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Climate change has substantial impacts on regional hydrology in the major river basins. To figure out such latent hydrological impacts of changing climate, more reliable hydrological simulations are imperative. In this study, we evaluated the impacts of climate change on hydrological regime in the Upper Yangtze River Basin based on four downscaled and bias-corrected Global Climate Model outputs from Coupled Model Intercomparison Project Phase 5 under four Representative Concentration Pathways (RCP2.6, RCP4.5, RCP6.0, and RCP8.5) driving three hydrological models. Two model evaluation approaches were applied: simple and comprehensive. The comprehensive approach was used to evaluate models in the historical period, optimizing objective function at four gauges, and hydrological models were weighted for impact assessment based on their performance. In such a way, projected streamflow time series are obtained under different emission scenarios. Results show that the annual average discharge is projected to increase by 4.1–10.5% under the RCP scenarios at the end of twenty-first century relative to the reference period (1970–1999). Moreover, the high flow is projected to increase and the low flow to decrease indicating a higher probability of flood and drought occurrence in the basin. The severity of floods and droughts may increase. In comparison with the simple one-site model evaluation approach, the comprehensive method reveals that the anticipated extreme flow events would be less severe, and annual mean discharge slightly lower. The projected results imply that application of the comprehensive model evaluation approach could narrow the simulated spreads of projections significantly, and might provide more credible results. [ABSTRACT FROM AUTHOR]