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With the emergence of precision medicine, estimating optimal individualized decision rules (IDRs) has attracted tremendous attention in many scientific areas. Most existing literature has focused on finding optimal IDRs that can maximize the expected outcome for each individual. Motivated by complex individualized decision making procedures and the popular conditional value at risk (CVaR) measure, we propose a new robust criterion to estimate optimal IDRs in order to control the average lower tail of the individuals' outcomes. In addition to improving the individualized expected outcome, our proposed criterion takes risks into consideration, and thus the resulting IDRs can prevent adverse events. The optimal IDR under our criterion can be interpreted as the decision rule that maximizes the "worst-case" scenario of the individualized outcome when the underlying distribution is perturbed within a constrained set. An efficient non-convex optimization algorithm is proposed with convergence guarantees. We investigate theoretical properties for our estimated optimal IDRs under the proposed criterion such as consistency and finite sample error bounds. Simulation studies and a real data application are used to further demonstrate the robust performance of our methods. Several extensions of the proposed method are also discussed. for this article are available online. [ABSTRACT FROM AUTHOR]

In combination with Bayesian estimates based on a population pharmacokinetic model, limited sampling strategies (LSS) may reduce the number of samples required for individual pharmacokinetic parameter estimations. Such strategies reduce the burden when assessing the area under the concentration versus time curves (AUC) in therapeutic drug monitoring. However, it is not uncommon for the actual sample time to deviate from the optimal one. In this work, we evaluate the robustness of parameter estimations to such deviations in an LSS. A previously developed 4-point LSS for estimation of serum iohexol clearance (i.e., dose/AUC) was used to exemplify the effect of sample time deviations. Two parallel strategies were used: (a) shifting the exact sampling time by an empirical amount of time for each of the four individual sample points, and (b) introducing a random error across all sample points. The investigated iohexol LSS appeared robust to deviations from optimal sample times, both across individual and multiple sample points. The proportion of individuals with a relative error greater than 15% (P15) was 5.3% in the reference run with optimally timed sampling, which increased to a maximum of 8.3% following the introduction of random error in sample time across all four time points. We propose to apply the present method for the validation of LSS developed for clinical use. [ABSTRACT FROM AUTHOR]

Fuzzy extractor (FE) extracts and reproduces a uniform string from a fuzzy source. Robustly reusable fuzzy extractor (rrFE) considers reusability and robustness simultaneously. Reusability of rrFE allows multiple extractions of pseudorandom strings from the same source and robustness detects active attacks. To achieve reusability and robustness, the existing constructions of rrFE make heavy use of perfect random coins (which are uniformly distributed and independent of each other), besides the fuzzy source. However, efficiently sampling unbiased random bits only exists in the ideal world. In this paper, we show how to construct rrFE resorting to imperfect randomness (non-uniform but of high entropy), which is easy to sample in practice. We propose two generic constructions of rrFE in the CRS model, with one construction dealing with perfect randomness and the other dealing with imperfect randomness. We also present two instantiations of rrFE from the DDH and LPN assumptions working with perfect randomness, and another two instantiations of rrFE from DDH and LPN working with imperfect randomness. All instantiations support linear fraction of errors between samples of the fuzzy source. Our DDH-based rrFE (both rrFE with perfect randomness and rrFE with imperfect randomness) are the first tightly secure rrFEs in the standard model, i.e., the reusability and robustness are tightly reduced to the DDH assumption. Compared with the DDH-based rrFE scheme in PKC2019 by Wen et al., our rrFE enjoys tighter security, better efficiency, and support of usage of imperfect randomness. Our LPN-based rrFE (both rrFE with perfect randomness and rrFE with imperfect randomness) are the first rrFEs from the LPN assumption in the standard model. [ABSTRACT FROM AUTHOR]

Evaluating the importance and the strength of empirical evidence requires asking three questions: First, what are the practical implications of the findings? Second, how precise are the estimates? Confidence intervals provide an intuitive way to communicate precision. Although nontechnical audiences often misinterpret confidence intervals (CIs), I argue that the result is less dangerous than the misunderstandings that arise from hypothesis tests. Third, is the model correctly specified? The validity of point estimates and CIs depends on the soundness of the underlying model. [ABSTRACT FROM AUTHOR]

This paper investigates the distributed federated Tobit Kalman filter fusion problem for a class of discrete-time systems subject to measurement censoring and packet delays. The censored measurement is characterized by the Tobit measurement model and the packet delay obeys the Poisson distribution. At the input terminal of each local estimator, a censoring detection device and a buffer with finite length are exploited to tackle the censored/delayed measurements. The filtering fusion is carried out in two steps: in the first step, every sensor in the network collects and sends its measurements to the corresponding local estimator via an unreliable network with probabilistic packet delays and, in the second step, the estimates from local estimators are further collected by the fusion center to form a fused estimate. The local estimator runs a modified Tobit Kalman filtering algorithm, which is designed based on the modified Tobit regression model, while the fusion center performs a distributed federated modified Tobit Kalman filtering algorithm, which is devised on the basis of the federated Kalman fusion rule. Given the buffer length, the prescribed bound on the estimation error covariance and the probability distribution of the packet delay, the stability performance of the proposed filtering fusion algorithm is evaluated via a probabilistic approach. Simulation results are provided to show the feasibility of the proposed filter. [ABSTRACT FROM AUTHOR]

The control of automobile electronic throttle (AET) systems is a challenging task owing to multiple nonlinearities, i.e., transmission friction, gear backlash, limp-home spring set, and external load disturbance. In this paper, a practical tracking control scheme of an AET system is developed using a continuous fast nonsingular terminal sliding mode (CFNTSM) technique based on uncertainty observer. By using the prescribed CFNTSM surface and fast terminal sliding mode-based reaching element, the proposed control implementation guarantees the fast error convergence characteristic and high tracking accuracy under parameter uncertainties and perturbations. Furthermore, due to the adoption of the finite-time exact observer (FEO) for the lumped uncertainty estimation in the controller, the ease of the selection of the control gains is well-achieved since they only depend on the uncertainty estimation error. The closed-loop stability and finite-time convergence are presented based on the Lyapunov stability theory. Experimental verifications are conducted to validate the remarkable performance of the proposed control, in terms of the step and sinusoidal tracking as well as anti-disturbance ability. [ABSTRACT FROM PUBLISHER]

This paper introduces a method to monitor battery state of health (SOH) by estimating the number of cyclable Li-ions, a health-relevant electrochemical variable. SOH monitoring is critical to battery management in balancing the trade-off between maximizing system performance and minimizing battery degradation. The decrease of cyclable Li-ions indicates the effect on the SOH of degradation mechanisms that consume cyclable Li-ions. The unavailability of the number of cyclable Li-ions through non-invasive measurements makes its estimation necessary for in-situ SOH monitoring. In this paper, the extended Kalman filter (EKF) is used to estimate the number of cyclable Li-ions as an unknown battery parameter. The single particle model (SPM), a simplified battery electrochemical model, is used as the model in the EKF to achieve a computational complexity suitable for on-line estimation. Simulations are performed under typical electric vehicle current trajectories using an example parameter set for a hybrid-electric-vehicle battery. In the simulations, the battery is represented by the Doyle–Fuller–Newman (DFN) model, an electrochemical model with higher fidelity than the SPM. To comply with the practice, instead of using the same parameters as the DFN model in the SPM, parameterization of the SPM is performed before estimation of the number of cyclable Li-ions. The simulations show high estimation accuracy of the number of cyclable Li-ions using the EKF, even with the structural and parametric differences between the DFN model and the SPM, under both the ideal conditions and various non-ideal conditions (i.e., SOC estimation error, additional modeling error, and measurement noise). [ABSTRACT FROM AUTHOR]

Deadbeat control (DBC) is developed based on the system model, which is commonly used to achieve good control performance for a three-phase grid connected converter (GCC). Unbalanced grid voltage is a common phenomenon in power systems. In this study, an improved DBC based on current predictive correction (CPC_DBC) is used to control GCC under an unbalanced grid voltage. The main purposes of CPC_DBC are to reduce the adverse effects due to random sampling error to improve current control performance, and to enhance the interference rejection capability of the control system. Then, the characteristics of CPC_DBC and the conventional DBC (Con_DBC) are analyzed by transfer functions in the discrete time domain. Several common control objectives under an unbalanced grid voltage are used to demonstrate the superiority of CPC_DBC. Finally, the experimental results indicate that CPC_DBC can effectively reduce the adverse effects of random sampling error; the robustness of system due to the uncertain value of the filter inductance is improved as well. [ABSTRACT FROM PUBLISHER]

Fast capacity estimation is a key enabling technique for second-life of lithium-ion batteries due to the hard work involved in determining the capacity of a large number of used electric vehicle (EV) batteries. This paper tries to make three contributions to the existing literature through a robust and advanced algorithm: (1) a three layer back propagation artificial neural network (BP ANN) model is developed to estimate the battery capacity. The model employs internal resistance expressing the battery's kinetics as the model input, which can realize fast capacity estimation; (2) an estimation error model is established to investigate the relationship between the robustness coefficient and regression coefficient. It is revealed that commonly used ANN capacity estimation algorithm is flawed in providing robustness of parameter measurement uncertainties; (3) the law of large numbers is used as the basis for a proposed robust estimation approach, which optimally balances the relationship between estimation accuracy and disturbance rejection. An optimal range of the threshold for robustness coefficient is also discussed and proposed. Experimental results demonstrate the efficacy and the robustness of the BP ANN model together with the proposed identification approach, which can provide an important basis for large scale applications of second-life of batteries. [ABSTRACT FROM AUTHOR]