19 results on '"Chianese, Salvatore"'
Search Results
2. Prognostic Implications of Declining Hemoglobin Content in Patients Hospitalized With Acute Coronary Syndromes
- Author
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Leonardi, Sergio, Gragnano, Felice, Carrara, Greta, Gargiulo, Giuseppe, Frigoli, Enrico, Vranckx, Pascal, Di Maio, Dario, Spedicato, Vanessa, Monda, Emanuele, Fimiani, Luigi, Fioretti, Vincenzo, Esposito, Fabrizio, Avvedimento, Marisa, Magliulo, Fabio, Leone, Attilio, Chianese, Salvatore, Franzese, Michele, Scalise, Martina, Schiavo, Alessandra, Mazzone, Paolo, Esposito, Giovanni, Andò, Giuseppe, Calabrò, Paolo, Windecker, Stephan, and Valgimigli, Marco
- Published
- 2021
- Full Text
- View/download PDF
3. Use of Dual-Layered Stents for Carotid Artery Angioplasty: 1-Year Results of a Patient-Based Meta-Analysis
- Author
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Stabile, Eugenio, de Donato, Gianmarco, Musialek, Piotr, Deloose, Koen, Nerla, Roberto, Sirignano, Pasqualino, Mazurek, Adam, Mansour, Wassim, Fioretti, Vincenzo, Esposito, Fabrizio, Chianese, Salvatore, Bosiers, Marc, Setacci, Carlo, Speziale, Francesco, Micari, Antonio, and Esposito, Giovanni
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- 2020
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- View/download PDF
4. Use of Dual-Layered Stents in Endovascular Treatment of Extracranial Stenosis of the Internal Carotid Artery: Results of a Patient-Based Meta-Analysis of 4 Clinical Studies
- Author
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Stabile, Eugenio, de Donato, Gianmarco, Musialek, Piotr, De Loose, Koen, Nerla, Roberto, Sirignano, Pasqualino, Chianese, Salvatore, Mazurek, Adam, Tesorio, Tullio, Bosiers, Marc, Setacci, Carlo, Speziale, Francesco, Micari, Antonio, and Esposito, Giovanni
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- 2018
- Full Text
- View/download PDF
5. Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment.
- Author
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Mauro, Ciro, Capone, Valentina, Cocchia, Rosangela, Cademartiri, Filippo, Riccardi, Ferdinando, Arcopinto, Michele, Alshahid, Maie, Anwar, Kashif, Carafa, Mariano, Carbone, Andreina, Castaldo, Rossana, Chianese, Salvatore, Crisci, Giulia, D'Assante, Roberta, De Luca, Mariarosaria, Franzese, Monica, Galzerano, Domenico, Maffei, Vincenzo, Marra, Alberto M., and Valente, Valeria
- Subjects
EPIDERMAL growth factor receptors ,CANCER patients ,BREAST cancer ,ANTHRACYCLINES ,DAUNOMYCIN - Abstract
Cardiovascular (CV) diseases (CVD) are a major cause of long-term morbidity and mortality affecting life expectancy amongst cancer survivors. In recent years, because of the possibility of early diagnosis and the increased efficacy of neo-adjuvant and adjuvant systemic treatments (targeting specific molecular pathways), the high percentage of survival from breast cancer led CVD to become the first cause of death among survivors. Therefore, it is mandatory to adopt cardioprotective strategies to minimize CV side effects and CVD in general in breast cancer patients. Cancer therapeutics-related cardiac dysfunction (CTRCD) is a common group of side effects of chemotherapeutics widely employed in breast cancer (e.g., anthracycline and human epidermal growth factor receptor 2 inhibitors). The aim of the present manuscript is to propose a pragmatic multidisciplinary stepwise approach for prevention, early detection, and treatment of cardiotoxicity in patients with breast cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways.
- Author
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Mauro, Ciro, Capone, Valentina, Cocchia, Rosangela, Cademartiri, Filippo, Riccardi, Ferdinando, Arcopinto, Michele, Alshahid, Maie, Anwar, Kashif, Carafa, Mariano, Carbone, Andreina, Castaldo, Rossana, Chianese, Salvatore, Crisci, Giulia, D'Assante, Roberta, De Luca, Mariarosaria, Franzese, Monica, Galzerano, Domenico, Maffei, Vincenzo, Marra, Alberto Maria, and Mazza, Alfredo
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CARDIAC magnetic resonance imaging ,HEALTH care teams ,CARDIOTOXICITY ,NATRIURETIC peptides ,EARLY detection of cancer - Abstract
Early detection and treatment of cancer have led to a noticeable reduction in both mortality and morbidity. However, chemotherapy and radiotherapy could exert cardiovascular (CV) side effects, impacting survival and quality of life, independent of the oncologic prognosis. In this regard, a high clinical index of suspicion is required by the multidisciplinary care team in order to trigger specific laboratory tests (namely natriuretic peptides and high-sensitivity cardiac troponin) and appropriate imaging techniques (transthoracic echocardiography along with cardiac magnetic resonance, cardiac computed tomography, and nuclear testing (if clinically indicated)), leading to timely diagnosis. In the near future, we do expect a more tailored approach to patient care within the respective community along with the widespread implementation of digital health tools. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
- View/download PDF
7. Acute Heart Failure: Diagnostic–Therapeutic Pathways and Preventive Strategies—A Real-World Clinician's Guide.
- Author
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Mauro, Ciro, Chianese, Salvatore, Cocchia, Rosangela, Arcopinto, Michele, Auciello, Stefania, Capone, Valentina, Carafa, Mariano, Carbone, Andreina, Caruso, Giuseppe, Castaldo, Rossana, Citro, Rodolfo, Crisci, Giulia, D'Andrea, Antonello, D'Assante, Roberta, D'Avino, Maria, Ferrara, Francesco, Frangiosa, Antonio, Galzerano, Domenico, Maffei, Vincenzo, and Marra, Alberto Maria
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MEDICAL personnel , *ARTIFICIAL blood circulation , *SYMPTOMS , *CARDIAC output , *MEDICAL care costs , *CARDIOGENIC shock - Abstract
Acute heart failure (AHF) is the most frequent cause of unplanned hospital admission in patients of >65 years of age and it is associated with significantly increased morbidity, mortality, and healthcare costs. Different AHF classification criteria have been proposed, mainly reflecting the clinical heterogeneity of the syndrome. Regardless of the underlying mechanism, peripheral and/or pulmonary congestion is present in the vast majority of cases. Furthermore, a marked reduction in cardiac output with peripheral hypoperfusion may occur in most severe cases. Diagnosis is made on the basis of signs and symptoms, laboratory, and non-invasive tests. After exclusion of reversible causes, AHF therapeutic interventions mainly consist of intravenous (IV) diuretics and/or vasodilators, tailored according to the initial hemodynamic status with the addition of inotropes/vasopressors and mechanical circulatory support if needed. The aim of this review is to discuss current concepts on the diagnosis and management of AHF in order to guide daily clinical practice and to underline the unmet needs. Preventive strategies are also discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
8. Severe Stenosis of Mitral Bioprosthetic Valve Thrombosis in a Patient with HCV-Related Cirrhosis and Duodenal Variceal Bleeding: The Deadly Triad.
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Cocchia, Rosangela, Chianese, Salvatore, Lombardi, Giovanni, Romano, Luigia, Capone, Valentina, Amitrano, Lucio, Bennato, Raffaele, Ranieri, Brigida, Russo, Giuseppe, Mauro, Ciro, and Bossone, Eduardo
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MITRAL stenosis , *BIOPROSTHETIC heart valves , *THROMBOSIS , *MITRAL valve , *HEMORRHAGE , *DUODENAL obstructions , *MITRAL valve insufficiency - Abstract
Bioprosthetic valve thrombosis (BPVT) is considered a relatively rare but life-threatening clinical entity. Thus, there is the need of high clinical suspicion in order to make a timely diagnosis and related appropriate therapeutic interventions. In this regard, the management of BPVT is high risk, whatever the option taken (surgery and/or systemic fibrinolysis). The presence of severe comorbidities—as decompensated cirrhosis—further complicates the clinical decision-making process, calling for a patient-tailored integrated multidisciplinary approach. We report a challenging case of a 45-year-old patient with mitral bioprosthetic valve thrombosis and hepatitis C virus (HCV)-related cirrhosis complicated by active duodenal variceal bleeding. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Effects of Exercise on Heart Failure with Preserved Ejection Fraction: An Updated Review of Literature.
- Author
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Crisci, Giulia, De Luca, Mariarosaria, D'Assante, Roberta, Ranieri, Brigida, D'Agostino, Anna, Valente, Valeria, Giardino, Federica, Capone, Valentina, Chianese, Salvatore, Rega, Salvatore, Cocchia, Rosangela, Israr, Muhammad Zubair, Debiek, Radek, Heaney, Liam M., and Salzano, Andrea
- Published
- 2022
- Full Text
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10. Physiologic Range of Myocardial Mechano-Energetic Efficiency among Healthy Subjects: Impact of Gender and Age.
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Ferrara, Francesco, Capone, Valentina, Cademartiri, Filippo, Vriz, Olga, Cocchia, Rosangela, Ranieri, Brigida, Franzese, Monica, Castaldo, Rossana, D'Andrea, Antonello, Citro, Rodolfo, Chianese, Salvatore, Annunziata, Roberto, Marullo, Flavio, Siniscalchi, Mario, Conte, Marianna, Sepe, Chiara, Maramaldi, Renato, Rega, Salvatore, Russo, Giuseppe, and Majolo, Massimo
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DIASTOLIC blood pressure ,BODY surface area ,HEART metabolism ,HEART beat ,CARDIOVASCULAR system physiology ,GENDER ,DIASTOLE (Cardiac cycle) - Abstract
Background: Myocardial mechano-energetic efficiency (MEE) is the capability of the left ventricle (LV) to convert the chemical energy obtained from the cardiac oxidative metabolism into mechanical work. The aim of present study was to establish normal non-invasive MEE and MEEi reference values. Methods: In total, 1168 healthy subjects underwent physical examinations, clinical assessment, and standardized transthoracic echocardiographic (TTE) examination. MEE was obtained by TTE as the ratio between stroke volume (SV) and heart rate (HR): MEE = SV/HR [HR expressed in seconds (HR/60)]. Because MEE is highly related to left ventricular mass (LVM), MEE was then divided by LVM with the purpose of obtaining an estimate of energetic expenditure per unit of myocardial mass (i.e., indexed MEE, MEEi, mL/s/g). Results: The mean values of MEE and MEEi in the overall population were 61.09 ± 18.19 mL/s; 0.45 ± 0.14, respectively. In a multivariable analysis, gender, body surface area (BSA), diastolic blood pressure, left atrial volume indexed to BSA, E/e' and tricuspid annular plane systolic excursion (TAPSE) were the independent variables associated with MEE, while age, gender, BSA and TAPSE were the independent variables associated with MEEi. Conclusions: The knowledge of age- and gender-based MEE and MEEi normal values may improve the global assessment of LV cardiac mechanics and serve as a reference to identify phenotypes at high risk of cardiovascular events. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
11. Successful surgical repair of left ventricular pseudoaneurysm in a patient with subacute ST-elevation myocardial infarction.
- Author
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Cocchia, Rosangela, Iannelli, Gabriele, Capone, Valentina, Chianese, Salvatore, Langella, Giuseppina, Ranieri, Brigida, Majolo, Massimo, Russo, Giuseppe, Pilato, Emanuele, Mauro, Ciro, and Bossone, Eduardo
- Subjects
ST elevation myocardial infarction ,FALSE aneurysms ,SUBACUTE care - Abstract
We report a successful surgical repair of left ventricular pseudoaneurysm in a patient with subacute ST-elevation myocardial infarction (STEMI). In the case of expansion of the infarct related ventricular wall, early (within 24 hours) or late (3-5 days after STEMI) cardiac rupture should be always borne in mind in order to proceed to life saving prompt surgical repair. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
12. Cardiac teleconsulting in the time of COVID-19 global pandemic: The "Antonio Cardarelli" Hospital project.
- Author
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Bossone, Eduardo, Mauro, Ciro, Maiellaro, Alfonso, Raiola, Eliana, Cocchia, Rosangela, Ranieri, Brigida, Sepe, Chiara, Capone, Valentina, Chianese, Salvatore, Maramaldi, Renato, Acerra, Enrico Pasquale, Mirto, Gaetano, Lodato, Sergio, Russo, Giuseppe, and Longo, Giuseppe
- Subjects
COVID-19 pandemic ,MEDICAL personnel ,CORONARY artery disease ,CARDIAC patients ,HEART valve diseases ,PULMONARY embolism ,CARDIOLOGISTS ,STROKE - Published
- 2021
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13. Right Heart Pulmonary Circulation Unit Response to Exercise in Patients with Controlled Systemic Arterial Hypertension: Insights from the RIGHT Heart International NETwork (RIGHT-NET).
- Author
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Vriz, Olga, Palatini, Paolo, Rudski, Lawrence, Frumento, Paolo, Kasprzak, Jarosław D., Ferrara, Francesco, Cocchia, Rosangela, Gargani, Luna, Wierzbowska-Drabik, Karina, Capone, Valentina, Ranieri, Brigida, Salzano, Andrea, Stanziola, Anna Agnese, Marra, Alberto Maria, Annunziata, Roberto, Chianese, Salvatore, Rega, Salvatore, Saltalamacchia, Teresa, Maramaldi, Renato, and Sepe, Chiara
- Subjects
CORONARY circulation ,PULMONARY circulation ,DOPPLER echocardiography ,HYPERTENSION ,DIASTOLIC blood pressure - Abstract
Background. Systemic arterial hypertension (HTN) is the main risk factor for the development of heart failure with preserved ejection fraction (HFpEF). The aim of the study was was to assess the trends in PASP, E/E' and TAPSE during exercise Doppler echocardiography (EDE) in hypertensive (HTN) patients vs. healthy subjects stratified by age. Methods. EDE was performed in 155 hypertensive patients and in 145 healthy subjects (mean age 62 ± 12.0 vs. 54 ± 14.9 years respectively, p < 0.0001). EDE was undertaken on a semi-recumbent cycle ergometer with load increasing by 25 watts every 2 min. Left ventricular (LV) and right ventricular (RV) dimensions, function and hemodynamics were evaluated. Results. Echo-Doppler parameters of LV and RV function were lower, both at rest and at peak exercise in hypertensives, while pulmonary hemodynamics were higher as compared to healthy subjects. The entire cohort was then divided into tertiles of age: at rest, no significant differences were recorded for each age group between hypertensives and normotensives except for E/E' that was higher in hypertensives. At peak exercise, hypertensives had higher pulmonary artery systolic pressure (PASP) and E/E' but lower tricuspid annular plane systolic excursion (TAPSE) as age increased, compared to normotensives. Differences in E/E' and TAPSE between the 2 groups at peak exercise were explained by the interaction between HTN and age even after adjustment for baseline values (p < 0.001 for E/E', p = 0.011 for TAPSE). At peak exercise, the oldest group of hypertensive patients had a mean E/E' of 13.0, suggesting a significant increase in LV diastolic pressure combined with increased PASP. Conclusion. Age and HTN have a synergic negative effect on E/E' and TAPSE at peak exercise in hypertensive subjects. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
14. Reference Ranges of Left Ventricular Hemodynamic Forces in Healthy Adults: A Speckle-Tracking Echocardiographic Study.
- Author
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Ferrara, Francesco, Capuano, Francesco, Cocchia, Rosangela, Ranieri, Brigida, Contaldi, Carla, Lacava, Graziella, Capone, Valentina, Chianese, Salvatore, Rega, Salvatore, Annunziata, Roberto, Sepe, Chiara, Salzano, Andrea, Citro, Rodolfo, D'Andrea, Antonello, Mauro, Ciro, Cademartiri, Filippo, Pedrizzetti, Gianni, and Bossone, Eduardo
- Subjects
HEMODYNAMICS ,SPECKLE tracking echocardiography ,HEART beat ,ADULTS ,REFERENCE values - Abstract
Background: The normal limits of left ventricular (LV) hemodynamic forces (HDFs) are not exactly known. The aim of this study was to explore the full spectrum of HDF parameters in healthy subjects and determine their physiologic correlates. Methods: 269 healthy subjects were enrolled (mean age: 43 ± 14 years; 123 (45.7%) men). All participants underwent an echo-Doppler examination. Tri-plane tissue tracking from apical views was used to measure 2D global endocardial longitudinal strain (GLS), circumferential strain (GCS), and LV HDFs. HDFs were normalized with LV volume and divided by specific weight. Results: LV systolic longitudinal HDFs (%) were higher in men (20.8 ± 6.5 vs. 18.9 ± 5.6, p = 0.009; 22.0 ± 6.7 vs. 19.8 ± 5.6, p = 0.004, respectively). There was a significant correlation between GCS (increased) (r = −0.240, p < 0.001) and LV longitudinal HDFs (reduced) (r = −0.155, p = 0.01) with age. In a multivariable analysis age, BSA, pulse pressure, heart rate and GCS were the only independent variables associated with LV HDFs (β coefficient = −0.232, p < 0.001; 0.149, p = 0.003; 0.186, p < 0.001; 0.396, p < 0.001; −0.328, p < 0.001; respectively). Conclusion: We report on the physiologic range of LV HDFs. Knowledge of reference values of HDFs may prompt their implementation into clinical routine and allow a more comprehensive assessment of the LV function. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
15. Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment
- Author
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Ciro Mauro, Valentina Capone, Rosangela Cocchia, Filippo Cademartiri, Ferdinando Riccardi, Michele Arcopinto, Maie Alshahid, Kashif Anwar, Mariano Carafa, Andreina Carbone, Rossana Castaldo, Salvatore Chianese, Giulia Crisci, Roberta D’Assante, Mariarosaria De Luca, Monica Franzese, Domenico Galzerano, Vincenzo Maffei, Alberto M. Marra, Valeria Valente, Federica Giardino, Alfredo Mazza, Brigida Ranieri, Anna D’Agostino, Salvatore Rega, Luigia Romano, Sarah Scagliarini, Chiara Sepe, Olga Vriz, Raffaele Izzo, Antonio Cittadini, Eduardo Bossone, Andrea Salzano, Mauro, Ciro, Capone, Valentina, Cocchia, Rosangela, Cademartiri, Filippo, Riccardi, Ferdinando, Arcopinto, Michele, Alshahid, Maie, Anwar, Kashif, Carafa, Mariano, Carbone, Andreina, Castaldo, Rossana, Chianese, Salvatore, Crisci, Giulia, D'Assante, Roberta, De Luca, Mariarosaria, Franzese, Monica, Galzerano, Domenico, Maffei, Vincenzo, Marra, Alberto M, Valente, Valeria, Giardino, Federica, Mazza, Alfredo, Ranieri, Brigida, D'Agostino, Anna, Rega, Salvatore, Romano, Luigia, Scagliarini, Sarah, Sepe, Chiara, Vriz, Olga, Izzo, Raffaele, Cittadini, Antonio, Bossone, Eduardo, and Salzano, Andrea
- Subjects
breast cancer ,cardio-oncology ,prevention ,cardiotoxicity ,General Medicine - Abstract
Cardiovascular (CV) diseases (CVD) are a major cause of long-term morbidity and mortality affecting life expectancy amongst cancer survivors. In recent years, because of the possibility of early diagnosis and the increased efficacy of neo-adjuvant and adjuvant systemic treatments (targeting specific molecular pathways), the high percentage of survival from breast cancer led CVD to become the first cause of death among survivors. Therefore, it is mandatory to adopt cardioprotective strategies to minimize CV side effects and CVD in general in breast cancer patients. Cancer therapeutics-related cardiac dysfunction (CTRCD) is a common group of side effects of chemotherapeutics widely employed in breast cancer (e.g., anthracycline and human epidermal growth factor receptor 2 inhibitors). The aim of the present manuscript is to propose a pragmatic multidisciplinary stepwise approach for prevention, early detection, and treatment of cardiotoxicity in patients with breast cancer.
- Published
- 2023
16. Acute Heart Failure: Diagnostic-Therapeutic Pathways and Preventive Strategies-A Real-World Clinician's Guide
- Author
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Ciro Mauro, Salvatore Chianese, Rosangela Cocchia, Michele Arcopinto, Stefania Auciello, Valentina Capone, Mariano Carafa, Andreina Carbone, Giuseppe Caruso, Rossana Castaldo, Rodolfo Citro, Giulia Crisci, Antonello D’Andrea, Roberta D’Assante, Maria D’Avino, Francesco Ferrara, Antonio Frangiosa, Domenico Galzerano, Vincenzo Maffei, Alberto Maria Marra, Rahul M. Mehta, Rajendra H. Mehta, Fiorella Paladino, Brigida Ranieri, Monica Franzese, Giuseppe Limongelli, Salvatore Rega, Luigia Romano, Andrea Salzano, Chiara Sepe, Olga Vriz, Raffaele Izzo, Filippo Cademartiri, Antonio Cittadini, Eduardo Bossone, Mauro, Ciro, Chianese, Salvatore, Cocchia, Rosangela, Arcopinto, Michele, Auciello, Stefania, Capone, Valentina, Carafa, Mariano, Carbone, Andreina, Caruso, Giuseppe, Castaldo, Rossana, Citro, Rodolfo, Crisci, Giulia, D'Andrea, Antonello, D'Assante, Roberta, D'Avino, Maria, Ferrara, Francesco, Frangiosa, Antonio, Galzerano, Domenico, Maffei, Vincenzo, Marra, Alberto Maria, Mehta, Rahul M, Mehta, Rajendra H, Paladino, Fiorella, Ranieri, Brigida, Franzese, Monica, Limongelli, Giuseppe, Rega, Salvatore, Romano, Luigia, Salzano, Andrea, Sepe, Chiara, Vriz, Olga, Izzo, Raffaele, Cademartiri, Filippo, Cittadini, Antonio, and Bossone, Eduardo
- Subjects
cardiac ultrasound ,acute heart failure ,computer tomography ,biomarker ,General Medicine ,therapeutic interventions ,preventive strategie - Abstract
Acute heart failure (AHF) is the most frequent cause of unplanned hospital admission in patients of >65 years of age and it is associated with significantly increased morbidity, mortality, and healthcare costs. Different AHF classification criteria have been proposed, mainly reflecting the clinical heterogeneity of the syndrome. Regardless of the underlying mechanism, peripheral and/or pulmonary congestion is present in the vast majority of cases. Furthermore, a marked reduction in cardiac output with peripheral hypoperfusion may occur in most severe cases. Diagnosis is made on the basis of signs and symptoms, laboratory, and non-invasive tests. After exclusion of reversible causes, AHF therapeutic interventions mainly consist of intravenous (IV) diuretics and/or vasodilators, tailored according to the initial hemodynamic status with the addition of inotropes/vasopressors and mechanical circulatory support if needed. The aim of this review is to discuss current concepts on the diagnosis and management of AHF in order to guide daily clinical practice and to underline the unmet needs. Preventive strategies are also discussed.
- Published
- 2023
17. Prognostic Implications of Declining Hemoglobin Content in Patients Hospitalized With Acute Coronary Syndromes
- Author
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Felice Gragnano, Marco Valgimigli, Michele Franzese, Fabrizio Esposito, Giuseppe Gargiulo, Marisa Avvedimento, Vincenzo Fioretti, Sergio Leonardi, Vanessa Spedicato, Giuseppe Andò, Fabio Magliulo, Paolo Calabrò, Attilio Leone, Martina Scalise, Stephan Windecker, Alessandra Schiavo, Paolo Mazzone, Greta Carrara, Pascal Vranckx, Salvatore Chianese, Giovanni Esposito, Luigi Fimiani, Emanuele Monda, Enrico Frigoli, Dario Di Maio, Leonardi, S., Gragnano, F., Carrara, G., Gargiulo, G., Frigoli, E., Vranckx, P., Di Maio, D., Spedicato, V., Monda, E., Fimiani, L., Fioretti, V., Esposito, F., Avvedimento, M., Magliulo, F., Leone, A., Chianese, S., Franzese, M., Scalise, M., Schiavo, A., Mazzone, P., Esposito, G., Ando, G., Calabro, P., Windecker, S., Valgimigli, M., Leonardi, Sergio, Gragnano, Felice, Carrara, Greta, Gargiulo, Giuseppe, Frigoli, Enrico, Vranckx, Pascal, Di Maio, Dario, Spedicato, Vanessa, Monda, Emanuele, Fimiani, Luigi, Fioretti, Vincenzo, Esposito, Fabrizio, Avvedimento, Marisa, Magliulo, Fabio, Leone, Attilio, Chianese, Salvatore, Franzese, Michele, Scalise, Martina, Schiavo, Alessandra, Mazzone, Paolo, Esposito, Giovanni, Andò, Giuseppe, Calabrò, Paolo, Windecker, Stephan, and Valgimigli, Marco
- Subjects
Male ,medicine.medical_specialty ,Acute coronary syndrome ,Randomization ,medicine.medical_treatment ,Hemorrhage ,030204 cardiovascular system & hematology ,acute coronary syndrome ,03 medical and health sciences ,Hemoglobins ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,In patient ,030212 general & internal medicine ,610 Medicine & health ,Aged ,Aged, 80 and over ,Inpatients ,business.industry ,Incidence (epidemiology) ,Hazard ratio ,percutaneous coronary intervention ,Percutaneous coronary intervention ,Middle Aged ,hemoglobin ,medicine.disease ,Prognosis ,bleeding ,Confidence interval ,Europe ,Cardiology ,Female ,Hemoglobin ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND Contemporary definitions of bleeding endpoints are restricted mostly to clinically overt events. Whether hemoglobin drop per se, with or without overt bleeding, adversely affects the prognosis of patients with acute coronary syndrome (ACS) remains unclear. OBJECTIVES The aim of this study was to examine in the MATRIX (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial the incidence, predictors, and prognostic implications of in-hospital hemoglobin drop in patients with ACS managed invasively stratified by the presence of in-hospital bleeding. METHODS Patients were categorized by the presence and amount of in-hospital hemoglobin drop on the basis of baseline and nadir hemoglobin values and further stratified by the occurrence of adjudicated in-hospital bleeding. Hemoglobin drop was defined as minimal (
- Published
- 2021
18. Preoperative Assessment and Management of Cardiovascular Risk in Patients Undergoing Non-Cardiac Surgery: Implementing a Systematic Stepwise Approach during the COVID-19 Pandemic Era.
- Author
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Bossone E, Cademartiri F, AlSergani H, Chianese S, Mehta R, Capone V, Ruotolo C, Tarrar IH, Frangiosa A, Vriz O, Maffei V, Annunziata R, Galzerano D, Ranieri B, Sepe C, Salzano A, Cocchia R, Majolo M, Russo G, Longo G, Muto M, Fedelini P, Esposito C, Perrella A, Guggino G, Raiola E, Catalano M, De Palma M, Romano L, Romano G, Coppola C, Mauro C, and Mehta RH
- Abstract
Major adverse cardiac events, defined as death or myocardial infarction, are common causes of perioperative mortality and major morbidity in patients undergoing non-cardiac surgery. Reduction of perioperative cardiovascular risk in relation to non-cardiac surgery requires a stepwise patient evaluation that integrates clinical risk factors, functional status and the estimated stress of the planned surgical procedure. Major guidelines on preoperative cardiovascular risk assessment recommend to establish, firstly, the risk of surgery per se (low, moderate, high) and the related timing (elective vs. urgent/emergent), evaluate the presence of unstable cardiac conditions or a recent coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting), assess the functional capacity of the patient (usually expressed in metabolic equivalents), determine the value of non-invasive and/or invasive cardiovascular testing and then combine these data in estimating perioperative risk for major cardiac adverse events using validated scores (Revised Cardiac Risk Index (RCRI) or National Surgical Quality Improvement Program (NSQIP)). This stepwise approach has the potential to guide clinicians in determining which patients could benefit from cardiovascular therapy and/or coronary artery revascularization before non-cardiac surgery towards decreasing the incidence of perioperative morbidity and mortality. Finally, it should be highlighted that there is a need to implement specific strategies in the 2019 Coronavirus disease (COVID-19) pandemic to minimize the risk of transmission of COVID-19 infection during the preoperative risk assessment process.
- Published
- 2021
- Full Text
- View/download PDF
19. Successful surgical repair of left ventricular pseudoaneurysm in a patient with subacute ST-elevation myocardial infarction.
- Author
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Cocchia R, Iannelli G, Capone V, Chianese S, Langella G, Ranieri B, Majolo M, Russo G, Pilato E, Mauro C, and Bossone E
- Subjects
- Heart Ventricles diagnostic imaging, Heart Ventricles surgery, Humans, Aneurysm, False complications, Aneurysm, False diagnostic imaging, Aneurysm, False surgery, ST Elevation Myocardial Infarction surgery
- Abstract
We report a successful surgical repair of left ventricular pseudoaneurysm in a patient with subacute ST-elevation myocardial infarction (STEMI). In the case of expansion of the infarct related ventricular wall, early (within 24 hours) or late (3-5 days after STEMI) cardiac rupture should be always borne in mind in order to proceed to life saving prompt surgical repair.
- Published
- 2021
- Full Text
- View/download PDF
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