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b>Clinical Electrocardiography Electrocardiography is a transthoracic recording over a period of time. Electrical activity is detected and recorded via electrodes attached to the outer surface of the skin. The recording produced by this noninvasive procedure is termed as electrocardiogram. ECGs are used to measure the rate and regularity of heartbeats as well as the size and position of the chambers, the presence of any damage to the heart, and the effects of drugs or devices used to regulate the heart. Clinical Electrocardiography is the clearest and most accessible guide available to the application and interpretation of the ECG in clinical practice. The book proceeds from the belief that ECG patterns should not be memorized, but rather must be understood based on how they originate; it is only by achieving this level of understanding that clinicians can make the most informed diagnoses and thus manage patient care with complete confidence. This fully revised 5th edition: Gives clear information about the correct diagnoses of different heart diseases based on ECG alterations. Presents an exceedingly clear and linear approach to understanding the application and interpretation of the ECG in clinical practice. Explains the electrical activity of the heart and basic electrocardiographic principals. Offers guidance on normal ECG patterns and the changes various heart diseases produce in ECG morphology Provides a practical, deductive approach to the diagnosis of arrhythmias - one of the most challenging tasks for many clinicians Summarizes current knowledge of the clinical implication of rhythmic disturbances.

This book gives an overview of pharmacoproteomics and its clinical applications, as well as the latest information on drug mechanisms at the proteome level, the relationship between proteomics and toxicity or resistance, and how proteomics aid in discovery of new drug targets. The book also highlights recent advances in analytical methods, analysis, and interpretation of pharmacoproteomic data.Pharmacoproteomics: Recent Trends and Applications is an ideal book for those working in pharmaceutical industries, as well as scientists, health care professionals, and researchers who work in the field of genomics, pharmacology, pharmacokinetics, toxicology, and pharmaceutical chemistry.

This book provides clinicians with the information needed to effectively interpret the literature from observational and interventional cardiovascular outcomes studies. The book begins by providing a historical context of cardiovascular epidemiology, followed by chapters addressing key concepts in the study of cardiovascular disease such as the types of cardiovascular outcomes studies, basic and evolving design and statistical considerations, current guidelines for reducing atherosclerotic cardiovascular disease risk, surrogate markers of cardiovascular disease, challenges in developing evidence-based recommendations for non-pharmacological interventions, an overview of the pharmaceutical development process, and a detailed discussion of the clinical evidence supporting several factors and their relationships with atherosclerotic cardiovascular disease (lipids, inflammation, hemostasis, heart rhythm, blood pressure, diabetes, obesity, and chronic kidney disease). Cardiovascular Outcomes Research is a must-have resource for physicians and other clinicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.

This book is a compilation of ten chapters in Cardiovascular research from around the world. Chapter One starts off with ß -blockers and their use in the prevention of acute cardiac events. Chapter Two focuses on the emerging roles of extracellular chaperones and some of their associated cochaperones in cardiovascular disease and the appealing prospect for the development of novel pharmacotherapeutic strategies against the disease by targeting these complexes. The authors in Chapter Three review of previous trials suggest that coronary revascularization significantly reduces mortality and myocardial infarction rates in patients with stable coronary artery disease and moderate-to-severe ischemia. In Chapter Four, the authors provide diagnosis, risk factors and the management of heart failure with preserved ejection fraction. The objective of Chapter Five is to include the most current findings on the cellular pathophysiology of HFpEF and HFpEF-related comorbidities that are being discovered, which might eventually lead to more patient-specific medicines with clinical significance. In Chapter Six the authors describe the short-term clinical courses of seven hemodialysis patients receiving sacubitril-valsartan, as well as the long-term clinical courses of two anuric hemodialysis patients with reduced left ventricular ejection fractions after aortic valve replacement for aortic stenosis who showed improvement in cardiac function after the administration of sacubitril-valsartan. Chapter Seven speaks about the current issues in total arterial revascularization. Chapter Eight goes on to cover the advances in technology and interpretation software that have occurred in recent years. Chapter Nine highlights the significant transformations that monitoring systems have endured over history with details on the recording technique. The goal of the last chapter was to assess the prevalence of asymptomatic heart failure with preserved ejection fraction (HFpEF) in subjects at high risk of developing heart failure and to define the diagnostic accuracy of (N-terminal pro-B-type natriuretic peptide (NT-pro BNP) assay compared with echocardiography in this setting.

This book describes the basic concepts and recent advances in new discoveries and technologies related to microbial omics and their role in environmental research and human health. The term'omics'refers to a blend of high-throughput analysis and traditional methods including genomics, transcriptomics, proteomics, lipidomics and metabolomics for a variety of applications in the field of life sciences, biomedical sciences, environmental sciences, and related industries. The book aims to fill the existing gap in terms of a comprehensive approach that incorporates recent advances in this dynamic field and provides an answer to why this field requires an interdisciplinary research approach. The focus of this book is on the applications of genomics, epigenomics, metagenomics, integrative omics, machine learning and microbiome research in environmental health, disease, wastewater epidemiology, antibiotic resistance, drug discovery, cancer, production of secondary metabolites of microbial origin, oxidative stress alleviating mechanisms, etc. The overall construction of this book emphasizes three major perspectives, namely, elaborate knowledge from fundamentals to recent advances in technologies about omics in general and its application in microbiology, environment, and health in particular; illustrative figures capable of easy visualization of complex pathways; and serving as a platform for highly demanded bioinformatics strategies including relevant codes, programming scripts, machine learning and use of artificial intelligence strategies needed to streamline the research outcomes. With global contributions from authors from internationally renowned organizations who excel in relevant research, this book will benefit bibliophiles and prospective audiences from the research fraternity, academia, professionals, and experts in the field of life sciences, biomedical as well as industries related to the development of drug design and novel advances in biotechnological applications.

The concept of “vital amines” as essential nutrients was introduced over a century ago by Dr Casimir Funk. It was suggested that there is a family of organic substances that are required in minute amounts and essential for life. The increase in incorporation of vitamins and supplementation in routine dietary practices is expected to increase. In fact, it has been estimated that 60% of worldwide consumers are taking vitamin supplements on a daily basis, a trend that will most likely rise across the world.This book brings together international experts in the field of vitamins for human health and disease, to update and integrate current understanding on the effects of different lipophilic vitamins on cellular, metabolic and molecular biochemical reactions with respect to different pathophysiological conditions including cardiovascular disease, cancer, metabolic defects, inflammatory and immune diseases. This book is uniquely positioned as it focuses on the biochemistry and molecular biology of lipophilic vitamins in diverse cell systems in relation to human health and disease.The book will certainly stimulate and motivate biomedical researchers and scientists to further explore the relationship between lipophilic vitamins and biological processes, as well as serve as a highly useful resource for nutritional investigators, health professionals, medical students, fellows, residents and graduate students. We hope that the reader will gain knowledge and further understanding of the importance of lipophilic vitamins. The novel insights provided by the contributing authors will assist in advancing preventive medicine worldwide as well as bring forward knowledge that may help in the use of lipophilic vitamins as adjuvant to therapeutic strategies for human disease.

Bentham Briefs in Biomedicine and Pharmacotherapy showcases the latest developments and techniques in the fields of pharmacology and healthcare, presenting them in distinctive volumes. Each volume offers a concise, focused overview of subjects, authored by experts in the field. The book series serves as an anthology for graduate students and researchers in pharmacology and life sciences, as well as medical professionals seeking specialization for research-related projects.The second volume, Botanicals and Natural Bioactives: Prevention and Treatment of Diseases, discusses the medicinal applications of natural bioactives in the treatment of a variety of physiological disorders, including cardiovascular diseases, neurological dysfunctions, infectious diseases, age-related diseases, and cancer. The volume has eight chapters on disease treatment and preventative measures, with contributions from more than twenty experts. Readers will comprehend the niche utilization of botanicals and natural bioactives as medicinal agents for a variety of ailments. Overall, the chapters dwell on the chemosensory features of nutritious foods to avoid non-communicable diseases and the role of immunomodulating natural products and botanicals in the prevention and treatment of skin diseases, aging, inflammation, cancer, parasitic infections in the bloodstream, neurodegenerative diseases, osteoporosis, coronary heart disease, and autoimmune disorders. The variety of topics covered in this book makes it an excellent resource for a wide audience interested in phytomedicine.

The digital transformation of the health sector consistently presents unique challenges. As technologies like artificial intelligence, big data, and telemedicine rapidly evolve, healthcare systems need to keep up with advancements and data protection. This rapid evolution, compounded by the complexities of managing patient data and ensuring cybersecurity, creates a daunting task for healthcare providers and policymakers. The COVID-19 pandemic has also highlighted the urgent need for digital solutions, amplifying the pressure on an already strained sector. Improving Security, Privacy, and Connectivity Among Telemedicine Platforms is a comprehensive guide to navigating the digital revolution in healthcare. It offers insights into identifying vital digital technologies and understanding their impact on the Health Value Chain. Through an analysis of empirical evidence, this book provides a roadmap for effectively managing change, transition, and digital value creation in healthcare. With a focus on business sustainability, change management, and cybersecurity, it equips scholars, researchers, and practitioners with the tools needed to thrive in a rapidly evolving digital landscape. By delving into topics like telemedicine, Health 4.0, and knowledge management, this book offers practical solutions to the challenges posed by digital transformation. Through case studies and continuous improvement strategies, it empowers readers to implement change and embrace the digital future of healthcare. Whether you're a healthcare professional, researcher, or policymaker, this book will help you harness the power of digital technologies to revolutionize healthcare delivery and improve patient outcomes.

A systems-oriented look at how unhealed trauma can prevent optimal functioning—and what to do about it Trauma Impacts: Repercussions of Individual and Collective Trauma explores the many ways that traumatic experiences affect people from diverse backgrounds, as individuals and in groups. In chapters contributed by experts in their fields, this book offers a systemic overview of how trauma impacts all humans, then delves into the manifestations of trauma in specific populations like BIPOC communities, neurodivergent children, and those in helping professions. The book's third and final section looks at emerging modalities for working with trauma and implications for the future of trauma-focused therapy. Ideal for anyone who works closely with individuals who have experienced trauma—therapists, educators, social workers, and beyond—Trauma Impacts will benefit from a thorough understanding on how trauma continues to influence lives, even long after the fact. Trauma can interfere with meeting basic needs, forming healthy relationships, and finding fulfillment in the pursuit of individual and collective goals. When we conceptualize these impacts, we become empowered to help people process their traumatic experiences, integrate the pain they have experienced, and lead more satisfying lives. Understand the intersectional effects of trauma on individuals and systems Discover hope for healing through real-world voices and current research Consider how collective trauma manifests in the lives of individuals Gain insights that can help you work more effectively with clients

Nuclear cardiac imaging refers to cardiac radiological diagnostic techniques performed with the aid of radiopharmaceuticals, which are perfused into the myocardium as markers. These imaging studies provide a wide range of information about the heart, including the contractility of the heart, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist's armamentarium. Chapters in Nuclear Cardiac Imaging cover historical, technical and physiological considerations, diagnosis and prognosis, conditions other than Coronary Artery Disease (CAD), advanced cardiac imaging, and challenges and opportunities. New to the sixth edition are key point summaries at the start of each chapter, clinical cases with videos, and a question and answer chapter on practical issues. This volume is ideal for nuclear cardiologists in training and nuclear clinicians alike who are searching for quick answers to important clinical and technical questions.

This is a follow up of the authors'previous book entitled'Bioactive materials for bone regeneration. Generally speaking, human tissue can be classified as hard tissue such as bone and soft tissue such as skin, mussel, tendon, blood vessel, nerve etc. and including important organs such as heart, liver, lung. Regenerative medicine is dealing with both hard tissue and soft tissue regeneration and is one of the most important part of the modern medicine with significant clinical needs including general surgery, plastic surgery, burn and wound healing, cardiovascular disease treatments. Based on the authors'previous research and review of the international advances in hard tissue regeneration, this book focuses on the hard tissue regeneration using bioactive materials. It covers biomaterials for entire human tissue regeneration, which is key important for research and development in the field of biomedical engineering and the medical device industry. This book will give readers a comprehensive review of principal and the most updated advances of the research in bioactive materials for soft tissue repair and regeneration, and perspectives for the future directions of the research and development in this field. - Covers recent development of bioactive materials for soft tissue regeneration - Provides basic principles for design of bioactive materials for tissue regeneration - Includes future perspectives surrounding the development of bioactive materials that will be valuable to the readers

Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundaments to Applications provides the reader with a comprehensive, concise and thoroughly up-to-date resource on the different types of hydrogels in tissue engineering and regenerative medicine. The book is divided into three main sections that describe biological activities and the structural and physicochemical properties of hydrogels, along with a wide range of applications, including their combination with emerging technologies. Written by a diverse range of international academics for professionals, researchers, undergraduate and graduate students, this groundbreaking publication fills a gap in literature needed in the tissue engineering and regenerative medicine field. - Reviews the fundamentals and recent advances of hydrogels in tissue engineering and regenerative medicine applications - Presents state-of-the-art methodologies for the synthesis and processing of different types of hydrogels - Includes contributions by leading experts in engineering, the life sciences, microbiology and clinical medicine

This comprehensive book covers all aspects of cardiovascular health and disease. It begins with sections on cardiac diagnostic approaches like electrophysiology, ECG interpretation, cell death mechanisms, and myocardial perfusion imaging. A large section examines various cardiovascular diseases and related conditions, including gastroesophageal reflux disease, testosterone deficiency, multimorbidity, valvular disease, and rheumatic fever. Treatment strategies are covered next, with chapters on blood management techniques, infections of cardiac devices, anaesthesia for cardiomyopathies, and radiation safety in nuclear cardiology. The book then delves into advancements in the field such as artificial intelligence applications, cardiac resynchronization therapy, stress adaptation mechanisms, and more. Additional sections explore peripheral artery disease, patient cares like nursing for cardiac procedures, molecular pathways in myocardial hypertrophy, cardiac radiology, and mechanical cardiomyopathies. With its comprehensive scope and up-to-date information, this book serves as an invaluable tool for cardiologists, cardiothoracic surgeons, nurses, and any medical professional involved in caring for patients with cardiovascular disease. It also provides a solid foundation for students and residents training in the field.

This book is written by multidisciplinary specialists who diagnose and treat acute myeloid leukemia (AML) patients and is meant for anyone interested in the clinical care of patients with hematologic malignancies, including students and trainees. The 21 contributors for this book include expert clinicians in leukemia and hematologic malignancies, infectious diseases, pharmacological drug administration, pathology, cytogenetics, molecular genetics, and artificial intelligence, and one medical student and advanced trainees. The book comprises nine chapters, starting with a comprehensive overview of the global epidemiology, etiology, prognosis, treatment, and outcomes in patients with AML. Chapter 2 describes the classification of myeloid neoplasms, including AML, with a historical perspective and current diagnostic criteria. This chapter describes the fifth edition of the World Health Organization (WHO) classification and the updates from the revised fourth edition of the WHO classification. It compares the similarities and differences from the International Consensus Classification. Chapter 3 is focused on genetic evaluation in AML, emphasizing cytogenetic techniques, with numerous illustrations depicting genetic abnormalities in AML. Chapter 4 discusses measurable residual disease (MRD) in AML and explains the approaches and current guidelines for MRD detection by multiparametric flow cytometry and molecular techniques, emphasizing the pre-analytical, analytical, and post-analytical factors in evaluating MRD, with illustrations for essential concepts. Chapter 5 describes clonal hematopoiesis and its role in the development of myeloid neoplasms. Chapter 6 discusses inherited germline predisposition to myeloid malignancies, including inherited bone marrow failure syndromes and syndromic and non-syndromic predisposition syndromes for hematologic malignancies. Chapter 7 describes and illustrates novel therapeutic agents in AML, including genetically-targeted therapies, non-genetically targeted therapies, and immunotherapies. Chapter 8 covers the management of infectious complications in patients with AML, and Chapter 9 introduces the reader, with many illustrations, to the emerging applications of artificial intelligence in diagnostic hematopathology.

Textbook of Transplantation and Mechanical Support for End-Stage Heart and Lung Disease Comprehensive textbook covering all aspects of the care of patients with advanced heart or lung disease Transplantation and Mechanical Support for End-Stage Heart and Lung Disease is the most comprehensive and contemporary textbook available that addresses the medical and surgical treatment options for patients with end-stage heart and lung disease. All facets of these complex and resource-intensive therapies are covered by leading experts — including the basics of transplant immunology, databases, regulatory and ethical aspects of transplantation and conventional and new modalities of donor organ harvest. Transplantation and Mechanical Support for End-Stage Heart and Lung Disease includes further information on topics such as: Historical developments that facilitated heart and lung transplantation; engineering advances in continuous flow technologies Transplant organizations, oversight, structure, process, databases and registries in the thoracic transplants and MCS field Current strategies in immune modulation, desensitization protocols and mechanisms of allograft rejection and tolerance/immunosenescence Detailed descriptions of donor and recipient surgical procedures as well as comprehensive implantation techniques for all available short- and long-term mechanical circulatory support devices, including ECMO Organ allocation and prioritization, donor evaluation, high risk donors, marginal donors, and risk assessment Richly enhanced with summary tables and color illustrations to provide an engaging and supportive learning experience, the book will serve as a highly valuable source of contemporary knowledge for medical students, residents, nurses, perfusionists, physicians and surgeons involved in the care of these desperately ill group of patients. “This comprehensive book covers all aspects of advanced heart and lung failure treatment, including shock, short-term and durable mechanical assistance, as well as transplantation. The in-depth information will be welcome by newcomers in the field as well as seasoned veterans.” —Andreas Zuckermann, M.D Vice-Chair, Department of Cardiac Surgery, Director of Cardiac Transplantation Program, Medical University of Vienna, Vienna General Hospital “This comprehensive tour-de-force compendium covers practical issues of clinical administration, program development, care pathways, ongoing challenges and opportunities in each treatment area as a must go-to reference for guidance in the rapidly evolving fields of mechanical circulatory support and transplantation.” —Mandeep R. Mehra, MBBS, MSc, FRCP Executive Director, Center for Advanced Heart Disease, Brigham and Women's Hospital, Harvard Medical School “This unique textbook authored by key opinion leaders is a refreshing'wind of change'in our field, one that will well serve all professionals involved in the care of end-stage heart and lung patients for many years to come.” —Marcelo Cypel MD, MSc, FACS, FRCSC Surgical Director Ajmera Transplant Centre at UHN, University of Toronto

Diseases and Health Consequences of Air Pollution, Volume Three, Air Pollution, Human Health, and the Environment is part of a three-volume series. This volume focuses on epidemiological studies and diseases attributed to ambient and indoor air pollutants. It opens with an overview of diseases and health consequences due to air pollution. The chapters discuss health conditions such as respiratory issues, cardiovascular diseases, hypertension and blood pressure, diabetes, nervous system, brain, cancer, stroke—cerebrovascular disease, and skin disease that are linked to exposure to indoor and outdoor air pollutants. The book also evaluates the health cost and economic burden of air pollution and offers risk management and solutions to mitigate the health implications of indoor and ambient air pollution. This book provides a single source solution and the latest information about the diseases attributed to air pollutants and their health impact. It will be a valuable reference for academicians, researchers, and students in environmental health, public health, and occupational health, as well as environmental engineers, meteorologists, epidemiologists, medical researchers, and environmental toxicologists. - Discusses diseases attributed to air pollutants - Explains the mechanism of air pollutants on human organs - Examines human epidemiological studies and case studies on disease outcomes due to air pollutants - Covers health cost and economic burden evaluation of air pollution

Recent Developments in Nanomaterial-Based Sensing of Human Pathogens gives insights into the alignment of recent developments in the field of nano-sensing of bacterial and viral pathogenic organisms. The book describes the role of biomarkers in the detection of fungal diseases and the importance of mycoplasmas in health and diseases that are naturally resistant to many common antibiotics, such as penicillin. Touching all areas of medical microbiology and analytical biochemistry, this book provides understanding to application-oriented microbial sensing concepts and updates knowledge with respect to recent advances on related aspects of pathogenic sensing. - Presents in-depth coverage of nanosensors for a wide range of human pathogens - Combines insights from nanotechnology, biology, and medicine for holistic pathogen detection - Shows cutting-edge progress in analytics, biomarker detection, and innovative nanodevices for improved pathogen sensing - Highlights clinical importance, serving as a valuable resource for pathogen detection and diagnostics

This book presents a comprehensive and authoritative review of the recent developments and advances in biodegradable polymers and their biomedical applications. Following an interdisciplinary approach, it combines the medical and pharmaceutical fields in conjunction with biomedical engineering, polymer science, materials science, and pharmacological aspects of biodegradable polymers. The text covers the synthesis, properties, and characterization of biodegradable polymers and systems and their applications in sustained drug delivery, anticancer therapy, vaccine delivery, gene delivery, surgery, wound care, cardiology, dentistry, orthopedics, medical devices, tissue engineering, and cosmeceuticals. It also details the safety aspects, market economy, challenges, and opportunities related to biodegradable polymers, providing an understanding of the commercial and translational aspects of these crucial biomaterials. Edited and authored by renowned scientists working on biodegradable polymers, biocomposites, biodegradable systems, and implants, the book is an important resource for academicians, researchers, students, professionals, and general readers interested in exploring the potential biomedical applications of biodegradable polymers.

Selected peer-reviewed extended articles based on abstracts presented at the 6th International Conference on Science and Engineering (ICSE 2023)Aggregated Book

Selected peer-reviewed full text papers from the 6th International Conference on Science and Engineering (ICSE 2023)Selected peer-reviewed full text papers from the 6th International Conference on Science and Engineering (ICSE 2023), August 07-09, 2023, Yogyakarta, Indonesia

Arne Burkhardt, Walter Lang and Norbert Schwarz give an overview over mechanisms of damage that lead to death and health impairment after corona'vaccinations'. The Authors Arne Burkhardt and Walter Lang are pathologists with more than 40 years of professional experience. Together with, Norbert Schwarz, a medical scientist and epidemiologist, they examined more than 85 tissue samples from individuals, who had died after corona'vaccination'and more than 75 biopsy samples from individuals, who suffered serious health impairment. In parallel they reviewed the pertinent literature. This is a translation from German to English by one of the authors (Norbert Schwarz). No proofreading by a native speaker has been done.

Mitochondrial Transplantation and Transfer: Biology, Methods, Applications, and Disease, a volume in the Translational and Applied Bioenergetics series, offers a detailed overview of mitochondrial transplantation across fundamental biology, disease and early therapeutics research. Here, more than twenty experts in the field discuss transplantation and transfer of healthy mitochondria and define future steps to improve new therapeutic applications across a variety of diseases. Emphasis is placed on the physiology of mitochondrial transfer, isolation processes and their applications, transfer methods, and diagnostic and treatment use across cardiovascular, metabolic, and neurological diseases, among other disease types. Step-by-step instruction is provided around research protocols and methods discussed, along with careful attention to the ethical implications of mitochondrial transplantation research and application. - Provides an in-depth discussion of mitochondrial transplantation, considering fundamental biology, disease implications, research methods and applications - Discusses recent advances in the field and their meaning for future research and clinical utility - Considers ethical dimensions of mitochondrial transplantation research and use in therapeutics - Examines mitochondrial transplantation across a range of disease types, from neurological to cardiovascular disease and ischemia

Cardiac amyloidosis (CA) is caused by the accumulation of amyloid fibrils in the extracellular space of the myocardium, with clinical manifestations including conduction disturbances and heart failure. CA has traditionally been considered a rare disease, lacking effective therapies and with a poor prognosis, but in recent years, increased possibilities for non-invasive diagnosis and greater awareness of the disease have led to the identification of a growing number of cases, challenging the concept of CA as a rare disease. This is why the ability to recognise and manage patients with CA should become part of the core curriculum of cardiologists, but also of internal medicine specialists, general practitioners, neurologists, nephrologists and haematologists. This book, written by leading experts in the field, will provide the state-of-the-art in the diagnosis and management of CA and will also discuss the latest research developments and future research directions. Thevolume appears to be a timely one, given the great interest of clinicians and researchers in CA and the exponential increase in publications in recent year, and will be of interest to cardiologists, internal medicine and other disciplines specialists who may encounter patients with CA in their clinical practice, as well as general practitioners.

Nowadays, the field of microbiology is undergoing a revolutionary change due to the emergence of Artificial Intelligence (AI). AI is being used to analyze massive data in a predictable form, about the behavior of microorganisms, to solve microbial classification-related problems, exploring the interaction between microorganisms and the surrounding environment. It also helps to extract novel microbial metabolites which have been used in various fields like medical, food and agricultural industries. As the pace of innovation in Microbiology is accelerating, the use of AI in these industries will be beneficial. AI will not only show its extraordinary potential in expanding the market of antibiotics, food, and agriculture but also offer an eco-friendly, safer, and profitable solution to the respective industries. It would be challenging to search out specific features and discuss future research on AI in microbiology with a wide perspective. - Uncovering extended functions of AI in Microbiology. - Production and development of novel drug targets through AI. - Challenges for using and selecting appropriate AI tools in health, agriculture and food sector

Cellular, Molecular and Environmental Contribution in Cardiac Remodeling: From Lab Bench to Clinical Perspective consolidates the most recent research advances on cellular, molecular, biochemical, and heterogeneous factors contributing to the physiological and pathological cardiac remodeling, elucidating their mechanisms of action and the clinical outcomes of cardiac remodeling. It extensively covers the factors determining cardiac remodeling, including cardiomyocyte regeneration, cardiac stem cells and their therapeutic potential, cardiac resident pericytes, the role of natural bioactive compounds in cardiac remodeling, chronic cardiac adaptations to exercise and more. This book provides basic science researchers and clinical investigators in cardiology with a current and comprehensive resource on molecular mechanisms and contributing factors to cardiac remodeling, and its effects and impacts on heart health. New research areas for the future, aimed at preventing, limiting, and reversing bad remodeling, are also discussed. - Provides a concise summary of recent developments in cardiac remodeling research, combining novel information and the latest data published in this field - Discusses not only cellular and molecular factors impacting cardiac remodeling, but also environmental contributions such as lifestyle and exercise - Identifies areas for future research and potential novel strategies for translating basic research knowledge to applications in patients

Toxicodynamics in Drug Research, Volume 2: Public Health and Toxicology Issues examines the implications of public health issues and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments on human health. Volume 2: Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics covers topics on pharmacokinetics and toxicokinetics such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. The book investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body. It discusses the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. It also delves into the toxic effects of medical treatments and materials. Ethical, legal, societal, and professional issues in toxicology round off the coverage providing a valuable resource to interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments. - Discusses the impact of pharmaceuticals, food, and chemical toxicants on human health - Examines the toxic effects of medical treatments, clinical administrations, and materials - Explores public health issues around drug safety and toxicology

Supports clinicians in providing the best possible care to patients with serious illness The first comprehensive clinical guide for practicing palliative care and hospice clinicians, this evidence-based reference is designed to promote best practices in the delivery of safe, compassionate patient care. With a dual focus on evaluation and intervention, the book covers all aspects of providing palliative and hospice care for vulnerable and diverse populations. It provides an overview of common disease manifestations, typical trajectories of illness, symptom management, and recommendations for nursing care. Written in easy-to-access outline format, the resource is organized by body system and includes common diagnoses encountered in palliative and hospice care. Individual diagnoses include a definition, incidence, etiology, pathophysiology, predisposing factors, subjective and objective data, diagnostic tests, differential diagnoses, complications, disease-modifying treatments, palliative interventions/symptom management, prognosis, and nursing interventions. The text provides referral guidelines for serious illness as well as general and disease-specific hospice care admission guidelines. Also included are comprehensive tables of diagnostic testing, disease-specific palliative and symptom management interventions, prognostic and screening tools, patient teaching and clinician resources, and guides to pain management and wound care. Key Features: Delivers current guidelines for management of symptoms associated with serious illness Provides an in-depth review of common conditions seen in palliative and hospice care Organized by body system for quick information retrieval Delivers in-depth, evidence-based, and consistently organized disease-specific guidelines Presents hospice and palliative care management guidelines Contains reproducible patient/family education handouts Reviews procedures commonly used in hospice and palliative practice

The standard-bearer of critical care nursing guides―this succinct, comprehensive resource delivers the most current concepts for treating adult, critically ill patients and their families This engaging, evidence-based guide provides everything nurses and students need to know to provide safe, effective critical care. Endorsed by the American Association of Critical Care Nurses (AACN), and written by top experts in the field, this peer-reviewed guide covers all the essential details on the care of adult critical care patients and their families. Supported by helpful tables and algorithms, the book's practical, building-block organization starts with the basics before proceeding to more complex concepts. Whether you're going through orientation on the hospital floor or you're enrolled in critical care courses, AACN Essentials of Critical Care Nursing helps you care for every critical care patient. AACN Essentials of Critical Care Nursing, Fifth Edition is organized into four sections: The Essentials presents core information for providing safe, competent nursing care to all critically ill patients, regardless of their underlying medical diagnoses Pathologic Conditions covers conditions and management strategies commonly encountered among adult critical care patients Advanced Concepts in Caring for the Critically Ill Patient describes specific pathologic conditions that require specialized critical care management Key Reference Information features normal laboratory and diagnostic values, cardiac rhythms and their treatment and crisis standards of care

The standard-bearer of critical care nursing guides―this succinct, comprehensive resource delivers the most current concepts for treating adult, critically ill patients and their families This engaging, evidence-based guide provides everything nurses and students need to know to provide safe, effective progressive care. Endorsed by the American Association of Critical Care Nurses (AACN), and written by top experts in the field, this peer-reviewed guide covers all the essential details on the care of adult progressive care patients and their families. Supported by helpful tables and algorithms, the book's practical, building-block organization starts with the basics before proceeding to more complex concepts. Whether you're going through orientation on the hospital floor or you're enrolled in critical care courses, AACN Essentials of Progressive Care Nursing helps you care for every progressive care patient. AACN Essentials of Progressive Care Nursing, Fifth Edition is divided into four sections: The Essentials presents information you need to provide safe, competent nursing care to the majority of progressive care patients, with a wide range of underlying diagnoses Pathological Conditions covers pathologic conditions and management strategies commonly encountered among adult, progressive care patients Advanced Concepts offers advanced progressive care concepts to support the delivery of specialized care Key Reference Information features normal laboratory and diagnostic values; summary tables of cardiac rhythms, ECG characteristics, and treatment guides, and new crisis standards of care content

Plant-derived Hepatoprotective Drugs is a comprehensive guide that explores the world of medicinal plants and their hepatoprotective properties, offering both basic and applied insights for scholars and hepatology residents. Structured chapters provide a deep dive into the subject, while referencing relevant research and future perspectives. Readers will learn the science behind hepatotoxicity and the role of plants in safeguarding liver health. The book also helps researchers to explore bioactive compounds extracted from plants, along with herbal formulations that contribute to hepatoprotection, and conveys an understanding of the effects of edible plants and spices on liver wellness. A chapter focusing on isolation and characterization of phytochemicals bridges theory and application for discovering and developing hepatoprotective biopharmaceuticals. Key Features: Gives a thorough understanding of hepatotoxicity and related bioactive compounds Comprehensive references to enhance understanding Well-structured chapters providing organized knowledge Basic and applied information for diverse readers Future perspectives offering a glimpse into ongoing research This is an ideal reference for pharmacology scholars and residents in hepatology, as well as readers interested in nature's potential in promoting liver health.

This book analyses the basic rationale of noninvasive respiratory management in upper airways medical and perioperative disorders and key interactions and clinical implications. It offers key diagnostic tools to detect early and late failure of upper airway disorders whit a noninvasive approach. Furthermore, all medical and post-operative clinical indications of acute and chronic diseases in upper airway respiratory disorders and outcomes are summarized.The book can be considered unique from various perspectives: from the physiological and practical point of view as well as from the side of the therapeutic approach. As a matter of fact, from the physiological perspective, noninvasive mechanical ventilation has been shown to have several beneficial effects on the elasticity, musculature, and resistance of the upper and lower airways. Then, in the book the relationships between noninvasive respiratory management options and upper airway disorders in medical and postoperative conditions are also considered. Finally, the book provides information and analysis of the interaction of upper airways in the interaction of noninvasive mechanical ventilation management, which are the determining factors in the response in various clinical settings. Considering the growing evidence of the role of upper airways disorders in influencing the outcomes of noninvasive mechanical ventilation, in this book is presented a unique multidisciplinary approach to better understand the role of upper airways in noninvasive mechanical ventilation. The volume – richly illustrated – offers an exhaustive analysis of the role of the upper airways in patients who require treatment with noninvasive mechanical ventilation and can be considered a scientific reference for several specialists such as intensivists and anesthesiologists, pneumologists-sleep medicine professionals as well as otorhinolaryngologists.

Use THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on Expert Consult — featuring the comprehensive product with fully searchable text, regular content updates, animations, podcasts, over 1300 clinical case studies, lecture series, and more. - Authoritative, current content helps you perform tests in a cost-effective, timely, and efficient manner; provides expertise in managing clinical laboratory needs; and shows how to be responsive to an ever-changing environment. - Current guidelines help you select, perform, and evaluate the results of new and established laboratory tests. - Expert, internationally recognized chapter authors present guidelines representing different practices and points of view. - Analytical criteria focus on the medical usefulness of laboratory procedures. - Use of standard and international units of measure makes this text appropriate for any user, anywhere in the world. - Elsevier eBooks+ provides the entire text as a fully searchable eBook, and includes animations, podcasts, more than 1300 clinical case studies, over 2500 multiple-choice questions, a lecture series, and more, all included with print purchase. - NEW! 19 additional chapters highlight various specialties throughout laboratory medicine. - NEW! Updated, peer-reviewed content provides the most current information possible. - NEW! The largest-ever compilation of clinical cases in laboratory medicine is included with print purchase on Elsevier eBooks+. - NEW! Over 100 adaptive learning courses included with print purchase on Elsevier eBooks+ offer the opportunity for personalized education.

Stem Cells and Signaling Pathways provides mechanistic insights into the role of stem cells to combat the COVID-19 outbreak and other pathologies where a cytokine storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. The advent of SARS-CoV-2 resulted in a global pandemic, putting individuals with other comorbidities at a higher risk of infection. The whole world witnessed a massive shortage of medical and other essential supplies needed to combat the virus. That said, stem cell therapy has emerged as a potential treatment for viral diseases, including but not limited to COVID-19. Interestingly, the clinical trials in the patients having COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue. • Provides a compilation of chapters dedicated to the study of the field with respect to properties of stem cells and their signaling pathways. It also provides detailed information on signaling pathways associated with stem cells.• Provides a detailed and updated view of stem cell biology.• Covers a wide range of areas within basic and translational research appropriate for scientistsand clinicians engaged in studying the treatments for diseases from interdisciplinary perspectives.• Highlights the use of different models for stem cell research, significance of stem cell signaling in drug discovery.

This digital update on “Cardio-Diabetes Medicine 2023” is a compendium of the Scientific proceeds of GCDC 2022 at Chennai on 24th and 25th of September 2022. The aim of the book is to throw more light in the areas where they are grey. Cardiodiabetology has grown in the tertiary care level where it is managed with cut end technology.

The second edition of this book updates, reviews, and discusses the latest findings on the pathophysiology, diagnosis, and management of cardiovascular disease in the older patient. It explains the physiological changes associated with the normal aging process that may lead to the development of disease, to adverse consequences once disease develops, and which alter the risk-benefit equation for medical and other interventions designed to diagnose, assess, and treat cardiovascular disease. Chapters address key issues in the management of cardiovascular disease in the elderly including prevention, coronary artery disease, valvular disease, hypertensive disease, arrhythmias, and interventions. Wherever possible, the authors take an evidence-based approach to recommendations and rely heavily on clinical trials. The value of lifestyle changes in the aging population, the use of primary and secondary prevention strategies, treatments, and complications are also discussed. Cardiovascular Disease in the Elderly offers physicians and other related providers who care for older patients a gold-standard approach to understanding and managing cardiovascular disease in this group.

This well-accessible textbook constitutes a practical guide to metabolomics approaches and applications in an integrative manner. Illustrated by numerous real-life examples and case studies the book teaches how to set up and carry out metabolomics experiments, from sample collection to storage techniques, and guides the reader through the potentials and challenges of metabolite analysis. In addition, this textbook shows how to obtain insights into molecular mechanisms deployed in different physiological contexts (e.g., exercise, healthy ageing) as well as in different (metabolic) diseases, be it Diabetes, Cancer, Alzheimer´s Disease, Asthma or others. The book brings together knowledge from biochemical, biological, and medical aspects, and further equips the reader with know-how from sample collection and handling to data processing, analysis and interpretation. This textbook is a must-have for advanced undergraduates and graduate students interested in applied biochemistry and metabolomics, as well as for instructors who teach courses in biomedicine, physiology or biochemistry.

This contributed volume compiles the latest improvements in the field of nanobiotechnology, with a special emphasis on microbial-synthesized nanoparticles. It focuses on topics that comprise the microbials synthesized nanoparticles, their characterization, and applications in the field of medicine and biotechnology, which are organized in three parts, respectively. Ranging from micro-scale studies to macro, it covers a huge domain of nanotechnology in relevance to microbiology. Overall, the book portrays the importance of microbial processes in the sustainable production of nanomaterials to reduce the environmental burden caused by nanomaterials produced by chemical processes. The book is a ready reference for practicing students, researchers of nanobiotechnology, environmental biotechnology, and other allied fields likewise.

The present is bundled with several unique features. It provides up-to-date information on electrocardiograms for almost all electrocardiographic abnormalities covers all aspects of surface electrocardiography in detail. Summaries follow all book chapters for quick revision and MCQs for self-assessment. This book will be helpful to clinicians, fellows in medicine preparing for different careers in cardiology, and ECG technicians and their teachers.The purpose of writing this book - While teaching undergraduates, postgraduates in general medicine, and students of diploma course in cardiac instrument technology, I realized that the students did not have the knowledge of basic concepts of electrocardiography and did not know the clinical significance of various abnormalities. Students, therefore, felt that the subject was difficult to understand and of no clinical significance. Students, therefore, did not feel interested. There was a need for a book that couldsimplify the subject to the ground level for a beginner who does not know even the basics of electrocardiography. Most of the books in this field are targeted towards cardiologists with an understanding that the reader already has enough knowledge of the basic concepts of electrocardiography. MCQs are the cornerstone for learning, teaching, and evaluation. None of the books in the market gives the idea of MCQs in electrocardiography. What problem does this book solve for the readers? - This book explains various normal and abnormal findings with the help of diagrams and illustrative electrocardiograms. Clinical implications of multiple abnormalities are discussed. This makes the subject easy to understand and to interest for a beginner. MCQs will help the readers in self-assessment. MCQs will also help teachers and examiners in evaluating the students.

Cartilage, Tissue and Knee Joint Biomechanics: Fundamentals, Characterization and Modelling is a cutting-edge multidisciplinary book specifically focused on modeling, characterization and related clinical aspects. The book takes a comprehensive approach towards mechanics, fundamentals, morphology and properties of Cartilage Tissue and Knee Joints. Leading researchers from health science, medical technologists, engineers, academics, government, and private research institutions across the globe have contributed to this book. This book is a very valuable resource for graduates and postgraduates, engineers and research scholars. The content also includes comprehensive real-world applications. As a reference for the total knee arthroplasty, this book focuses deeply on existing related theories (including: histology, design, manufacturing and clinical aspects) to assist readers in solving fundamental and applied problems in biomechanical and biomaterials characterization, modeling and simulation of human cartilages and cells. For biomedical engineers dealing with implants and biomaterials for knee joint injuries, this book will guide you in learning the knee anatomy, range of motion, surgical procedures, physiological loading and boundary conditions, biomechanics of connective soft tissues, type of injuries, and more. - Provides a comprehensive resource on the knee joint and its connective soft tissues; content included spans biomechanics, biomaterials, biology, anatomy, imaging and surgical procedure - Covers ISO and FDA based regulatory control and compliance in the manufacturing process - Includes discussions on the relationship between knee anatomical parameters and knee biomechanics

Animal Assisted Therapy Use Application by Condition provides the most updated and comprehensive data knowledge on animal-assisted therapy. The book synthesizes historical information, theory, clinical practice, and data from recent clinical studies on animal-assisted therapy for post-traumatic stress disorder (PTSD) and other diseases. Written by international experts drawn from the fields of medicine, clinical psychology and therapy, speech therapy, clinical research, and animal training and welfare, this book employs a hypothesis driven, data rich approach to inform readers on current research and serve as a reference for clinical practice and use of animal-assisted therapy. This is an important resource for clinicians, researchers, animal trainers and handlers and students who want to understand and utilize animal-assisted therapy in theory and practice. - Includes essential information on animal-assisted therapy for clinicians, researchers, students, and animal training and handling organizations - Examines PTSD in history, literature and arts, along with theories of the mechanism of clinical action of animal-assisted therapy - Features contributions by war combat veterans who use animal-assisted therapy for the treatment of PTSD

This book provides comprehensive information and clarity on all aspects of diagnosing and managing constrictive pericarditis. The operative procedures for constrictive pericarditis are presented in detail with technical tips supplemented by surgical videos. Further, it explores and guides on issues with mixed opinions like the role of corticosteroids, timing of the operation, choice of the operative procedure, terminologies to describe the extent of decortication, and the requirement of cardiopulmonary bypass. Despite experience spanning over 100 years, there is no fool-proof formula in the published literature that can be used in selecting an optimal surgical approach for a given patient. The terms'radical','total','extensive','complete','subtotal','adequate','near-total'and'partial'pericardiectomy also have been variably used in the literature, often without a precise definition of the limits of pericardial resection.Providing an update on the latest advancements and long-term results of pericardiectomy appeals to all clinicians managing constrictive pericarditis. For the trainees, it offers insights into surgical techniques'relevant anatomy and foundation. The book will be beneficial to MBBS, MD, MS, M.Ch (CTVS), DM (Cardiology), Diplomate of National Board (Cardiology and CTVS), FRCS, FRACS, MD (USA, Canada, and in all developing and developed countries).

Epigenetic alterations are heritable changes that play a key role in human development and tissue-specific gene expression patterns. These changes can lead to alterations involved in tumor formation, imprinting, and metabolic disorders. Recent advances can help us understand the importance of epigenetic changes in both cancer development and tumor progression. In addition, epigenetic alterations may also be useful diagnostic and prognostic markers for the analysis of tumor progression.Split into two parts, the book opens with a comprehensive overview of the identification and analysis of epigenetic changes in cancer and the consequences of such changes during tumor development. The second part focusses on cancer specific epigenetic alterations and discusses the potential use of epigenetic markers as biomarkers in diagnosis, early cancer progression, and prognosis. Moreover, it reviews the therapeutic potential of epigenetic drugs. Given its scope, Cancer Epigenetics is an indispensable resource not only for researchers working in the field of human epigenetics and cancer research but also for advanced students seeking for an introduction into epigenetic mechanisms.

This book is an illustration-rich practically focused resource on the use of cardiopulmonary point of care ultrasound (POCUS). It focuses on the applications of POCUS in a wide range of medical specialties especially critical care medicine, cardiology, emergency and respiratory medicine. Topics covered include the application of POCUS in diagnostics, monitoring of various cardiorespiratory conditions such as pulmonary edema, and the role it can perform in guiding interventions for pleural and pericardial effusion. Stunning illustrations and instructive accompanying video clips ensure that the reader can develop a deep understanding of how to properly apply the technology into day-to-day clinical practice. Cardiopulmonary Point of Care Ultrasound is edited and authored by a group of world-renowned experts in the field of critical care echocardiography and POCUS from critical care medicine, cardiology, respiratory medicine, emergency medicine, surgery, radiology and cardiac physiology with a powerful multi-specialty and multi-disciplinary collaboration. It offers detailed insight into the applications of this technique and associated technologies across medical specialties with a focus on cardiorespiratory disorders. The user-focused emphasis in this resource makes it an ideal bedside manual for both experienced practitioners and trainees in these fields.

This volume of the Springer book series Advances in Experimental Medicine and Biology covers potency assays, one of the most complex yet fundamental evaluations that critically influence stem cell regenerative medicine. Developing potency assays for cell-based medicinal products comes with numerous challenges due to the highly specialised nature of the application and purpose. This book provides the reader with the knowledge necessary to understand issues governing the successful development of potency assays, highlighting an international outlook of how the various challenges raised are being managed. Stakeholders concerned with potency assay development range from patient and clinician to contract research organisations, small and medium enterprise, regulatory authorities and even politicians. The value of potency assays is poised to increase given the inevitable watershed as early-stage clinical trials addressing safety progress to trials testing efficacy. Contributors fromclinical, academic, industrial and regulatory sectors establish a broad point of view for guidance and timely debate. Potency assays require extensive collaboration across disciplines and sectors, as well as compromise and the authors aim to constructively address the many key aspects involved.Potency assays provide a quantitative measure of the biological activity of advanced therapy medicinal products (ATMPs) and thus are required for their market authorization. As the pace of ATMP development accelerates, the need to develop specific, accurate, and robust potency assays for each product is also accelerating. The volume Potency Assays for Stem Cell Advanced Therapy Medicinal Products presents a broad outlook on the development, quality attributes, and implementation of potency assays for ATMPs. The first few chapters introduce a nuanced historical perspective on the science of potency assay development, describe specific quality attributes of an idealized potencyassay, indicate pitfalls associated with developing such assays for ATMPs, and review guidance recommended by regulatory authorities on assay suitability for product approval. Subsequent chapters highlight efforts to develop potency assays for specific ATMPs, including skeletal stem cells, mesenchymal stromal cells, extracellular vesicles, CAR T-cells, and discuss emerging technologies/platforms for potency assay design. The volume concludes with a chapter reviewing potency assays used for the release of commercial ATMP products, which amalgamates information contained in previous chapters. Overall, the knowledge contributed from leading authorities in both academia and industry is an ideal resource for technicians, scientists, clinicians, process engineers, and regulators working with ATMPs.—Donald G. Phinney, PhD Professor, Department of Molecular Medicine, Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their detection by biomarkers.Biomarkers and methods used in critical care and critically ill patients are discussed, as well as biomarkers in trauma and special conditions. Specific biomarker components are explained and models for modeling trauma in research are presented.This systematic handbook is an excellent resource for researchers and specialists in trauma research and treatment, as well as clinicians and physicians who want a thorough overview of various injuries, trauma, and their detection methods.

Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology). This second edition revisits and expands each section, with entries on topics not covered in the first edition, including Crispr. The whole work is updated, providing greater coverage of specialized cell function and translational applications, and putting greater emphasis on these topics in graduate/medical teaching. New overview chapters and subsections provide a simplified cell biology text that can be used by instructors. The new version includes a standard template for each chapter, making the content easier to navigate, as well as inserts and graphics which provide summaries of key points in each chapter. - Provides the authority of a team of outstanding scientists in the field - Presents a comprehensive, up-to-date resource, covering both basic and translational aspects of cell biology - Offers high quality content at a competitive market price

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series'Cell Biology and Translational Medicine (CBTMED)'as part of Springer Nature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 18th volume of a continuing series.

Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies. - Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications - Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs - Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways - Each chapter updated to include summaries, definitions, and vibrant imagery and figures to reinforce understanding - Features step-by-step methods and disease research case studies to put book concepts into practice

Informed by the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health examines multiple aspects of child and adolescent development and physical and mental health. According to the Biopsychosocial Model, health is determined by the reciprocal interactions between biological (e.g., genetics, physical development, family health history), psychological (e.g., mental health, identity developmental, attitudes), and social (e.g., family, peers, school, social supports) factors. This theory posits that each one of these factors alone is not sufficient to understand health; instead, it is important to understand how these interactive components ultimately influence health outcomes. In addition to the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health has a translational approach. Each section and all applicable entries include a discussion of prevention or intervention efforts that can inform health and health promotion, and prevent health risks. - Presents a comprehensive review of current child and adolescent research, along with critical insights into the future direction of the field, including translation and prevention - Includes concise, authoritative chapters that are expertly authored make this an easy-to-read, reliable reference resource - Provides a clear thematic structure that allows for easy exploration across the discipline's different sub-fields. - Helps readers find their topics of interest, all of which are contextualized and linked to relevant literature

This textbook describes several diseases and clinical conditions, from physiopathological mechanisms to main clinical pictures, highlighting the importance of laboratory medicine, with the aim to provide the necessary tools for guiding correct laboratory findings interpretation. Indeed, it is now widely recognized that laboratory medicine has a pivotal role in clinical medicine, significantly influencing clinical decisions. Thus, it is crucial to understand and use laboratory data appropriately. This book has the great advantage of describing each topic exhaustively in order to facilitate its understanding. Specifically, it describes both diseases with a high incidence in the population, such as Diabetes Mellitus, Cardiovascular Diseases, Dyslipidemias, and Autoimmune Diseases, as well as rare diseases, such as Hereditary Metabolic Diseases. In addition, unusual topics are treated, such as Clinical Biochemistry of the Mind, as well as hot topics, such as Biological Drugs, Biobanks, Health Technology Assessment, and Omics Sciences. Finally, the book includes a chapter on the new health emergency, the SARS-CoV-2 pandemic. Two appendices are provided at the end of the book: a table summarizing the reference range and decisional cut-off for the main laboratory parameters and instructions on performing a venous blood sample. The book will be an invaluable tool for medical and biomedical students, as well as for practitioners.