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Entomopathogenic fungi are economically important fungi from environmental, agricultural, and human health perspectives. They are an alternative to chemical pesticides. They can also be used as biostimulants and biological control agents for mosquitoes and other insects. These fungi are also known to produce a variety of metabolites of industrial significance. They face challenges in the cultivation, fermentation, and purification of products. Their habitats and ecological niches are of special significance for ex situ conservation and the large scale of production of spores.This book reviews molecular aspects of the pathogenesis of entomopathogenic fungi, the development of mycoinsecticides, and its regulatory aspects. It addresses different aspects of entomopathogenic fungi, including host-pathogen interactions (susceptibility and resistance), fungus-insect and fungus-fungus dual interactions, phylogeny and taxonomy, biochemistry, and molecular basis of enteropathogenesis, market potential of entomopathogens, regulatory aspects, bioprospecting of fungi, fungi as crop bodyguards and in disease suppression, and consortia for the control of insect pests and pathogens in single crop systems.

Molecular and Cell Biology of the Liver features the latest research findings regarding liver structure and function. A unique feature of the book is the brief science reviews that are included in each chapter which provide essential background information to allow readers to better grasp the subject matter within a chapter. The book covers liver biology from the molecular level to groups of liver cells and explains how groups of hepatocytes interact in similar microenvironments. Other important cell types found in the liver are also examined. Illustrations ranging from electron micrographs to fully rendered drawings act as visual aids to help readers understand complex structural-functional interactions. Molecular and Cell Biology of the Liver will benefit hepatologists, gastroenterologists, cell biologists, anatomists, toxicologists, and other researchers interested in liver structure and function.

This book brings together the molecular aspects of the pathogenesis of entomopathogenic fungi, various aspects of mycoinsecticide development, and regulatory aspects to highlight the immense contribution of the agricultural sector. The chapters address aspects of entomopathogenic fungi, including host-pathogen interactions (susceptibility and resistance), fungus-insect and fungus-fungus dual interactions, phylogeny and taxonomy, biochemistry, and molecular basis of enteropathogenesis, market potential of entomopathogens, regulatory aspects, bioprospecting of fungi, fungi as crop bodyguards and in disease suppression, and consortia for the control of insect pests and pathogens in single crop systems. Written by experts in academia and industry from Algeria, Brazil, Hungary, India, Italy, Malaysia, Oman, Pakistan, and the United States, the book overviews entomopathogenic fungi used as biological control agents against insect pests and other arthropods, their mode of action, pathogenesis, bioactive metabolites, mycotoxins involved, their mass production, limitations, and agricultural- and environment-related issues. It also includes developing various biopesticide products, with special references to formulations and prospects. In agriculture, crop protection and production depend on insect pests controlled by entomopathogenic fungi. Understanding the pathogenicity, mechanism of action, formulations, and applications of a wide array of entomopathogenic fungi as biopesticides is a valid eco-friendly approach. The book provides advances in pathogenicity, biochemistry, virulence, and interaction that facilitate the application of Beauveria, Metarhizium, and other entomopathogens as potential biopesticides against major insect pests. Developments in bioactive compounds, secondary metabolites, enzymes, and toxins of entomopathogenic fungi have facilitated precise applications and management to target insect pests. Further advances in molecular aspects, the formulation of nanobiopesticides, and biofabricated technology paved the way for insect pest control. This book will be a helpful resource for students, teachers, researchers, scientists, and professionals in the industry working on biological sciences, applied entomology, mycology, zoology, forestry, biochemistry, molecular biology, and nanotechnology.

The Tata Memorial Centre Textbook of Oncology is an authoritative and comprehensive book, meticulously compiled to cover contemporary issues in oncology. It features contributions from 189 authors, culminating in 76 chapters. Authored by faculty members from the renowned Tata Memorial Centre, this textbook offers a harmonious blend of detailed information and practical approaches. It serves as a comprehensive resource that contextualizes the practice of oncology in TMC and offers insights into delivering high-quality cancer care in diverse settings. It offers an authentic overview of the TMC approach to multidisciplinary cancer care. The Textbook is designed to cater to a wide array of readers – from undergraduate medical students to postgraduates specializing in general surgery, general medicine, pediatrics, gynecology, radiation oncology, and other disciplines, and practicing community oncologists. A notable feature of the Textbook is its utility in preparing students for entrance and exit examinations. This book is an essential resource for established cancer specialists, including surgeons, medical oncologists, radiation oncologists, and those in allied fields. It is also invaluable for super-specialty students and postgraduates with an interest in cancer management, offering a comprehensive guide to the dynamic field of oncology.

Derived from the renowned multi-volume International Encyclopaedia of Laws, this very useful analysis of constitutional law in Italy provides essential information on the country's sources of constitutional law, its form of government, and its administrative structure. Lawyers who handle transnational matters will appreciate the clarifications of particular terminology and its application. Throughout the book, the treatment emphasizes the specific points at which constitutional law affects the interpretation of legal rules and procedure. Thorough coverage by a local expert fully describes the political system, the historical background, the role of treaties, legislation, jurisprudence, and administrative regulations. The discussion of the form and structure of government outlines its legal status, the jurisdiction and workings of the central state organs, the subdivisions of the state, its decentralized authorities, and concepts of citizenship. Special issues include the legal position of aliens, foreign relations, taxing and spending powers, emergency laws, the power of the military, and the constitutional relationship between church and state. Details are presented in such a way that readers who are unfamiliar with specific terms and concepts in varying contexts will fully grasp their meaning and significance. Its succinct yet scholarly nature, as well as the practical quality of the information it provides, make this book a valuable time-saving tool for both practising and academic jurists. Lawyers representing parties with interests in Italy will welcome this guide, and academics and researchers will appreciate its value in the study of comparative constitutional law.

This book provides a comprehensive overview of recent advances in nanotechnology as an alternative strategy for addressing antimicrobial resistance (AMR). Examining nanotechnology-based methods such as nanoencapsulation, drug delivery, and conjugation, the text highlights their successful application in treating microbial infections with reduced resistance and off-target toxicity. The introductory section outlines AMR and explores diverse mechanisms of microbial resistance, emphasizing the potential of nanotechnology to surmount these challenges. Subsequent chapters investigate the role of specific nanomaterials—metal nanoparticles, metal oxide nanoparticles, functionalized quantum dots, magnetic nanoparticles, bimetallic nanoparticles, nanocomposites, carbon nanomaterials, and polymer-based nanomaterials—in overcoming antimicrobial resistance. Several chapters focus on the efficacy of nanoemulsions as an antimicrobial delivery method, underscoring their inherent antimicrobial properties, capacity to enhance drug solubility, stability, bioavailability, and targeting potential at the organ and cellular levels. The concluding section provides a detailed review of liposomes, dendrimers-based nanoparticles, and micelles as drug delivery vehicles in the context of combating pathogens resistant to antimicrobials.

This book provides the latest information on trans-Himalayan Hindu Kush Region (HKR) fisheries including the Indian Himalayan Region (IHR) as well as the historical context of its sustainable development for improving livelihood and nutritional security. The book serves as an important document to provide knowledge and information about the major concerns of environmental and anthropogenic factors that have impacted the population of certain important fishes in the ecosystem and the strategies and policies required for the conservation of these important groups of fishes, viz., Mahseer, snow trout, minor carp, catfishes, etc. The chapters describe the information to the readers on potential cold water and cool water fish species suitable for large-scale farming and propagation addressing the issues of diseases, nutrigenomics, and nanobiotechnology. This book also addresses the prospects and potential of recreational fishing in India and the scope for its improvement to generate more employment and income citing the success stories and primary information from reputed anglers. Finally, the book also elucidates a comprehensive yet representative description of many challenges associated with inland coldwater- cool water fisheries and aquaculture in HKR, IHR, and its way forward.

Engineers have long been architects of progress, erecting massive buildings that touch the skies and designing technologies that redefine realms of known possibility. In this era of rapid change, keeping pace with innovation is the main challenge. Emerging Engineering Technologies and Industrial Applications is a comprehensive research book that delves deep into the heart of a relentless technological revolution within modern industry. From the limitless potential of the Internet of Things (IoT) to the cognitive wonders of Artificial Intelligence (AI), from the microscopic marvels of Nanotechnology to the precision and agility of Robotics, and from the revolutionary advancements in 3D Printing to the transformative capabilities of blockchain, this book explores emerging technologies. This book equips industrial and research engineers, alongside research scientists, with the tools needed to stay relevant and at the forefront of their industries. It offers valuable insights into harnessing these technologies to improve product design development processes and contribute significantly to their respective fields'growth. The book underscores the urgency to adopt the new technologies, emphasizing that industries or companies which fail to integrate these technologies risk becoming relics of the past. Topics span a broad spectrum, including the pivotal overview of emerging technologies in engineering, AI's transformative applications, the agility and precision of Robotics, the interconnected world of IoT, the infinitesimal marvels of Nanotechnology, and the future trajectories of these technological juggernauts. This book is an indispensable resource for professionals and researchers working in the field of emerging engineering technologies and their industrial applications. It caters to a diverse range of disciplines, including computer science and information technology, environmental, agricultural, and physical sciences, medical, healthcare, and life sciences, as well as science and engineering, and anyone seeking to navigate the current technological progress in the 21st century.

Antimicrobial peptides (AMPs) have been sought to be a potential alternative to the current arsenal of antibiotics against undesirable microbes. AMPs synthesized by lactic acid bacteria have attracted significant attention due to their strong activity against a broad range of bacteria including pathogens. The bacteriocin (an AMP) has been known to us since early 1928, a year before penicillin was reported. This is possibly due to their narrower activity compared to antibiotics. However, several AMPs having promising activity have been thoroughly characterized in the past few decades. Renewed interest has developed focusing on industrially important bacteriocins produced by lactic acid bacteria. Some of these AMPs are also active against food spoilage and clinically important pathogens. Similar to antibiotics, large-scale intellectual screening is ongoing in the search for novel AMPs with unique properties. Recent research has revealed that AMPs may also play a role in maintaining gut microflora and keeping us protected from food-borne pathogens. The ongoing genomic studies suggest that there may be more such bioactive compounds waiting to be explored. This book provides an overview of the fundamental knowledge accumulated so far regarding the diversity and potential applications of AMPs produced by lactic acid bacteria. This updated reference book on AMPs from lactic acid bacteria is timely, covering the most important achievements in the field and providing the scientific community particularly graduate students, researchers, and clinicians with the latest updates. The goal of this book is to illustrate and detail the findings made so far, debate the state of the art, and draw new perspectives.

This compilation, The Making and Ending of Federalism, includes the main topics addressed by recognized experts on federalism at the Conference of the International Association of Federal Studies (IACFS) held in Innsbruck, Austria, on 28-30 October 2021. It analyzes how federal and quasi-federal systems are created and if there are common patterns or certain conditions that promote the emergence or the demise of federal systems, including case studies from Brazil, Spain, and Italy.

In this book, internationally recognised experts provide an update on some important basic and technical aspects of neurosurgery. Intracranial tumours are the main focus of the book with chapters dealing with ependymomas, a tumour that still offers difficulties of interpretation in terms of both pathological features and management modalities, intraventricular tumours, which require particular attention in the choice of treatment modalities, and tumours considered typically paediatric that may still present in adulthood although with different aspects. Technical approaches to difficult anatomical areas are discussed in three chapters, dealing with the orbit, the craniocervical junction and the brainstem, respectively. Two rather didactic chapters, dealing with the minimally invasive technique for the spine and the clipping of cerebral aneurysms, are intended to contribute to the training of young neurosurgeons by illustrating the surgical steps in detail. The contribution of ultrasound to neurosurgery is illustrated in two chapters that should arouse great interest. The so-called Chiari malformations is approached in a chapter emphasising the role of cranio-cerebral disproportion in their pathogenesis. Finally, a chapter devoted to the ethical attitude that should characterise the daily practice of the neurosurgeon completes the book.Like the previous volumes in the series, this one represents an important contribution to the advancement of neurosurgical specialities.

The gold standard in gastrointestinal pathology textbooks returns More than 34 million Americans suffer from pathologies of the digestive system, with over 20 million of these disorders chronic. Treatment of these patients is a complex multidisciplinary area of clinical medicine, drawing upon expertise not only from specialist gastroenterologists but also pathologists, immunologists, endoscopists, and more. Morson & Dawson's Gastrointestinal Pathology has long set the standard for pathology textbooks, with its distinctive balance of clinical gastroenterology and pathology. Now fully updated to reflect the latest research in this vital field of medicine, it promises to bring this subject to a new generation of clinicians and pathologists worldwide. Readers of the sixth edition of Morson and Dawson's Gastrointestinal Pathology will also find: Contemporary recommendations and guidelines for getting the most out of every pathology specimen and producing the best possible report for managing the patientDiscussions of the evolving applications of immunohistochemistry and in situ hybridisationA completely new chapter on lymphoid and other tumours of the large intestine Morson & Dawson's Gastrointestinal Pathology is ideal for gastrointestinal pathologists, general pathologists, gastroenterologists, and any clinicians who work with or in gastrointestinal practice.

This fourth edition offers a practical guide to endovascular treatment of cerebrovascular disease and provides a comprehensive reference for the related neurovascular anatomy and the various disorders that affect the vascular system. Chapters cover fundamental principles underlying cerebral and spinal angiography; interventional techniques, devices, and practice guidelines; and commonly encountered cerebrovascular disorders for which interventional and endovascular methods are appropriateBuilding on the previous edition, the text is presented similarly in style and scope to emphasize accessibility and ease of reading. All chapters are fully updated to include more recent data, and obsolete products and techniques are replaced with the most current technology. Some key updates include:A greater emphasis on the use of radial artery access for the discussed endovascular techniques.The associations of COVID-19 with ischemic stroke and the implicationsof providing care for cerebrovascular patients during a pandemic.An extensive update to the acute ischemic stroke chapter with new references and format to more closely follow the format of other chapters in that section.Expansion of the pediatric sections of disease chapters, including discussions of genetic associations with disease. This is an ideal guide for clinicians and trainees in neurology, neurosurgery and neuroradiology, as well as practicing clinicians in related fields caring for patients with cerebrovascular disease.

Genetics and Epigenetics of Genitourinary Diseases aims to provide a comprehensive collection of data on genetics and epigenetics in almost all genitourinary diseases for researchers, clinicians, and graduate students. This book discusses several genetic and epigenetic changes like DNA methylation, mutations, single nucleotide polymorphisms, DNA rearrangements, chromosomal remodeling, microsatellite instability, and chromosomal instability (CIN) in genitourinary cancers. This book is split into 18 chapters, beginning with the importance of genetics and epigenetics in genitourinary diseases. It then goes on to cover the genetics and epigenetics of various diseases and tumors. Certain chapters present novel techniques of next-generation sequencing (NGS). Furthermore, RNA-Seq is discussed as a sequencing technique that uses NGS to reveal the presence and quantity of RNA in a biological sample. This book is a valuable resource for researchers, practitioners, and students in genetics and epigenetics who want to broaden their understanding of the field. - Provides a unique collection of genetics and epigenetics in genitourinary - Covers the subject of genetic and epigenetics in urological malignancies, infertility, and urolithiasis - Gives novel insights into genitourinary diseases even the rare ones and sheds light on genitourinary diseases from DNA methylation to CIN

Evolving Landscape of Molecular Diagnostics: Applications and Techniques presents cutting-edge reviews on current and emerging technologies in the diagnosis of microbial infections. The book discusses the fundamentals of Molecular Diagnostics for bacteria, fungi, viruses and a variety of state-of-the-art diagnostics tools and techniques for obtaining qualitative and quantitative results. It includes topics such as Next generation sequencing and application of'OMICS'for early disease diagnosis. Sections cover the entire spectrum of emerging diagnostic tools and techniques, as well as the principles, pros and cons of each method and applications for diagnosis of infectious disease in plants, humans and veterinary. This is a resource for both researchers and students working in clinical microbiology, infectious biology, applied life sciences and scientists working in the clinical diagnostic industry. - Provides a wide range of diagnostics tools and technologies in the field of infectious biology - Presents discussions on emerging technologies for early disease diagnosis and novel diagnostics techniques for detection of COVID, Urea Breath Tests for Detection of Helicobacter pylori, Loop-Mediated Isothermal Amplification as Point-of-Care Diagnosis, Molecular imaging, Lab-on-a-chip Technologies, and several others - Analyzes literature reviews, underpinning methodologies, and opportunities and limitations - Includes case studies and examples that highlight applications using the underpinning techniques

This volume 2 of a two-volume work provides an overview of the current state of knowledge on the most common viral and parasitic diseases in turkeys. Each chapter is dedicated to a specific infectious disease and provides information on pathogenesis, symptoms and therapeutic strategies. The book also addresses nutritional diseases in fattening turkeys, and introduces diagnostic techniques as well as disease prevention and control strategies. The clear and structured layout allows the reader to refer to it quickly. This book is an indispensable guide for veterinarians, researchers and professionals working in turkey production and health.

This book covers all diagnostic and therapeutic aspects of neuro-oncological diseases. In the last decade, the management of brain tumors has been revolutionized following the new WHO classification and thanks to the introduction of molecular markers into the clinical routine. From an imaging point of view, the continuous technological developments and the implementation of various radiopharmaceuticals have paved the way to new clinical indications and has helped optimize patient management. In this context, a major breakthrough could derive from the introduction of radiomics and artificial intelligence in the diagnostic and therapeutic pathway. Not forgetting the emerging role of heavy-ion therapy as a complement to the innovative drugs and treatments adopted in medical oncology and radiation therapy. In the present book, all above-mentioned aspects are covered, starting with the novel standards for the WHO classification of brain tumors, to the up-to-date surgical techniques and advanced therapeutic approaches, passing through the currently available imaging modalities and ongoing developments embracing both radiology and nuclear medicine discipline. Imaging represents indeed the “trait d'union” for all the arguments described in the book; therefore, in most chapters there are dedicated sessions focused on the role of imaging in each specific context. The publication aims to fill the gap between the clinicians and all professionals directly involved in the management of patients with brain tumors and the newest scientific outreach. Moreover, thanks to the comprehensive insight into the latest technological developments, scientists and researchers interested in the topic will find the book a useful tool for future studies and perspective discoveries.

This publication is focused on neuronal and glioneuronal tumors of the central nervous system. Overall, these lesions are much less commonly encountered than their glioma counterparts. In the last 4 decades, the number of lesions that have been newly recognized as distinct entities in this arena has grown tremendously, due to the use of immunohistochemistry and most recently molecular studies. As a group, these tumors are important to distinguish from their glioma counterparts in that many of them have a better prognosis. This book will explore the clinical and pathologic features of these entities, including some of the recent molecular findings that have been discovered in some of these neoplasms.

Understand the fundamentals of human risk assessment with this introduction and reference Human risk assessments are a precondition for virtually all industrial action or environmental regulation, all the more essential in a world where chemical and environmental hazards are becoming more abundant. These documents catalog potential environmental, toxicological, ecological, or other harms resulting from a particular hazard, from chemical spills to construction projects to dangerous workplaces. They turn on a number of variables, of which the most significant is the degree of human exposure to the hazardous agent or process. Human and Ecological Risk Assessment combines the virtues of a textbook and reference work to introduce and analyze these vital documents. Beginning with the foundational theory of human health risk assessment, it then supplies case studies and detailed analysis illustrating the practice of producing risk assessment documents. Fully updated and authored by leading authorities in the field, the result is an indispensable work. Readers of the second edition of Human and Ecological Risk Assessment will also find: Over 40 entirely new case studies reflecting the latest in risk assessment practice Detailed discussion of hazards including air emissions, contaminated food and soil, hazardous waste sites, and many more Case studies from multiple countries to reflect diverse international standards Human and Ecological Risk Assessment is ideal for professionals and advanced graduate students in toxicology, industrial hygiene, occupational medicine, environmental science, and all related subjects.

Human Cancer Diagnosis and Detection Using Exascale Computing The book provides an in-depth exploration of how high-performance computing, particularly exascale computing, can be used to revolutionize cancer diagnosis and detection; it also serves as a bridge between the worlds of computational science and clinical oncology. Exascale computing has the potential to increase our ability in terms of computation to develop efficient methods for a better healthcare system. This technology promises to revolutionize cancer diagnosis and detection, ushering in an era of unprecedented precision, speed, and efficiency. The fusion of exascale computing with the field of oncology has the potential to redefine the boundaries of what is possible in the fight against cancer. The book is a comprehensive exploration of this transformative unification of science, medicine, and technology. It delves deeply into the realm of exascale computing and its profound implications for cancer research and patient care. The 18 chapters are authored by experts from diverse fields who have dedicated their careers to pushing the boundaries of what is achievable in the realm of cancer diagnosis and detection. The chapters cover a wide range of topics, from the fundamentals of exascale computing and its application to cancer genomics to the development of advanced imaging techniques and machine learning algorithms. Explored is the integration of data analytics, artificial intelligence, and high-performance computing to move cancer research to the next phase and support the creation of novel medical tools and technology for the detection and diagnosis of cancer. Audience This book has a wide audience from both computer sciences (information technology, computer vision, artificial intelligence, software engineering, applied mathematics) and the medical field (biomedical engineering, bioinformatics, oncology). Researchers, practitioners and students will find this groundbreaking book novel and very useful.

Brain organoids are small stem cell-derived, self-organizing models of specific brain regions that offer researchers new ways to study the human brain. Since their scientific debut over ten years ago, brain organoids have been used to generate tractable new bioengineered tools for understanding functional interconnectivity of the human brain, dysfunction involved in many neurodegenerative diseases, and certain molecular mechanisms underlying cognition. Despite this field's considerable scientific promise, advances in human brain organoid research also raise novel philosophical questions and ethical concerns around the use of complex human brain models and the ethical boundaries that should exist when manipulating increasingly realistic bioengineered brain constructs. As researchers generate more realistic organoids in vitro that resemble human brains, it is critically important to understand what ethical boundaries may exist and where researchers and regulators should draw the line for research, both to reduce uncertainties over which projects to pursue in the lab and to address future concerns regulators and the public may harbor about whether this research, if left unexamined, could inadvertently undermine public trust in science. This proposed book delves into ongoing and proactive ethical discussions among ethicists and the neuroscientists involved with this cutting-edge work. Its ultimate goal is to foster greater awareness, understanding, and guidance for future management of ethical issues that may be unique to new areas of brain organoid research. This volume is the result of a close partnership between ethicists and scientists, each informing the other through a collaborative process of joint bioethical deliberation.

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Jasper's Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for both clinical and basic science reference, doctoral and board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 79 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.

Viruses, bacteria, fungi and parasites are known to cause the most common human disease. It frequently spreads through direct contact (from human to human, animal to human), and through contaminated food or water. With the advancement of diagnostic techniques, it is now possible to rapidly identify microorganisms causing human disease and correlate with the corresponding clinical infection. Therefore, there is a need to develop robust and high-throughput diagnostic methods to prevent and control human disease of public health importance. This book entitled “Recent Advancements in the Diagnosis of Human Disease” will help the scientific community to better understand the transmission dynamics of some human diseases.

Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development covers the most important efforts of scientists and engineers worldwide to accelerate the process of discovery, production, and eventual market penetration of more potent antimicrobial peptides. These efforts have been fueled by emerging technologies such as artificial intelligence and data science, molecular and CFD simulations, easy-to-use process simulation packages, microfluidics, 3D-printing, among many others. Such technologies can now be implemented and scaled up quickly and at relatively low cost in low-budget production facilities, critical to moving to sustainable and marketable products worldwide. Discovering novel antimicrobial peptides rationally and cost-effectively has emerged as one of the significant challenges of modern biotechnology. Thus far, this process has been tedious and costly, resulting in molecules with activities far below those needed to address the current challenge of microbial resistance to antibiotics that takes the lives of thousands of people around the world every year. Finally, the book also highlights how multidisciplinary teams have assembled to address the challenges of manufacturing, biological testing, and clinical trials to finally reach complete translation. - Covers computational tools (including emerging artificial intelligence algorithms) and microfluidic systems for discovery and high-throughput screening of AMPs - Discusses the application of bioprocess engineering scale-up approaches for AMPs'production and purification with the aid of process simulation tools and rapid prototyping - Highlights user-centered design and formulation of products with AMPs - Describes the whole pipeline for AMPs production

Water Security: Big Data-Driven Risk Identification, Assessment and Control of Emerging Contaminants contains the latest information on big data-driven risk detection and analysis, risk assessment and environmental health effect, intelligent risk control technologies, and global control strategy of emerging contaminants. First, this book highlights advances and challenges throughout the detection of emerging chemical contaminants (e.g., antimicrobials, microplastics) by sensors or mass spectrometry, as well as emerging biological contaminant (e.g., ARGs, pathogens) by a combination of next- and third-generation sequencing technologies in aquatic environment. Second, it discusses in depth the ecological risk assessment and environmental health effects of emerging contaminants. Lastly, it presents the most up-to-date intelligent risk management technologies. This book shares instrumental global strategy and policy analysis on how to control emerging contaminants. Offering interdisciplinary and global perspectives from experts in environmental sciences and engineering, environmental microbiology and microbiome, environmental informatics and bioinformatics, intelligent systems, and knowledge engineering, this book provides an accessible and flexible resource for researchers and upper level students working in these fields. - Covers the detection, high-throughput analyses, and environmental behavior of the typical emerging chemical and biological contaminants - Focuses on chemical and biological big data driven aquatic ecological risk assessment models and techniques - Highlights the intelligent management and control technologies and policies for emerging contaminants in water environments

Pediatric and Adult Coeliac Disease: A Clinically Oriented Perspective provides an up-to-date, comprehensive, and critical overview of coeliac disease, its complications, and related disorders. The book covers the epidemiological, pathogenetic, diagnostic, and treatment issues including pediatric and adult cases, with a broad and international view. This is the perfect reference for researchers dedicated to advancing the field of translational coeliac disease research as well as clinicians who are diagnosing and managing coeliac disease throughout all of its various stages. - Provides a comprehensive and practical view, encompassing all disease forms and stages - Covers the clinical aspects of coeliac disease at all stages, providing deep clinical insights - Presents decision trees, tables, figures, and algorithms that aid in easily finding content to guide diagnosis

Goats are the predominant domestic livestock, and certainly the predominant small ruminant, in most of Asia, Africa and the warmer parts of Europe. Important for meat, milk, fibre and leather production, their widescale production and husbandry allows many opportunities for the spread of disease between livestock and their keepers. Taking a One Health approach to the issue, this book provides clear, accurate and comprehensive coverage of the zoonotic diseases of goats. Including information on aetiology, the epidemiology and transmission cycle, clinical symptoms, diagnosis, and prevention and control strategies, the book: - Helps readers quickly locate information about the disease's severity, mode of spread, treatment, and safety precautions; - Discusses the importance of educating animal owners about the public health implications of zoonotic diseases; - Reviews bacterial, viral, parasitic, rickettsial, and fungal diseases. An invaluable resource for veterinary practitioners and public health experts around the world, this book also provides a useful reference for researchers and students of animal disease and human health.

While the first edition of this book provided a succinct introduction to pediatric neuro-oncology, biological knowledge of childhood CNS tumors has “exploded” over the past few years and a new edition of this textbook is needed to keep it up-to-date. This updated edition will include chapters on cancer predisposition in children with brain tumors, gliomas, embryonal brain tumors, ependymoma, CNS-GCT, targeted therapies in pediatric brain tumors, and long-term sequelae. New developments covered include the following: - Techniques like DNA methylation have improved the diagnostic process, and have led to an integrated diagnosis of histology, ICH and methylation. - Tumor pathways have been detected, which defines more subgroups within a tumor entity, and results in more individualized treatment for the patient. - Therapeutic options outside the standard combination of surgery, chemotherapy, and radiation have either been implemented within the last years, or are currently under consideration. This book will be aimed at pediatric oncologists and neurooncologists, neurosurgeons, radiation oncologists. Chapters detailing quality of life and supportive care will make this 2nd edition a useful resource for nurses, social workers, physiotherapists, and occupational therapists alike.

This open access edited book connects two strands of federal studies, fiscal federalism, and diversity accommodation, to answer two closely interrelated questions. The first of these is to what extent has the need to accommodate diversities determined financial relations and their evolution? The authors answer this question by conducting a thorough investigation of the types of diversity that drive such evolution. The second question is does fiscal federalism have a broadly positive or negative impact on the accommodation of diversities, by producing institutional solutions that either integrate a federal system or pull it apart? Through contributions from experts in law, economics, and political science, the book uses a series of case studies to establish a theoretical framework for exploring the relationship between fiscal federalism and diversity accommodation. The authors lay the groundwork for a comparative study of this relationship in multilevel states.

Competition and Sustainability critically examines how the market economy can be preserved without compromising the Sustainable Development Goals of the UN. Serving as a useful overview of the problems and solutions found in one of the most controversial issues in current antitrust doctrine, this topical book offers concrete policy options for EU competition law.How can concerns over climate change, the supply chain, or animal welfare be integrated into antitrust? What can competition agencies do to help transform the market economy to a more sustainable one? Renowned experts in competition economics, law and sustainability answer these questions, and in doing so dissect issues such as cartels, exemptions, monopolisation, the environmental, social, and governance transformation, and merger control. Problems with government intervention in markets, quantification, and the danger of greenwashing are confronted with a thorough examination of the options for policy reform.This indispensable book tackles the transformation to the sustainable market economy with competition at its core. It will prove useful to academics in the fields of competition and antitrust law, corporate law and governance, European law, environmental law, and political economy, as well as policymakers and practitioners working in legal and economic fields.

This book is the first review book that uses the multiple-choice question format in neurosurgical oncology which mirrors the format of the majority of shelf and board examinations.The mission of the book is to help readers understand the content and maintain the knowledge, rather than merely finding answers for complicated questions. It provides more than 800 MCQs in a convenient format that is suitable for self-study. Answers and definitions appear immediately below the questions to facilitate information retention. The chapters provide comprehensive coverage of the core concepts in neurosurgical oncology. They provide a step-by-step, thorough explanations of each disease from the definition, associated anatomy, pathology, clinical features, radiology to surgical decision-making, and surgical tricks, providing a comprehensive and concise overview.This book is an adjunct to the existing texts and does not intend to be the primary source of information; it ratheraims to help readers identify their relevant strengths and weaknesses in the area. The book is an important asset for residents across neurosurgical disciplines as it includes much of the neuro-oncology knowledge that neurosurgical residents need to prepare for their certification tests. It is also useful for those seeking ways to solidify their knowledge or maintain their current certification.

Infectious diseases are caused by the pathogenic microbial organisms. These microbes can multiply and can cause an infection, once they enter the body. Infectious diseases are transmissible, and may cause mild to life-threatening illnesses. It can be airborne, waterborne, foodborne, and soilborne. It can be spread through direct contact (human to human, animal to human). It has also been one of the leading causes of human deaths. Therefore, there is a need to have rapid diagnostic methods to prevent and control these diseases. This book titled “Diagnosis of Pathogenic Microorganisms Causing Infectious Diseases” will help the scientific community to understand the transmission dynamics of some infectious diseases of public health importance.

This book highlights all newly reported carbon nanostructures including graphene and its derivatives, carbon nanotubes, metal organic frameworks, fullerenes, nanorods, nanospheres, nano onions, porous nanoparticles, nanohorns, nanofibers and nanoribbons, nanodiamonds, graphitic carbon nitrides, carbon aerogels and hydrogels, graphdiyne and graphenylene. It presents the historical development of carbon nanostructures technologies, different types and classifications, and different fabrication and functionalization techniques, including outer/inner surface functionalization and covalent and noncovalent functionalization. This Handbook discusses the unique properties of functionalized carbon nanostructures that can be obtained by modifying their structures, composition, and surface. It gives the reader an in-depth look at the current achievements of research and practice while pointing you ahead to new possibilities in functionalizing and using carbon nanomaterials. Finally, it covers the various applications of functionalized carbon nanostructures including adsorbents, additives, active materials in energy accumulating systems (batteries, hydrogen storage systems, and supercapacitors), filtering media, catalysts or supports for catalysts, sensors or substrates for sensors, additives for polymers, ceramic composites, metal and carbon alloys, glasses, digital textiles, and composite materials.

Greenfield's is the world's leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. The tenth edition features fully updated sections covering CNS tumours, neurodegeneration, skeletal muscle, epilepsy, paediatric and forensic neuropathology.Expert coverage from an international team of Editors and contributors ensures authoritative and up to date content. The two volume set includes a downloadable and easily used e-version. This is a tried and tested reference for scientists, clinicians, researchers, and students who wish to learn more about neurological disease.

This thought-provoking book explores the link between animals, people and their social and physical environments in relation to livestock farming, food safety, food security and sustainability. Providing an overview of livestock farming and animal related food production systems in a one welfare context, One Welfare: Animal Health and Welfare, Food Security and Sustainability begins by considering the interconnections of animals, humans and their environment. It then expands into the food production system, and considers the integration of positive welfare, stress, use of welfare indicators and the economic perspective. Written by a team of international experts, and with a foreword by Andrea Gavinelli, Head of the Animal Welfare Unit in the Health and Food Safety Directorate General of the European Commission, it connects theory with best practice examples and case studies from both organizations and individuals that have successfully implemented a one welfare approach. Essential reading for academics and practitioners who work within farming, food systems and international development, this ground-breaking text is also an important read for veterinary and animal welfare professionals.

This book contains three chapters focusing on the chemistry, toxicology, and environmental impact of pesticide residues. Chapter One reviews recent advances in the formulation of pesticides and their relationship to their efficacy and toxicity. Chapter Two is an overview of soil phytoremediation technologies. Chapter Three examines corbicular pollen as a potential source of information in agroecosystems.

Cancer is the second leading cause of death globally. Medicinal Plants and Cancer Chemoprevention provides information on the use of various herbal plants used as anticancer agents. It discusses the traditional system of medicine and focuses on plant-derived compounds for cancer therapy with integrated approaches. Chapters present information on various medicinal plants that covers background and history, ethnomedical considerations, morphology, phytochemistry, and pharmacological properties. The book presents a scientific investigation on medicinal plants in managing cancer, reported mechanisms of action as anticancer activity, as well as covering the toxicological aspects of certain plants.KEY FEATURES: Details information on plant-derived compounds for cancer therapy Features information on methods of extraction and isolation of various phytoconstituents responsible for anticancer activity Discusses herbal formulations and alternative approaches used for the management and treatment of cancer Demonstrates the importance of alternative approaches including yoga, acupuncture, and dietary supplements to be effective in the management of cancer This book is helpful to botanists, researchers and practitioners in alternative and complementary medicine, and the herbal medicine research community.

This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.

This book aims to gather the current knowledge regarding different aspects of brain and spinal cord tumors in order to more efficiently help the patients. Brain tumors comprise about 5–9% of all human neoplasms; and the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. The more we know about the nature and characteristic of brain and spinal cord tumors, the more precise decision could be made for each patient, in order to reach the best outcome. While surgical resection, chemotherapy, and radiotherapy have been considered as the standards of care for benign and/or malignant CNS tumors since a long time ago, new therapeutic approaches such as immunotherapy have been recently proposed to be considered for treatment of CNS tumors, especially as in some cases, the tumors might be inoperable or the patient may not benefit from other treatment modalities after several recurrences. The second volume of the book focuses on clinical aspects of these tumors. Accordingly, the most important brain and spinal cord tumors are specifically discussed in each chapter based on a rational outlining for all chapter in this volume: Background and epidemiology, genetics, immunology and molecular biology, histopathology and morphology, imaging and radiologic features, clinical manifestations, therapeutic approaches, surgical intervention, chemotherapy and radiotherapy, new therapeutic modalities, follow-up, and prognosis. The chapters of this volume discuss the following pathologies of brain and spinal cord tumors: malignant glioma, benign glioma, meningiomas and other meningeal tumors, ependymomas, medulloblastomas, pineal tumors, choroid plexus and ventricular tumors, neuroectodermal tumors of CNS, neuroepithelial tumors of CNS, pituitary gland tumors, craniopharyngioma, schwannomas and nerve-sheet tumors, hemangioblastomas and other vascular originating tumors, brain and spinal tumors of embryonic origin, germ line cell tumors, malignant bone or cartilage-originating tumors of brain and spine, benign bone or cartilage-originating tumors of brain and spine, brain tumors affecting the orbit globe and orbit tumors affecting the brain, CNS lymphomas, metastatic lesions of the brain and spine, malignant spinal tumors, benign spinal tumors, brain and/or spinal cord tumors accompanied with other diseases or syndromes, psychological and psychiatric aspects of brain and spinal cord tumors, a brief explanation on surgical approaches for treatment of different brain tumors. This volume of book is useful for physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists, and neuroradiologists.

Advanced Porous Biomaterials for Drug Delivery Applications probes cutting-edge progress in the application of advanced porous biomaterials in drug delivery fields. These biomaterials offer promise in improving upon the design, cost, and creation of potent novel drug delivery systems. The book focuses on two categories: nature engineered and synthetic advanced porous biomaterials, with a wide range of low-cost porous biomaterial-based systems that have been used for the delivery of diverse drugs through in vitro/in vivo approaches. Details how advanced porous biomaterial-assisted systems improve essential properties in drug delivery applications Explains how advanced porous biomaterials systems are being used and explored to improve overall performances of drug delivery systems in mitigating a variety of diseases Emphasizes major applications in drug delivery such as controlled release, cancer therapy, and targeted delivery, and with focus on oral, topical, and transdermal applications Focuses on both naturally available and synthetic low-cost advanced porous biomaterials and their role in enhancing important parameters in drug delivery applications Accessible to readers with bio and non-bio backgrounds This book is an ideal reference for academics, researchers, and industry professionals in the interdisciplinary fields of biomedicine and biomedical engineering, pharmaceuticals, materials science, and chemistry.

The book provides a comprehensive analysis of local government in federations. It fills the gap in current legal research and positions local government in federal studies through the lenses of comparative law, adopting a more nuanced approach to local government. The book considers the shortcomings between the black-letter constitution and its operational rules. Whether (and how) the regime of local government is implemented is more relevant than its formal-but-ineffective recognition. The comparative survey discloses the variety local institutions take in different federal contexts. Divided into three parts, the book comprises chapters investigating local government in systems that, to various degrees, have been examined and classified as federal. Scholars throughout the world have examined the federal-local connection in aggregative federations, (the USA, Canada, Switzerland, Germany, Australia, and Austria), devolutionary ones (Belgium, Bosnia Herzegovina, Italy, Spain, the UK, Argentina, Brazil, Mexico, and the Russian Federation), as well as in federations beyond the West, where federalism-as-a-colonial-legacy has undergone a process of reinvention affecting the federal-local connection (South Africa, Ethiopia, India, Nigeria, Comoros, Democratic Republic of Congo, Nepal, Palau, Federated States of Micronesia; St. Kitts and Nevis; United Arab Emirates; and Pakistan).

This edited volume covers all aspects of the Neglected Tropical Disease Scabies. The contributions are organised into four themed parts. The first part reviews the history of the disease and its treatment and management, part two is dedicated to parasitology and basic research on the disease causing parasite, Sarcoptes scabei. Epidemiology and disease burden including public health issues are discussed in the third part in detail. The last section of the book is covering clinical manifestation and management. This volume is the first one of its kind, providing an insight into all aspects of the skin disease which is causing considerable morbidity and mortality. Chapters are all written by dedicated experts in their respective area of interest making the publication a must have for all scientists and clinicians as well as public health specialists dedicated to Scabies research in any aspect.

This new book discusses plant-derived bioactive compounds, covering their sources, biological effects, health benefits, and potential prevention and treatment properties for multifactorial diseases. It first describes in detail how encapsulation methods and plant-based materials may be used in a variety of ways, covering the concepts, advantages, and techniques for encapsulating bioactives based on cereals, spices, and coffee. The volume also looks at the functional aspects of plant-based foods and nutraceutical-based functional food design. The role of functional foods in food safety and industrial food safety issues and techniques for monitoring food quality and safety are also addressed.

This updated reference covers diverse aspects of cerebellar development from a full range of viewpoints, including the epidemiology of cerebellar genetic disorders, developmental anatomy, cell biology, genetics, epigenetics, infectious diseases, and mechanisms involved in the regulation of cell fate, while also focusing on information that is relevant to clinicians caring for patients with cerebellar disorders. The chapters are written by experts in the field of cerebellar development, and the chapters cover diseases related to the cerebellum, along with their epidemiology, clinical features, assessment, and management. In addition to updating the content to cover the significant developments in the field since the first edition, the second edition will include new chapters on Non-Coding RNAs and Cerebellar Development, Development of the Fish Cerebellum, the Role of nNOS/NO on Cerebellar Development in Health and Disease, and rehabilitation in cerebellar ataxia. The effect of the COVID-19 on the cerebellum has been included in related chapters. Development of the Cerebellum from Molecular Aspects to Diseases, 2nd edition, is designed to be valuable reference for both neuroscientists and clinicians.

Mass Production of Beneficial Organisms: Invertebrates and Entomopathogens, Second Edition explores the latest advancements and technologies for large-scale rearing and manipulation of natural enemies while presenting ways of improving success rate, predictability of biological control procedures, and demonstrating their safe and effective use. Organized into three sections, Parasitoids and Predators, Pathogens, and Invertebrates for Other Applications, this second edition contains important new information on production technology of predatory mites and hymenopteran parasitoids for biological control, application of insects in the food industry and production methods of insects for feed and food, and production of bumble bees for pollination.Beneficial organisms include not only insect predators and parasitoids, but also mite predators, nematodes, fungi, bacteria and viruses. In the past two decades, tremendous advances have been achieved in developing technology for producing these organisms. Despite that and the globally growing research and interest in biological control and biotechnology applications, commercialization of these technologies is still in progress. This is an essential reference and teaching tool for researchers in developed and developing countries working to produce'natural enemies in biological control and integrated pest management programs. - Highlights the most advanced and current techniques for mass production of beneficial organisms and methods of evaluation and quality assessment - Presents methods for developing artificial diets and reviews the evaluation and assurance of the quality of mass-produced arthropods - Provides an outlook of the growing industry of insects as food and feed and describes methods for mass producing the most important insect species used as animal food and food ingredients

Schachner and Hansen's Pediatric Dermatology has been the gold-standard reference in pediatric dermatology for more than 33 years. The new edition is a comprehensive textbook covering all the skin conditions of children and adolescents in a two-volume masterwork that will meet the expectations of pediatric dermatologists, dermatologists, pediatricians and all who provide pediatric healthcare.

Since the first edition of this book in 2012, the field of molecular pathology has expanded exponentially. The advent of complete cancer genome sequencing, new diagnostic molecular tests, and biomarkers for targeted therapy and immunotherapy have demonstrated the importance of molecular tools both in patient care and in the practice of pathology. Furthermore, the development of many new molecular technologies has revolutionized the practice of modern pathology. The rapid growth of this field has led to an expansion of knowledge of molecular processes and many more clinical applications in our daily practice of surgical pathology. Thus, this updated second edition of Molecular Surgical Pathology aims to serve as the best available “quick reference” for pathologists, oncologists, geneticists, primary care physicians, and other medical professionals with an interest in this specialty. Molecular Surgical Pathology 2nd Edition focuses on the practical utility of molecular techniques and on molecular biomarkers for the practicing surgical pathologist. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis, as well as its implications for patient management and personalized care. This concise overview of molecular surgical pathology and molecular classification of tumors of different organ sites will help not only practicing physicians, but also those in training, including residents and fellows in various disciplines.

This textbook introduces to the fundamentals and applications of insect biotechnology in a concise manner. Global economically important insects such as silkworm, lac or honey bee are in the focus of this text. The book attempts to address all of the latest developments in this growing field such as application of metagenomics and proteomics in mining for genes and enzymes that could be beneficial in diverse industrial and biomedical applications. Further, insects have been established as suitable tool for the production of transgenic products which is discussed in one dedicated chapter. The book targets students and researchers in molecular biology, biotechnology or entomology who want to get familiar with the emerging field of insect biotechnology.

Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.Volume 2 gives (1) a detailed overview of the sesquiterpenes polypharmacology, (2) an interesting journey around the world of cannabinoids that reveals the development of new synthetic Δ9-THC derivatives, (3) the design of specific formulations to overcome the volatility of small sized terpenes-based essential oils, (4) an update on the latest generations of endoperoxides endowed with antimalarial activity and finally (5) a summary of MedChem strategies to fix the most common issues in formulating terpene derivatives (like low potency and poor solubility).The objective of this book set is to fulfill gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

The book is written and edited by an individual fortunate to see and work through the evolution of precision medicine in the last three decades. The book begins with an introduction to genomics and precision medicine, followed by a chapter on pediatric genomic sequencing and nine chapters focused on the pathologic diagnosis required for precision therapies in cancer. Tumors of the central nervous system (the brain and spinal cord) and the thyroid and salivary glands are described, including the most up-to-date World Health Organization (WHO) diagnostic pathologic classifications. The importance of the WHO classification of cancer in precision medicine is discussed. For hematolymphoid neoplasms, a detailed historical background for leukemia and lymphoma classifications precedes the comparison of the 5th edition WHO 2022 classification with the International Consensus Classification. Novel techniques in flow cytometry and measurable residual disease detection in hematolymphoid neoplasms by flow cytometry are described with ample illustrations. Other chapters include liquid biopsies in blood cancer, precision diagnosis in the lung, colorectal, ovarian, and prostate cancers, novel immunotherapies in cancer, including essential concepts underlying pathologic testing in cancer, and digital pathology and artificial intelligence as necessary tools for advancing precision medicine.