Pfizer Inc., New York, NY Dainippon Sumitomo Pharma, Tokyo, Japan Innovative Med Concepts LLC (IMC), Tuscaloosa, AL Ironwood Pharmaceuticals, Cambridge, MA Purdue Pharma, Stamford, CT Shire, Lexington, MA Theravance Biopharma, South San Francisco, CA Toray, Tokyo, Japan Eli Lilly and Company, Indianapolis, IN Forest Laboratories, New York, NY Tonix Pharmaceuticals, New York, NY Cerephex Corporation, Los Altos, CA National Institutes of Health, Bethesda, MD National Institutes of Health Grunenthal, Aachen Germany Orion Pharma, Espoo, Finland This manuscript, developed by a group of chronic pain researchers and clinicians from around the world, aims to address the state of knowledge about fibromyalgia (FM) and identify ongoing challenges in the field of FM and other chronic pain syndromes that may be characterized by pain centralization/amplification/hypersensitivity. There have been many exciting developments in research studies of the pathophysiology and treatment of FM and related syndromes that have the potential to improve the recognition and management of patients with FM and other conditions with FM-like pain. However, much of the new information has not reached all clinicians, especially primary care clinicians, who have the greatest potential to use this new knowledge to positively impact their patients' lives. Furthermore, there are persistent misconceptions about FM and a lack of consensus regarding the diagnosis and treatment of FM. This paper presents a framework for future global efforts to improve the understanding and treatment of FM and other associated chronic pain syndromes, disseminate research findings, identify ways to enhance advocacy for these patients, and improve global efforts to collaborate and reach consensus about key issues related to FM and chronic pain in general. Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA Cardiff Inst Infect & Immun, Cardiff, S Glam, Wales Univ Michigan, Ann Arbor, MI 48109 USA Tufts Univ, Sch Med, Boston, MA 02111 USA Univ Fed Sao Paulo, Sao Paulo, Brazil Aarhus Univ, Danish Pain Res Ctr, Aarhus, Denmark Hyogo Coll Med, Nishinomiya, Hyogo, Japan Aichi Med Univ, Multidisciplinary Pain Ctr, Nagakute, Aichi, Japan Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA China Japan Friendship Hosp, Beijing, Peoples R China Univ Fed Sao Paulo, EPM, Sao Paulo, Brazil Web of Science