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Four previously unreported diterpenoids including three ent -atisanes (1–3) and one ent -abietane (4), along with one known linear triterpenoid (5) and five known diterpenoids including four myrsinanes (6–9), and one abietane (10) have been isolated from the roots of Euphorbia spinidens Bornm. ex Prokh. The structures were determined on the basis of extensive spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR and comparison of the data with those reported in the literature. Antimicrobial potential of isolated compounds were also evaluated. Guionianol B (10) showed good antibacterial activity against Staphylococcus aureus and Bacillus subtilis with MIC value of 6.25 μg/mL. [Display omitted] [ABSTRACT FROM AUTHOR]

Three undescribed compounds (1 – 3), including two butenolides and one indol alkaloids. Together with twenty-one known compounds (4 – 24) were isolated and identified from Lepidium obtusum Basin. Their structures were elucidated by spectroscopic analysis and ECD calculations. The isolated compounds were tested for their antimicrobial, antioxidant, and anti-inflammatory activities. Among them, compounds 11 , 12 , 14 , 21 and 23 showed moderated antimicrobial activities against (Candida albicans , E. coli , Staphylococcus aureus). Compounds 11 , 12 , 14 , 15 , 17 and 18 exhibited potent antioxidant activities against ABTS and DPPH. Compound 1 exhibited moderated anti-inflammatory activities. Compounds 4 – 24 were isolated from this plant for the first time. [Display omitted] [ABSTRACT FROM AUTHOR]

Two altenuene derivatives ( 1 – 2 ) and one isocoumarin ( 3 ), together with six known compounds ( 4 – 9 ) were isolated from solid cultures of an endophytic fungus Alternaria alternata , obtained from the fresh branches of Camellia sinensis . Chiral analysis revealed the racemic nature of 1 and 2 , which were subsequently resolved into two pairs of enantiomers [(+)- 1 and (−)- 1 , (+)- 2 and (−)- 2 ]. Structures of all the isolates were identified through spectroscopic data. Absolute configurations of the two pairs of enantiomers were determined by electronic circular dichroism (ECD) calculation and the chiral center of C-10 in 3 was deduced via [Rh 2 (OCOCF 3 ) 4 ]-induced CD experiment. All the isolates were evaluated for their antimicrobial abilities against the pathogenic bacteria and fungi as well as cytotoxic activities against two human tumor cell lines. Compound 5 was the most active against Bacillus subtilis with MIC 80 of 8.6 μ g/ml, and compounds 1 – 3 , 6 – 7 and 9 exhibited moderate to weak inhibition towards the test pathogenic microorganism. Compound 4 showed mild cytotoxic activity against human osteosarcoma cells U2OS with IC 50 of 28.3 μ M. [ABSTRACT FROM AUTHOR]

Fourteen new compounds including thirteen drimane – phthalide derivatives (fendlerals A – C, fendlerins A – D, fendlerols A – B, fendleric acids A – C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C – D, fendleryls C – D, atromentin, tetramethyl atromentin, and (±)-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane – phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1–3 exhibited antimicrobial activity against Plasmodium falciparum (IC 50 4.15–4.39 μM), Colletotrichum capsici (MIC 6.25–12.5 μg/mL), and Bacillus cereus (MIC 1.56–3.13 μg/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells. Unlabelled Image [ABSTRACT FROM AUTHOR]