1. Hematopoietic Cell Transplantation for Systemic Sclerosis—A Review.
- Author
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Levin, Daniel, Osman, Mohammed S., Durand, Caylib, Kim, Hyein, Hemmati, Iman, Jamani, Kareem, Howlett, Jonathan G., Johannson, Kerri A., Weatherald, Jason, Woo, Matthew, Lee, Jason, and Storek, Jan
- Subjects
HEMATOPOIETIC stem cell transplantation ,SYSTEMIC scleroderma ,CONNECTIVE tissue diseases ,KNOWLEDGE gap theory - Abstract
Systemic sclerosis (SSc) is an autoimmune, multi-organ, connective tissue disease associated with significant morbidity and mortality. Conventional immunosuppressive therapies demonstrate limited efficacy. Autologous hematopoietic stem cell transplantation (HCT) is more efficacious but carries associated risks, including treatment-related mortality. Here, we review HCT as a treatment for SSc, its efficacy and toxicity in comparison to conventional therapies, and the proposed mechanisms of action. Furthermore, we discuss the importance of and recent developments in patient selection. Finally, we highlight the knowledge gaps and future work required to further improve patient outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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