1. Unconventional approaches for chiral resolution.
- Author
-
Malacarne, Filippo, Grecchi, Sara, Niamlaem, Malinee, Bonczak, Bartlomiej, Salinas, Gerardo, and Arnaboldi, Serena
- Subjects
- *
RESOLUTION (Chemistry) , *CHIRALITY , *ELECTROPHORESIS , *MOLECULES , *CHROMATOGRAPHIC analysis - Abstract
Chirality is a fundamental and ubiquitous property of nature involved in multiple fields of science. In particular, the possible resolution of the enantiomeric forms of a molecule is crucial in the pharmaceutical, food, and agrochemical industries. The search for efficient, broad-spectrum, and yet simple methods for obtaining enantiomerically pure substances is a current challenge. Enantioselective resolution methods rely on an asymmetric environment that allows the two antipodes of a chiral molecule to be distinguished. In addition to enantiomeric separation techniques, such as chromatography and electrophoresis, new promising approaches involving out-of-the-scheme synergistic effects between chiral selectors (CS) and external stimuli are emerging. This Trends article discusses different enantioselective mechanisms triggered by unconventional physicochemical stimuli for the design of avant-garde approaches that could offer novel perspectives in the field of chiral resolution. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF