13 results on '"Mannaerts, Guido"'
Search Results
2. Twelve-year outcomes of watchful waiting versus surgery of mildly symptomatic or asymptomatic inguinal hernia in men aged 50 years and older: a randomised controlled trial
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van den Dop, Matthijs, van Egmond, Sarah, Heijne, Jort, van Rosmalen, Joost, Tanis, Pieter, de Goede, Barry, Kleinrensink, Gert-Jan, Jeekel, Johannes, Lange, Johan F., Van Ramshorst, Gabrielle H., Klitsie, Pieter J., van Kempen, Bob J.H., Hunink, Myriam G.M., Hop, Wim C., Halm, Jens A., Burger, Pim J.W.A., Brandt, Alexandra, Franssen, Gaston J.H., Oomen, Jan, Wijsmuller, Arthur R., Roumen, Rudi M.H., Schelting, Marc R.M., Boelens, Oliver, Susa, Denis, Verhagen, Tim, Rath, Hiltjo J., Lont, Harold E., Mannaerts, Guido H., de Haan, Jeroen, Mastboom, Walter, Swank, Dingeman J., Schmitz, Roderick F., Zijsling, Bonnie, Bouvy, Nicole D., Schreinemacher, Marc H.F., van Barneveld, Kevin, Ploeg, Arianne J., Contant, C., van der Harst, Erwin, de Rooij, Peter D., Deelman, Tara, van Hout, Naomi, Stasssen, Laurents P.S., Go, Peter M.N.Y.H., Roumen, R., Simons, Maarten P., Schreurs, Hermien W.H., Keyzer-Dekker, Claudia M.G., Takkenberg, Marijn, Ugahary, Franz, Liqui Lung, Paul F., de Roos, Marnix A.J., Ong, Paul K.H., Wijffels, Rob T.M., Vierhout, Bas P., Donse, Irene F., Pierik, E.G.J.M., Buijk, Steven, Dawson, Imro, Kloppenberg, Frank, van den Broek, Rob W.F.R., van Geloven, A., Postema, Roelf R., Cate, W. Ten, Rakic, Serdjan, Schoenmaeckers, Ernst J.P., Plaisier, Peter W., Berendes, Thomas, Oostenbroek, Rob J., Poyck, Paul P.C., van Geffen, Erwin H.J.A.A., Ruurda, Jelle, Smulders, Frans J.F., Pierik, Robert E.G.J.M., Miserez, Marc, Haers, Paul, Mulier, Karel, Van den Dop, L. Matthijs, Van Egmond, Sarah, and Tanis, Pieter J.
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- 2023
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3. Race, Ethnicity, and Geography as Determinants of Excessive Weight and Low Physical Activity in Pediatric Population: Protocol for Systematic Review and Meta-Analysis.
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Statsenko, Yauhen, Smetanina, Darya, Simiyu, Gillian Lylian, Belghali, Maroua, Ghenimi, Nadirah, Mannaerts, Guido Hein Huib, Almaramah, Leena, Alhashmi, Maryam, Chun Mohammad, Nazia, Al Hamed, Rahaf, Alblooshi, Sara F., Talbi, Khawla, Albreiki, Maitha, Alkaabi, Fatima, Ponomareva, Anna, and Ljubisavljevic, Milos
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The rationale for the current study is the sparsity of data on the combined effect of the environmental and individual risks of obesity and sedentary lifestyle in children of different races/ethnicities from different regions. An effective weight management strategy is hard to design due to insufficient evidence. This work was initiated to study race, ethnicity, and geography as determinants of excessive weight and low physical activity in the pediatric population. To achieve this aim, we systematically review publications on daily length of physical activity of light, moderate, and vigorous intensity, as well as sedentary time and BMI and its dynamics in children of different races/ethnicities and geographies. The extracted data are stratified into six major geographic regions and six races/ethnicities. Then, a random-effects meta-analysis is used to calculate the pooled mean of each outcome measure. A ridge regression is constructed to explore age-related change in BMI. A Kruskal–Wallis H test is applied to compare the pooled duration of physical activity and sedentary time in the subgroups. Finally, we calculate paired correlation coefficients between BMI and physical activity/inactivity for each group. The findings can be further used in public health surveillance to clarify the epidemiology of obesity, to guide priority setting and planning, and to develop and evaluate public health policy and strategy. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Conservative management of acute appendicitis in the era of COVID 19: A multicenter prospective observational study at the United Arab Emirates
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AL Hashmi, Fatima Y., Al Zuabi, Abeer, Hachim, Ibrahim Yaseen, Mannaerts, Guido H.H., and Bekdache, Omar
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- 2021
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5. Bronchial and Systemic Inflammation in Morbidly Obese Subjects with Asthma: A Biopsy Study
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van Huisstede, Astrid, Rudolphus, Arjan, van Schadewijk, Annemarie, Cabezas, Manuel Castro, Mannaerts, Guido H. H., Taube, Christian, Hiemstra, Pieter S., and Braunstahl, Gert-Jan
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- 2014
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6. Cost-effectiveness of laparoscopic ileocaecal resection versus infliximab treatment of terminal ileitis in Crohn's disease: the LIR!C Trial
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de groof, E. Joline, Stevens, Toer W., Eshuis, Emma J., Gardenbroek, Tjibbe J., Bosmans, Judith E., van Dongen, J. M., Mol, Bregje, Buskens, Christianne J., Stokkers, Pieter C. F., Hart, Ailsa, D'Haens, Geert R., Bemelman, Willem A., Ponsioen, Cyriel Y., Warusavitarne, Janindra, van Bodegraven, Ad A., Brink, Menno A., J Consten, Esther C., van Wagensveld, Bart A., M Rijk, Marno C., P H Crolla, Rogier M., Noomen, Casper G., J Houdijk, Alexander P., Mallant, Rosalie C., Boom, Maarten, Marsman, Willem A., Stockmann, Hein B., Bruin, Karlien, Maring, John, Ditzhuijsen, Theo van, Prins, Hubert, den Brande, Jan van, Kingma, Paul, Geloven, Anna van, de Boer, Nanne, der Peet, Donald van, Jansen, Jeroen, Gerhards, Michael, van der Woude, Janneke, Schouten, Ruud, Oldenburg, Bas, van Hillegersberg, Richard, West, Rachel, Mannaerts, Guido, Spanier, Marcel, Spillenaar Bilgen, Ernst Jan, Lieverse, Rob, der Zaag, Edwin van, Depla, Annekatrien, de Laar, Arnold van, Cahen, Djuna, Health Economics and Health Technology Assessment, APH - Mental Health, APH - Methodology, APH - Health Behaviors & Chronic Diseases, AMS - Ageing and Morbidity, Surgery, Gastroenterology and hepatology, AGEM - Digestive immunity, AII - Inflammatory diseases, Amsterdam Reproduction & Development (AR&D), AGEM - Re-generation and cancer of the digestive system, Gastroenterology and Hepatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and AGEM - Endocrinology, metabolism and nutrition
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Ileocaecal resection ,Male ,Cost effectiveness ,Cost-Benefit Analysis ,Inflammatory bowel disease ,law.invention ,0302 clinical medicine ,Crohn Disease ,Randomized controlled trial ,law ,Cecum ,Colectomy ,Crohn's disease ,Infliximab/economics ,Gastroenterology ,Health Care Costs ,Ileitis ,Colectomy/economics ,Treatment Outcome ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Female ,medicine.drug ,Adult ,medicine.medical_specialty ,Terminal Ileitis ,Ileum/surgery ,Cecum/surgery ,03 medical and health sciences ,Young Adult ,Gastrointestinal Agents ,SDG 3 - Good Health and Well-being ,Ileum ,medicine ,Humans ,Gastrointestinal Agents/economics ,Laparoscopy/economics ,Retrospective Studies ,Crohn Disease/economics ,business.industry ,medicine.disease ,Infliximab ,Ileitis/diagnosis ,Surgery ,Clinical trial ,Laparoscopy ,business ,Follow-Up Studies - Abstract
ObjectiveEvaluate the cost-effectiveness of laparoscopic ileocaecal resection compared with infliximab in patients with ileocaecal Crohn’s disease failing conventional therapy.DesignA multicentre randomised controlled trial was performed in 29 centres in The Netherlands and the UK. Adult patients with Crohn’s disease of the terminal ileum who failed >3 months of conventional immunomodulators or steroids without signs of critical strictures were randomised to laparoscopic ileocaecal resection or infliximab. Outcome measures included quality-adjusted life-years (QALYs) based on the EuroQol (EQ) 5D-3L Questionnaire and the Inflammatory Bowel Disease Questionnaire (IBDQ). Costs were measured from a societal perspective. Analyses were performed according to the intention-to-treat principle. Missing cost and effect data were imputed using multiple imputation. Cost-effectiveness planes and cost-effectiveness acceptability curves were estimated to show uncertainty.ResultsIn total, 143 patients were randomised. Mean Crohn’s disease total direct healthcare costs per patient at 1 year were lower in the resection group compared with the infliximab group (mean difference €−8931; 95% CI €−12 087 to €−5097). Total societal costs in the resection group were lower than in the infliximab group, however not statistically significant (mean difference €−5729, 95% CI €−10 606 to €172). The probability of resection being cost-effective compared with infliximab was 0.96 at a willingness to pay (WTP) of €0 per QALY gained and per point improvement in IBDQ Score. This probability increased to 0.98 at a WTP of €20 000/QALY gained and 0.99 at a WTP of €500/point of improvement in IBDQ Score.ConclusionLaparoscopic ileocaecal resection is a cost-effective treatment option compared with infliximab.Clinical trial registration numberDutch Trial Registry NTR1150; EudraCT number 2007-005042-20 (closed on 14 October 2015).
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- 2019
7. The ACCURE-trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicenter trial (NTR2883) and the ACCURE-UK trial: a randomised external pilot trial (ISRCTN56523019)
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Gardenbroek, Tjibbe J., Pinkney, Thomas D., Sahami, Saloomeh, Morton, Dion G., Buskens, Christianne J., Ponsioen, Cyriel Y., Tanis, Pieter J., Löwenberg, Mark, van den Brink, Gijs R., Broeders, Ivo A. M. J., Pullens, Hendrikus J. M., Pullens, Paul H. J. M., Seerden, Tom, Boom, Maarten J., Mallant-Hent, Rosalie C., Pierik, Robert E. G. J. M., Vecht, Juda, Sosef, Meindert N., van Nunen, Annick B., van Wagensveld, Bart A., Stokkers, Pieter C. F., Gerhards, Michael F., Jansen, Jeroen M., Acherman, Yair, Depla, Annekatrien C. T. M., Mannaerts, Guido H. H., West, Rachel, Iqbal, Tariq, Pathmakanthan, Shrikanth, Howard, Rebecca, Magill, Laura, Singh, Baljit, Oo, Ye H., Htun Oo, Ye, Negpodiev, Dmitri, Dijkgraaf, Marcel G. W., D'Haens, Geert R. A. M., Bemelman, Willem A., Other departments, Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Surgery, Gastroenterology and Hepatology, AII - Amsterdam institute for Infection and Immunity, and Clinical Research Unit
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medicine.medical_specialty ,Colectomies ,business.industry ,Standard treatment ,General Medicine ,medicine.disease ,Ulcerative colitis ,Inflammatory bowel disease ,Surgery ,law.invention ,Clinical trial ,Study Protocol ,Randomized controlled trial ,law ,Multicenter trial ,Medicine ,Appendectomy ,Disease course ,business ,Prospective cohort study - Abstract
Background: Over the past 20 years evidence has accumulated confirming the immunomodulatory role of the appendix in ulcerative colitis (UC). This led to the idea that appendectomy might alter the clinical course of established UC. The objective of this body of research is to evaluate the short-term and medium-term efficacy of appendectomy to maintain remission in patients with UC, and to establish the acceptability and cost-effectiveness of the intervention compared to standard treatment. Methods/Design: These paired phase III multicenter prospective randomised studies will include patients over 18 years of age with an established diagnosis of ulcerative colitis and a disease relapse within 12 months prior to randomisation. Patients need to have been medically treated until complete clinical (Mayo score
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- 2015
8. Treatment of giant hiatal hernia by laparoscopic Roux-en-Y gastric bypass
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Duinhouwer, Lucia E., Biter, L. Ulas, Wijnhoven, Bas P., and Mannaerts, Guido H.
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- 2015
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9. The Sleeve Bypass Trial: a multicentre randomized controlled trial comparing the long term outcome of laparoscopic sleeve gastrectomy and gastric bypass for morbid obesity in terms of excess BMI loss percentage and quality of life.
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Biter, L. Ulas, Gadiot, Ralph P. M., Grotenhuis, Brechtje A., Dunkelgrün, Martin, van Mil, Stefanie R., Zengerink, Hans J. J., Smulders, J. Frans, and Mannaerts, Guido H. H.
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BARIATRIC surgery ,GASTRIC bypass ,OVERWEIGHT persons ,RANDOMIZED controlled trials ,QUALITY of life ,COMORBIDITY ,LAPAROSCOPIC surgery - Abstract
Background: Obesity is an increasing disease worldwide. Bariatric surgery is the only effective therapy to induce sufficient long-term weight loss for morbidly obese patients. Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is the gold standard surgical technique. Laparoscopic Sleeve Gastrectomy (LSG) is a new promising bariatric procedure which has the advantage of maintaining an intact gastrointestinal tract. The aim of this study is to evaluate the efficiency of both techniques. Our hypothesis is that LSG has a similar percentage excess BMI loss (%EBMIL) after 5 years compared to LRYGB. Methods/Design: The Sleeve Bypass Trial is a randomized multicentre clinical trial: patients eligible for bariatric surgery are randomized to either LSG or LRYGB. Patients with a body mass index (BMI) = 40 kg/m² or BMI 35 kg/m² with obesity related comorbidity (T2 DM, sleep apnoea, hypertension) are eligible for randomization. At randomization patients are stratified for centre, sex, T2 DM and BMI ≥ = 50 kg/m². A total number of 620 patients will be enrolled and equally (1:1) randomized to both treatment arms. Only surgeons experienced in both operation techniques will participate in the Sleeve Bypass trial. The primary endpoint is the 5-year weight loss (%EBMIL) of LSG and LRYGB. Secondary endpoints are resolution of obesity related comorbidity, complications, revision bariatric surgery and quality of life (QOL) defined in various questionnaires. Discussion: Long-term %EBMIL between the two treatment strategies used to be in favour of LRYGB, but more recent results throughout the world show similar %EBMIL in both techniques. If weight loss is comparable, obesity-related comorbidity and QOL after bariatric procedures should be taken into account when deciding on which surgical technique is to be preferred for certain subgroups in the future. Trial registration: Dutch Trial Register: NTR 4741. [ABSTRACT FROM AUTHOR]
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- 2015
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10. Study protocol of the DUCATI-study: a randomized controlled trial investigating the optimal common channel length in laparoscopic gastric bypass for morbid obese patients.
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Gadiot, Ralph P. M., Grotenhuis, Brechtje A., Biter, L. Ulas, Dunkelgrun, Martin, Zengerink, Hans J. J., Feskens, Pierre B. G. M., and Mannaerts, Guido H. H.
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OBESITY treatment ,PREVENTION of obesity ,WEIGHT loss -- Social aspects ,OVERWEIGHT persons ,MALNUTRITION ,MANAGEMENT ,HEALTH - Abstract
Background: Morbid obesity has become one of the most frequent chronic medical disorders in Western countries, affecting 1.5-2 % of the Dutch population. Currently, the laparoscopic Roux-Y gastric bypass is considered to be the most effective bariatric treatment option for morbid obesity as it results in adequate weight loss and a significant decrease in comorbidity. Although this technique has been applied for years, the optimal lengths of the three bowel limbs (alimentary limb, biliopancreatic limb, and common channel) in order to achieve maximal percentage excess weight loss with minimal side effects (i.e. malabsorption symptoms), are unknown. As 'normal'' sized gastric bypasses achieve an average of 60 - 80 % excess weight loss after one year, one could hypothesize that afferent limb lengths should be longer in order to reduce the common channel length, thereby improving outcome in terms of excess weight loss. The aim of the current study is to investigate the effect of the length of the common channel in gastric bypass surgery for morbid obesity. In this randomized controlled trial the very long Roux limb gastric bypass will be compared to the standard gastric bypass, in order to conclude which option is the optimal therapeutic strategy in the morbidly obese patient. Methods/design: In this multicentre trial patients will be randomized either to a very long Roux limb gastric bypass with a fixed common channel length of 100 cm, or to a standard gastric bypass with a variable common channel length. The primary objective is to evaluate whether the very long Roux limb gastric bypass is superior in terms of percentage excess weight loss after one year follow-up compared to the standard gastric bypass. Secondary endpoints are quality-of-life, cure /improvement of obesity related comorbidity, complications, malnutrition, re-admission rate, and re-operation rate. Discussion: We hypothesize that our proposed distal LRYGB will provide for improved results concerning % EWL with an acceptable rate of (metabolic) complications. Our main point of interest is to determine if the distal LRYGB is a superior alternative to standard LRYGB in terms of percentage excess weight loss and to put more focus on the role of the common channel. Therefore we will perform this randomized controlled trial comparing both techniques, with % EWL as a primary outcome. [ABSTRACT FROM AUTHOR]
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- 2015
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11. Metabolomic Profiling of Lipids and Fatty Acids: 3 Years Postoperative Laparoscopic Sleeve Gastrectomy.
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Sharma, Charu, Platat, Carine, Gariballa, Salah, Muhairi, Shamma Jauaan Al, Aidaros, Anas Al, Mannaerts, Guido Hein Huib, Al Afari, Hamouda Salim, Yasin, Javed, Y. Al-Dirbashi, Osama, and Alkaabi, Juma
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SLEEVE gastrectomy ,FATTY acids ,BARIATRIC surgery ,OPERATIVE surgery ,BLOOD lipids - Abstract
Simple Summary: Laparoscopic Sleeve Gastrectomy (LSG) is one of the most effective type of bariatric surgery for weight loss that enables reduction in the size of stomach and associated comorbidities arises from obesity. LSG is well-accepted and safe surgical procedure, but it may lead to malabsorption of nutrients. However, long-term impact of LSG on other risk factors, including blood lipid and fatty acid (FA) profiles, largely remains unknown. The present study aimed to investigate the lipid and plasma FA profiles in patients who underwent LSG in reference to control group with obesity. We determine the markers of inflammation and metabolic risk in these groups by measuring different saturated, monounsaturated, polyunsaturated, and medium-chain FAs. We also estimated the activity of enzymes involved in synthesis of endogenous FA using the product precursor ratios of individual FAs as markers of global metabolic risk. Our study findings showed that patient's 3-yrs post LSG developed a favorable lipid profile than control with similar metabolic profile in both groups, as determined by the blood FA profile and FA ratios. Our findings showed that LSG offers extended positive effect on the lipid profile in obese population. Though, lifestyle interventions following strict regular follow-up to maintain general health and well-being. Visceral obesity is common in the United Arab Emirates and worldwide. Although laparoscopic sleeve gastrectomy (LSG) leads to effective and sustainable weight loss, its long-term beneficial impact on other risk factors, including blood lipid and fatty acid (FA) profiles, remains unknown. These two profiles were assessed in patients 3 years after undergoing LSG and in LSG candidates (controls). Lipid profiles were measured using the Cobas e411 modular analyzer, and 35 FAs were identified. The age and body mass index were 36.55 ± 8.65 years and 31.49 ± 6.43 kg/m
2 in the LSG group and 35.44 ± 9.51 years and 32.29 ± 5.38 kg/m2 in the control group, respectively. The overall lipid profile was more favorable in the LSG group than in the control group. Total saturated, monounsaturated, and polyunsaturated FAs were similar between the groups, but total medium-chain FAs were more abundant in the LSG group. In endogenous FA synthesis, the estimated activity of C16Δ9 desaturase and Δ5 desaturase decreased, whereas that of elongase increased in the LSG group compared with that in the control group. The benefits of LSG on blood lipid and FA profiles in patients with 3-year LSG may be limited. Hence, lifestyle interventions combined with a long-term and strict regular follow-up regime may be warranted for patients undergoing LSG. [ABSTRACT FROM AUTHOR]- Published
- 2021
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12. Deep Learning-Based Automatic Assessment of Lung Impairment in COVID-19 Pneumonia: Predicting Markers of Hypoxia With Computer Vision.
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Statsenko Y, Habuza T, Talako T, Pazniak M, Likhorad E, Pazniak A, Beliakouski P, Gelovani JG, Gorkom KN, Almansoori TM, Al Zahmi F, Qandil DS, Zaki N, Elyassami S, Ponomareva A, Loney T, Naidoo N, Mannaerts GHH, Al Koteesh J, Ljubisavljevic MR, and Das KM
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Background: Hypoxia is a potentially life-threatening condition that can be seen in pneumonia patients., Objective: We aimed to develop and test an automatic assessment of lung impairment in COVID-19 associated pneumonia with machine learning regression models that predict markers of respiratory and cardiovascular functioning from radiograms and lung CT., Materials and Methods: We enrolled a total of 605 COVID-19 cases admitted to Al Ain Hospital from 24 February to 1 July 2020 into the study. The inclusion criteria were as follows: age ≥ 18 years; inpatient admission; PCR positive for SARS-CoV-2; lung CT available at PACS. We designed a CNN-based regression model to predict systemic oxygenation markers from lung CT and 2D diagnostic images of the chest. The 2D images generated by averaging CT scans were analogous to the frontal and lateral view radiograms. The functional (heart and breath rate, blood pressure) and biochemical findings (SpO
2 , H C O 3 - , K+ , Na+ , anion gap, C-reactive protein) served as ground truth., Results: Radiologic findings in the lungs of COVID-19 patients provide reliable assessments of functional status with clinical utility. If fed to ML models, the sagittal view radiograms reflect dyspnea more accurately than the coronal view radiograms due to the smaller size and the lower model complexity. Mean absolute error of the models trained on single-projection radiograms was approximately 11÷12% and it dropped by 0.5÷1% if both projections were used (11.97 ± 9.23 vs. 11.43 ± 7.51%; p = 0.70). Thus, the ML regression models based on 2D images acquired in multiple planes had slightly better performance. The data blending approach was as efficient as the voting regression technique: 10.90 ± 6.72 vs. 11.96 ± 8.30%, p = 0.94. The models trained on 3D images were more accurate than those on 2D: 8.27 ± 4.13 and 11.75 ± 8.26%, p = 0.14 before lung extraction; 10.66 ± 5.83 and 7.94 ± 4.13%, p = 0.18 after the extraction. The lung extraction boosts 3D model performance unsubstantially (from 8.27 ± 4.13 to 7.94 ± 4.13%; p = 0.82). However, none of the differences between 3D and 2D were statistically significant., Conclusion: The constructed ML algorithms can serve as models of structure-function association and pathophysiologic changes in COVID-19. The algorithms can improve risk evaluation and disease management especially after oxygen therapy that changes functional findings. Thus, the structural assessment of acute lung injury speaks of disease severity., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Statsenko, Habuza, Talako, Pazniak, Likhorad, Pazniak, Beliakouski, Gelovani, Gorkom, Almansoori, Al Zahmi, Qandil, Zaki, Elyassami, Ponomareva, Loney, Naidoo, Mannaerts, Al Koteesh, Ljubisavljevic and Das.)- Published
- 2022
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13. Erratum to: The ACCURE-trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicenter trial (NTR2883) and the ACCURE-UK trial: a randomised external pilot trial (ISRCTN56523019).
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Gardenbroek TJ, Pinkney TD, Sahami S, Morton DG, Buskens CJ, Ponsioen CY, Tanis PJ, Löwenberg M, van den Brink GR, Broeders IA, Pullens HJ, Seerden T, Boom MJ, Mallant-Hent RC, Pierik RE, Vecht J, Sosef MN, van Nunen AB, van Wagensveld BA, Stokkers PC, Gerhards MF, Jansen JM, Acherman Y, Depla AC, Mannaerts GH, West R, Iqbal T, Pathmakanthan S, Howard R, Magill L, Singh B, Oo YH, Negpodiev D, Dijkgraaf MG, D'Haens GR, and Bemelman WA
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- 2016
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