1. Cassane-type Diterpenes from the Seeds of Caesalpinia minax with Their Antineoplastic Activity.
- Author
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Guo-Xu Ma, Xu-Dong Xu, Li Cao, Jing-Quan Yuan, Jun-Shan Yang, and Li-Yan Ma
- Subjects
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CHROMATOGRAPHIC analysis , *ANTINEOPLASTIC agents , *CELL culture , *CISPLATIN , *DOXORUBICIN , *MASS spectrometry , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *PHARMACEUTICAL chemistry , *RESEARCH funding , *SEEDS , *TERPENES , *TOXICITY testing , *DESCRIPTIVE statistics - Abstract
Five new cassane-type diterpenes, neocaesalpin AA (1), neocaesalpin AB (2), neocaesalpin AC (3), neocaesalpin AD (4) and neocaesalpin AE (5), were isolated from Caesalpinia minax together with three known compounds, 12α-methoxyl, 5α, 14β-dihydroxy-1α, 6α, 7β-triacetoxycass-13 (15)-en-16,12-olide (6), spirocaesalmin (7) and magnicaesalpin (8). Their structures were elucidated based on 1D and 2D NMR, MS and CD analyses. Compounds 1-6 were tested against Hela, HCT-8, HepG-2, MCF-7 and A549 cancer cells and showed moderate cytotoxicity with IC50 values from 18.4 to 83.9 µM. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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