized SORT OUT VI Trial

Author

Raungaard, Bent, Thygesen, Kristian, Sørensen, Jacob Thorsted, Nørgaard, Bjarne Linde, Andersen, Søren Lindholt, Madsen, Morten, Jensen, Svend Eggert, Christiansen, Evald Høj, Bøtker, Hans Erik, Hansen, Henrik Steen, Jensen, Lisette Okkels, Christiansen, Evald H., Hansen, Henrik S., Ravkilde, Jan, Thuesen, Leif, Aarøe, Jens, Villadsen, Anton B., Terkelsen, Christian J., Krusell, Lars R., Maeng, Michael, Kristensen, Steen D., Veien, Karsten T., Hansen, Knud N., Junker, Anders, Andersen, Søren L., Jensen, Svend E., and Jensen, Lisette O.

Published
2017
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28. Everolimus-Eluting Versus Biolimus-Eluting Stents With Biodegradable Polymers in Unselected Patients Undergoing Percutaneous Coronary Intervention: A Randomized Noninferiority Trial With 1-Year Follow-Up (SORT OUT VIII Trial)

Author

Maeng, Michael, Bøtker, Hans Erik, Christiansen, Evald Høj, Raungaard, Bent, Jensen, Svend Eggert, Hansen, Henrik Steen, Jensen, Lisette Okkels, Bargsteen, Helle, Pedersen, Helle, Jørgensen, Lars P., Ottosen, Pia, Pedersen, Karin M., Thygesen, Kristian, Sørensen, Jacob Thorsted, Andersen, Henning Rud, Kahlert, Johnny, Terkelsen, Christian Juhl, Kristensen, Steen Dalby, Carstensen, Steen, Aarøe, Jens, Villadsen, Anton Boel, Lassen, Jens Flensted, Thim, Troels, Eftekhari, Ashkan, Veien, Karsten Tange, Hansen, Knud Nørregaard, and Junker, Anders

Published
2019
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29. Lead and Copper Removal from Mine Tailings Using Lycium chilense and Haplopappus foliosus.

Author

Lazo, Pamela, Lazo, Andrea, Hansen, Henrik K., Gutiérrez, Claudia, and Ortiz-Soto, Rodrigo

Subjects
METAL tailings, COPPER, TAILINGS dams, ENDEMIC species, HEAVY metals, NATIVE species
Abstract

In Chile, the budget for managing environmental liabilities such as abandoned tailings impoundments is limited. Using native and endemic plant species to remove heavy metals from tailings represents a low-cost alternative. Ex situ phytoremediation experiments were conducted over a period of seven months. The endemic species Lycium chilense and native species Haplopappus foliosus were used to remove copper and lead from mine tailings. The results indicate that both species can concentrate levels of Cu and Pb higher than the toxicity threshold in the roots and aerial parts, and present high removal efficiency for Cu higher than 50%. In both species, the concentrations of the target elements are higher in the roots than in the aerial parts. Haplopappus foliosus presents the best performance, accumulating higher concentrations of Cu and Pb than Lycium chilense, and presenting a bioconcentration of over one for Cu. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Dietary intervention reverses molecular markers of hepatocellular senescence in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH.

Author

Flensted-Jensen, Mathias, Oró, Denise, Rørbeck, Emma A., Zhang, Chen, Madsen, Martin Rønn, Madsen, Andreas Nygaard, Norlin, Jenny, Feigh, Michael, Larsen, Steen, and Hansen, Henrik H.

Subjects
FATTY liver, LABORATORY mice, AGING, ANIMAL disease models, DRUG discovery, LIVER histology
Abstract

Background: Hepatocellular senescence may be a causal factor in the development and progression of non-alcoholic steatohepatitis (NASH). The most effective currently available treatment for NASH is lifestyle intervention, including dietary modification. This study aimed to evaluate the effects of dietary intervention on hallmarks of NASH and molecular signatures of hepatocellular senescence in the Gubra-Amylin NASH (GAN) diet-induced obese (DIO) and biopsy-confirmed mouse model of NASH. Methods: GAN DIO-NASH mice with liver biopsy-confirmed NASH and fibrosis received dietary intervention by switching to chow feeding (chow reversal) for 8, 16 or 24 weeks. Untreated GAN DIO-NASH mice and chow-fed C57BL/6J mice served as controls. Pre-to-post liver biopsy histology was performed for within-subject evaluation of NAFLD Activity Score and fibrosis stage. Terminal endpoints included blood/liver biochemistry, quantitative liver histology, mitochondrial respiration and RNA sequencing. Results: Chow-reversal promoted substantial benefits on metabolic outcomes and liver histology, as demonstrated by robust weight loss, complete resolution of hepatomegaly, hypercholesterolemia, elevated transaminase levels and hepatic steatosis in addition to attenuation of inflammatory markers. Notably, all DIO-NASH mice demonstrated ≥ 2 point significant improvement in NAFLD Activity Score following dietary intervention. While not improving fibrosis stage, chow-reversal reduced quantitative fibrosis markers (PSR, collagen 1a1, α-SMA), concurrent with improved liver mitochondrial respiration, complete reversal of p21 overexpression, lowered γ-H2AX levels and widespread suppression of gene expression markers of hepatocellular senescence. Conclusions: Dietary intervention (chow reversal) substantially improves metabolic, biochemical and histological hallmarks of NASH and fibrosis in GAN DIO-NASH mice. These benefits were reflected by progressive clearance of senescent hepatocellular cells, making the model suitable for profiling potential senotherapeutics in preclinical drug discovery for NASH. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Trends in health inequalities in 27 European countries

Author

Mackenbach, Johan P., Valverde, José Rubio, Artnik, Barbara, Bopp, Matthias, Brønnum-Hansen, Henrik, Deboosere, Patrick, Kalediene, Ramune, Kovács, Katalin, Leinsalu, Mall, Martikainen, Pekka, Menvielle, Gwenn, Regidor, Enrique, Rychtaříková, Jitka, Rodriguez-Sanz, Maica, Vineis, Paolo, White, Chris, Wojtyniak, Bogdan, Hu, Yannan, and Nusselder, Wilma J.

Published
2018

40. The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants

Author

Rio-Machin, Ana, Vulliamy, Tom, Hug, Nele, Walne, Amanda, Tawana, Kiran, Cardoso, Shirleny, Ellison, Alicia, Pontikos, Nikolas, Wang, Jun, Tummala, Hemanth, Al Seraihi, Ahad Fahad H., Alnajar, Jenna, Bewicke-Copley, Findlay, Armes, Hannah, Barnett, Michael, Bloor, Adrian, Bödör, Csaba, Bowen, David, Fenaux, Pierre, Green, Andrew, Hallahan, Andrew, Hjorth-Hansen, Henrik, Hossain, Upal, Killick, Sally, Lawson, Sarah, Layton, Mark, Male, Alison M., Marsh, Judith, Mehta, Priyanka, Mous, Rogier, Nomdedéu, Josep F., Owen, Carolyn, Pavlu, Jiri, Payne, Elspeth M., Protheroe, Rachel E., Preudhomme, Claude, Pujol-Moix, Nuria, Renneville, Aline, Russell, Nigel, Saggar, Anand, Sciuccati, Gabriela, Taussig, David, Toze, Cynthia L., Uyttebroeck, Anne, Vandenberghe, Peter, Schlegelberger, Brigitte, Ripperger, Tim, Steinemann, Doris, Wu, John, Mason, Joanne, Page, Paula, Akiki, Susanna, Reay, Kim, Cavenagh, Jamie D., Plagnol, Vincent, Caceres, Javier F., Fitzgibbon, Jude, and Dokal, Inderjeet

Published
2020
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42. Impact of the association between education and obesity on diabetes-free life expectancy.

Author

Brønnum-Hansen, Henrik, Davidsen, Michael, and Andersen, Ingelise

Subjects
*BODY weight, *LIFE expectancy, *DIABETES, *DESCRIPTIVE statistics, *RESEARCH funding, *EDUCATIONAL attainment
Abstract

Background The purpose of the study was to quantify the association between body weight and health by estimating the expected lifetime with and without diabetes (diabetes-free life expectancy) at age 30 and 65. In addition, the diabetes-free life expectancy was stratified by educational level. Methods Life tables by sex, level of education and obese/not obese were constructed using nationwide register data and self-reported data on body weight and height and diabetes from the Danish National Health Survey in 2021. Diabetes-free life expectancies were estimated by Sullivan's method. Results The difference in life expectancy between not obese 30-year-old men with a long and a short education was 5.7 years. For not obese women, the difference was 4.1 years. For obese men and women, the difference in life expectancy at age 30 was 7.0 and 5.2 years. Women could expect more years without and fewer years with diabetes than men regardless of body weight and educational level. Diabetes-free life expectancy differed by 6.9 years between not obese 30-year-old men with a short and a long education and by 7.7 years for obese men with a short and a long education. For women, the differences were 5.9 and 6.6 years. Conclusion The results demonstrate an association of obesity and educational level with life expectancy and diabetes-free life expectancy. There is a need for preventive efforts to reduce educational inequality in life expectancy and diabetes-free life expectancy. Structural intervention will particularly benefit overweight people with short education. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Randomized Comparison of the Polymer-Free Biolimus-Coated BioFreedom Stent With the Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Orsiro Stent in an All-Comers Population Treated With Percutaneous Coronary Intervention: The SORT OUT IX Trial

Author

Jensen, Lisette Okkels, Maeng, Michael, Raungaard, Bent, Kahlert, Johnny, Ellert, Julia, Jakobsen, Lars, Villadsen, Anton Boel, Veien, Karsten Tange, Kristensen, Steen Dalby, Ahlehoff, Ole, Carstensen, Steen, Christensen, Martin Kirk, Terkelsen, Christian Juhl, Engstroem, Thomas, Hansen, Knud Nørregaard, Bøtker, Hans Erik, Aaroe, Jens, Thim, Troels, Thuesen, Leif, Freeman, Philip, Aziz, Ahmed, Eftekhari, Ashkan, Junker, Anders, Jensen, Svend Eggert, Lassen, Jens Flensted, Hansen, Henrik Steen, and Christiansen, Evald Høj

Published
2020
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50. From land to sea: provenance, composition, and preservation of organic matter in a marine sediment record from the North‐East Greenland shelf spanning the Younger Dryas–Holocene.

Author

Andreasen, Nanna, Jackson, Rebecca, Rudra, Arka, Nøhr‐Hansen, Henrik, Sanei, Hamed, Bojesen‐Koefoed, Jørgen, Seidenkrantz, Marit‐Solveig, Pearce, Christof, Thibault, Nicolas, and Ribeiro, Sofia

Subjects
MARINE sediments, COASTAL sediments, ORGANIC compounds, PROVENANCE (Geology), YOUNGER Dryas, DINOFLAGELLATE cysts, ORGANIC geochemistry, GEOCHEMISTRY
Abstract

The organic matter content of marine sediments is often used to infer past changes in ocean conditions. However, the organic carbon pool preserved in coastal sediments is a complex mixture derived from different sources and may not reflect in situ processes. In this study, we combine taxonomic identification of reworked palynomorphs with pyrolysis organic geochemistry and reflected‐light organic petrographic microscopy to investigate the provenance, composition and preservation of organic matter in a marine sediment core retrieved from the NE Greenland shelf. Our study reveals continuous yet variable input of land‐derived organic carbon to the marine environment throughout the late Younger Dryas–Holocene, with the highest input of inert carbon in the late Younger Dryas. Although the sediments contain some recent marine palynomorphs, there is no other evidence of fresh marine organic carbon. In contrast, our results indicate that these shelf sediments represent a significant sink of recycled organic carbon. The results of pyrolysis geochemistry revealed that ~90% of the total organic carbon in the sediments is inert. The organic petrography analyses revealed that >70–84% of the organic carbon in the sediment core is terrigenous. Reworked dinoflagellate cysts showed a continuous provenance of Cretaceous land‐derived material, most likely from the nearby Clavering Island. Our study points to the importance of constraining the organic matter origin, composition and preservation in marine sediments to achieve more accurate palaeoenvironmental reconstructions based on organic proxies. [ABSTRACT FROM AUTHOR]

Published
2023
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