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Your search keyword '"CYTOCHROMES"' showing total 2 results
2 results on '"CYTOCHROMES"'

1. Metabolism, Role in Immunotoxicity.

Author

Tae Cheong Jeong and Vohr, Hans-Werner

Subjects
*METABOLITES, *BIOMOLECULES, *CYTOCHROME P-450, *CYTOCHROMES, *CARCINOGENS
Abstract

The entry examines the immunosuppresive effects of metabolites. Isozyme-selective inducers and inhibitors have been developed in order to detect immunotoxicants requiring metabolic activation by cytochrome P450s. Drug-metabolizing enzymes such as cytochrome P450s play a role in activating human carcinogens therefore it can be speculated that certain immunotoxicants might require metabolic activation in humans.

Published
2005

2. Metabolite.

Author

Vohr, Hans-Werner

Subjects
*METABOLITES, *DEFINITIONS, *XENOBIOTICS, *ENZYMES, *CYTOCHROME P-450, *CYTOCHROMES
Abstract

A definition of the term "metabolite" is presented. It refers to a product of xenobiotic biotransformation. Some drug-metabolizing enzymes can produce reactive metabolites such as cytochrome P450 which can cause immunotoxicity.

Published
2005

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