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Odd radio circles (ORCs) are a newly discovered class of extended faint radio sources of unknown origin. We report the first detection of diffuse X-ray gas at the location of a low-redshift ORC (z = 0.046) known as Cloverleaf ORC. This observation was performed with the XMM-Newton X-ray telescope. The physical extent of the diffuse X-ray emission corresponds to a region of approximately 230 kpc by 160 kpc, lying perpendicular to the radio emission detected by ASKAP. The X-ray spectrum shows characteristics of thermal multiphase gas with temperatures of 1.10 ± 0.08 keV and 0.22 ± 0.01 keV and a central density of (4.9 ± 0.6)×10−4 cm−3, indicating that the Cloverleaf ORC resides in a low-mass galaxy group. Using X-ray observations, with hydrostatic equilibrium and isothermal assumptions, we measure the galaxy group to have a gas mass and a total mass of (7.7 ± 0.8)×1011 M⊙ and 2.6 ± 0.3 × 1013 M⊙ within the overdensity radius R500. The presence of a high-velocity subgroup identified in optical data, the orientation of the brightest cluster galaxy, the disturbed morphologies of galaxies toward the east of the Cloverleaf ORC, and the irregular morphology of the X-ray emission suggest that this system is undergoing a galaxy group merger. The radio power of the ORC could be explained by the shock reacceleration of fossil cosmic rays generated by a previous episode of black hole activity in the central active galactic nucleus. [ABSTRACT FROM AUTHOR]

The paper presents the analysis of optically selected GAMA groups and clusters in the SRG/eROSITA X-ray map of eROSITA Final Equatorial Depth Survey, in the halo mass range 1013−5 × 1014 M⊙ and at z < 0.2. All X-ray detections have a clear GAMA counterpart, but most of the GAMA groups in the halo mass range 1013−1014 M⊙ remain undetected. We compare the X-ray surface brightness profiles of the eROSITA detected groups with the mean stacked profile of the undetected low-mass haloes at fixed halo mass. Overall, we find that the undetected groups exhibit less concentrated X-ray surface brightness, dark matter, and galaxy distributions with respect to the X-ray-detected haloes. The mean gas mass fraction profiles are consistent in the two samples within 1.5σ, indicating that the gas follows the dark matter profile. The low-mass concentration and the magnitude gap indicate that these systems are young. They reside with a higher probability in filaments while X-ray-detected groups favour the nodes of the Cosmic Web. Because of the lower central emission, the undetected systems tend to be X-ray underluminous at fixed halo mass and to lie below the LX − M halo relation. Interestingly, the X-ray-detected systems inhabiting the nodes scatter the less around the relation, while those in filaments tend to lie below it. We do not observe any strong relationship between the system X-ray appearance and the active galactic nucleus (AGN) activity. We cannot exclude the role of the past AGN feedback in affecting the gas distribution over the halo lifetime. However, the data suggests that the observed differences might be related to the halo assembly bias. [ABSTRACT FROM AUTHOR]

We report the first statistical detection of X-ray emission from cosmic web filaments in ROSAT data. We selected 15 165 filaments at 0.2 <  z <  0.6 ranging from 30 Mpc to 100 Mpc in length, identified in the Sloan Digital Sky Survey survey. We stacked the X-ray count-rate maps from ROSAT around the filaments, excluding resolved galaxy groups and clusters above the mass of ∼3 × 1013 M⊙ as well as the detected X-ray point sources from the ROSAT, Chandra, and XMM-Newton observations. The stacked signal results in the detection of the X-ray emission from the cosmic filaments at a significance of 4.2σ in the energy band of 0.56−1.21 keV. The signal is interpreted, assuming the Astrophysical Plasma Emission Code model, as an emission from the hot gas in the filament-core regions with an average gas temperature of 0.9−0.6+1.0 0. 9 − 0.6 + 1.0 $ 0.9^{+1.0}_{-0.6} $ keV and a gas overdensity of δ ∼ 30 at the center of the filaments. Furthermore, we show that stacking the SRG/eROSITA data for ∼2000 filaments only would lead to a ≳5σ detection of their X-ray signal, even with an average gas temperature as low as ∼0.3 keV. [ABSTRACT FROM AUTHOR]

The variation of galaxy stellar masses and colour types with the distance to projected cosmic filaments are quantified using the precise photometric redshifts of the COSMOS2015 catalogue extracted from Cosmological Evolution Survey (COSMOS) field (2 deg2). Realistic mock catalogues are also extracted from the lightcone of the cosmological hydrodynamical simulation Horizon-AGN. They show that the photometric redshift accuracy of the observed catalogue (σz < 0.015 at M* > 1010M⊙ and z < 0.9) is sufficient to provide two-dimensional (2D) filaments that closely match their projected three-dimensional (3D) counterparts. Transverse stellar mass gradients are measured in projected slices of thickness 75 Mpc between 0.5 < z < 0.9, showing that the most massive galaxies are statistically closer to their neighbouring filament. At fixed stellar mass, passive galaxies are also found closer to their filament, while active star-forming galaxies statistically lie further away. The contributions of nodes and local density are removed from these gradients to highlight the specific role played by the geometry of the filaments. We find that the measured signal does persist after this removal, clearly demonstrating that proximity to a filament is not equivalent to proximity to an overdensity. These findings are in agreement with gradients measured in both 2D and 3D in the Horizon-AGN simulation and those observed in the spectroscopic surveys VIPERS and GAMA (which both rely on the identification of 3D filaments). They are consistent with a picture in which the influence of the geometry of the large-scale environment drives anisotropic tides that impact the assembly history of galaxies, and hence their observed properties. [ABSTRACT FROM AUTHOR]

The role of the cosmic web in shaping galaxy properties is investigated in the Galaxy And Mass Assembly (GAMA) spectroscopic survey in the redshift range 0.03 ≤ z ≤ 0.25. The stellar mass, u - r dust corrected colour and specific star formation rate (sSFR) of galaxies are analysed as a function of their distances to the 3Dcosmic web features, such as nodes, filaments and walls, as reconstructed by DisPerSE. Significant mass and type/colour gradients are found for the whole population, with more massive and/or passive galaxies being located closer to the filament and wall than their less massive and/or star-forming counterparts. Mass segregation persists among the star-forming population alone. The red fraction of galaxies increases when closing in on nodes, and on filaments regardless of the distance to nodes. Similarly, the starforming population reddens (or lowers its sSFR) at fixed mass when closing in on filament, implying that some quenching takes place. These trends are also found in the state-of-the-art hydrodynamical simulation HORIZON-AGN. These results suggest that on top of stellar mass and large-scale density, the traceless component of the tides from the anisotropic large-scale environment also shapes galactic properties. An extension of excursion theory accounting for filamentary tides provides a qualitative explanation in terms of anisotropic assembly bias: at a given mass, the accretion rate varies with the orientation and distance to filaments. It also explains the absence of type/colour gradients in the data on smaller, non-linear scales. [ABSTRACT FROM AUTHOR]

We present the first quantitative detection of large-scale filamentary structure at z ≃ 0.7 in the large cosmological volume probed by the VIMOS Public Extragalactic Redshift Survey (VIPERS).We use simulations to show the capability of VIPERS to recover robust topological features in the galaxy distribution, in particular the filamentary network. We then investigate how galaxies with different stellar masses and stellar activities are distributed around the filaments, and find a significant segregation, with the most massive or quiescent galaxies being closer to the filament axis than less massive or active galaxies. The signal persists even after downweighting the contribution of peak regions. Our results suggest that massive and quiescent galaxies assemble their stellar mass through successive mergers during their migration along filaments towards the nodes of the cosmic web. On the other hand, low-mass star-forming galaxies prefer the outer edge of filaments, a vorticity-rich region dominated by smooth accretion, as predicted by the recent spin alignment theory. This emphasizes the role of large-scale cosmic flows in shaping galaxy properties. [ABSTRACT FROM AUTHOR]

Background: In patients with colorectal liver metastases (CLM) R0 resection significantly improves overall survival (OS).Methods: In this report, we present the results of a phase II trial of FOLFOX6+bevacizumab in patients with non-optimally resectable CLM. Patients received six cycles of FOLFOX6+ five of bevacizumab. Patients not achieving resectability received six additional cycles of each. A PET-CT was performed at baseline and again within 1 month after initiating treatment.Results: From September 2005 to July 2009, 21 patients were enrolled (Male/Female: 15/6; median age: 65 years). An objective response (OR) was documented in 12 cases (57.1%; complete responses (CRs): 3, partial response (PR): 9); one patient died from toxicity before surgery. Thirteen patients underwent radical surgery (61.9%). Three (23%) had a pathological CR (pCR). Six patients (46.1%) experienced minor postsurgical complications. After a median 38.8-month follow-up, the median OS was 22.5 months. Patients achieving at least 1 unit reduction in Standard uptake value (SUV)max on PET-CT had longer progression-free survival (PFS) (median PFS: 22 vs 14 months, P=0.001).Conclusions: FOLFOX6+bevacizumab does not increase postsurgical complications, yields high rates of resectability and pCR. Early changes in PET-CT seem to be predictive of longer PFS. [ABSTRACT FROM AUTHOR]

Background: Advanced biliary tract carcinoma has a very poor prognosis, with chemotherapy being the mainstay of treatment. Sorafenib, a multikinase inhibitor of VEGFR-2/-3, PDGFR-beta, B-Raf, and C-Raf, has shown to be active in preclinical models of cholangiocarcinoma.Methods: We conducted a phase II trial of single-agent sorafenib in patients with advanced biliary tract carcinoma. Sorafenib was administered at a dose of 400 mg twice a day. The primary end point was the disease control rate at 12 weeks.Results: A total of 46 patients were treated. In all, 26 (56%) had received chemotherapy earlier, and 36 patients completed at least 45 days of treatment. In intention-to-treat analysis, the objective response was 2% and the disease control rate at 12 weeks was 32.6%. Progression-free survival (PFS) was 2.3 months (range: 0-12 months), and the median overall survival was 4.4 months (range: 0-22 months). Performance status was significantly related to PFS: median PFS values for ECOG 0 and 1 were 5.7 and 2.1 months, respectively (P=0.0002). The most common toxicities were skin rash (35%) and fatigue (33%), requiring a dose reduction in 22% of patients.Conclusions: Sorafenib as a single agent has a low activity in cholangiocarcinoma. Patients having a good performance status have a better PFS. The toxicity profile is manageable. [ABSTRACT FROM AUTHOR]

We investigate the effect of the environment on the Faber-Jackson (FJ) relation, using a sample of 384 nearby elliptical galaxies and estimating objectively their environment on the typical scale of galaxy clusters. We show that the intrinsic scatter of the FJ relation is significantly reduced when ellipticals in high-density environments are compared to ellipticals in low-density ones. This result, which holds in a limited range of overdensities, is likely to provide an important observational link between scaling relations and formation mechanisms in galaxies. [ABSTRACT FROM AUTHOR]

Objective: No-visitor policies adopted to prevent coronavirus disease-19 (COVID-19) spread in hospital wards have deeply impacted communication with patients and their relatives. Whereas in pre-COVID-19 era family-clinician meetings were held in person, during the pandemic interactions often took place over the phone, frequently causing feelings of uncertainty and distress to the close ones at home. The goal of this study was to assess and improve the effectiveness of structured telephone-based communication with hospitalized onco-hematological patients' relatives in COVID-19 era., Methods: After no-visitor policy was adopted in the Onco-Hematological Unit of Modena, inpatients' relatives were contacted daily for clinical updates. After discharge, a telephone satisfaction survey was administered to all contact people of patients consecutive admitted between December 2020 and January 2021 (n = 97). Mean score of response and potential statistically significative differences depending on respondents' characteristics were assessed., Results: Most relatives were satisfied with the communication received with a mean total score of 4.69 on a 5-point Likert scale (standard deviation: 0.60). Results showed high satisfaction rate with both the informative (mean ± SD: 4.66 ± 0.64) and emotional (mean ± SD: 4.66 ± 0.58) content, with no significant difference depending on respondents' demographic characteristics (p > 0.05)., Conclusion: A structured telephone-based communication may be a reasonable substitute for face-to-face meetings; especially if regular in time, conducted by the same doctor and integrated with video calls. Our findings might assist health workers in implementing measures to minimize the psychological effects of no-visitor policies during hospitalization. Clinical updates delivery through structured phone calls and video calls could become an opportunity also in post-COVID era., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

The production of recombinant proteins is an essential tool for the expansion of modern biological research and biotechnology. The expression of heterologous proteins in Escherichia coli often results in an incomplete folding process that leads to the accumulation of inclusion bodies (IB), aggregates that hold a certain degree of native-like secondary structure. High hydrostatic pressure (HHP) impairs intermolecular hydrophobic and electrostatic interactions, leading to dissociation of aggregates under non-denaturing conditions and is therefore a useful tool to solubilize proteins for posterior refolding. Cholera toxin (CT) is composed of a non-toxic pentamer of B subunits (CTB), a useful adjuvant in vaccines, and a toxic subunit A (CTA). We studied the process of refolding of CTB using HHP. HHP was shown to be effective for dissociation of CTB monomers from IB. Posterior incubation at atmospheric pressure of concentrated CTB (1mg/ml) is necessary for the association of the monomers. Pentameric CTB was obtained when suspensions of CTB IB were compressed at 2.4kbar for 16h in the presence of Tween 20 and incubated at 1bar for 120h. Soluble and biologically active pentameric CTB was obtained, with a yield of 213mg CTB/liter of culture. The experience gained in this study can be important to improve the refolding of proteins with quaternary structure., (Copyright © 2013 Elsevier B.V. All rights reserved.)

The role of carcinoembryonic antigen (CEA), magnetic resonance imaging (MRI), and positron emission tomography (PET)-computed tomography (CT) in detection of local recurrence of colorectal cancer is evaluated in 71 patients, selected due to suspected relapse at CT follow-up. Recurrence was confirmed by histology in 18 cases and excluded in 25 cases. Sensitivity, specificity, positive and negative predictive values, and accuracy were as follows: 44.4%, 92.5%, 66.7%, 83.1%, and 80.3% for CEA; 88.9%, 73.6%, 53.3%, 95.1%, and 77.5% for MRI; and 94.4%, 73.6%, 54.8%, 97.5%, and 78.9% for PET-CT. A diagnostic protocol integrating CEA and dedicated imaging studies is to be advocated., (Copyright © 2011 Elsevier Inc. All rights reserved.)

Endostatin (ES) is a potent inhibitor of angiogenesis and tumor growth. Continuous ES delivery of ES improves the efficacy and potency of the antitumoral therapy. The TheraCyte system is a polytetrafluoroethylene (PTFE) semipermeable membrane macroencapsulation system for implantation of genetically engineered cells specially designed for the in vivo delivery of therapeutic proteins, such as ES, which circumvents the problem of limited half-life and variation in circulating levels. In order to enable neovascularization at the tissues adjacent to the devices prior to ES secretion by the cells inside them, we designed a scheme in which empty TheraCyte devices were preimplanted SC into immunodeficient mice. Only after healing (17 days later) were Chinese hamster ovary cells expressing ES injected into the preimplanted devices. In another model for device implantation, the cells expressing ES where loaded into the immunoisolation devices prior to implantation into the animals, and the TheraCyte were then immediately implanted SC into the mice. Throughout the 2-month study, constant high ES levels of up to 3.7 microg/ml were detected in the plasma of the mice preimplanted with the devices, while lower but also constant levels of ES (up to 2.1 microg/ml plasma) were detected in the mice that had received devices preloaded with the ES-expressing cells. Immunohistochemistry using anti-ES antibody showed reaction within the device and outside it, demonstrating that ES, secreted by the confined recombinant cells, permeated through the membrane and reached the surrounding tissues.

The complete pathological response after primary chemotherapy could represent an important prognostic factor in patients affected by colorectal liver metastases. In recent studies, increasing complete pathological response seems to be correlated with longer overall survival periods and it is recognized as an important prognostic factor in patients treated with pre-operative chemotherapy. The correlation of radiological information on residual neoplastic disease after neoadjuvant treatment, obtained with CT and PET, has to be evaluated; in fact the complete disappearance of liver metastasis on radiological imaging does not always mean a complete disappearance of tumor tissue on histological examination; when it is documented with surgical procedures and confirmed by pathologist's examination, we can consider the complete pathological response. In recent years the addition of monoclonal antibodies to conventional chemotherapy may further increase the proportion of patients referred for surgery; bevacizumab before surgery has been shown to be feasible and safe, although concerns still exist regarding possible post-surgical and wound healing complications or bleeding. The limitation of the radiologic assessment of response as a surrogate for pathological response is even more relevant when antiangiogenic treatments are used. Excellent responses to bevacizumab-containing regimens do occur and referral to surgical oncology is a crucial step for documentation of complete pathological response.

Purpose: Preoperative chemoradiotherapy followed by surgery represents the standard of care for locally advanced rectal cancer (LARC). Cetuximab has proved activity in advanced colorectal cancer, and its incorporation in preoperative treatment may increase tumor downstaging., Methods and Materials: After biopsy and staging, uT3/uT4 N0/+ LARC received single-agent cetuximab in three doses, followed by weekly cetuximab plus 5-fluorouracil (5-FU), concomitantly with RT. Sample size was calculated according to Bryant and Day test, a two-stage design with at least 10 pathologic complete remissions observed in 60 patients (pts) able to complete the treatment plan., Results: Forty pts with LARC were entered: male/female = 34/6; median age: 61 (range, 28-77); 12 uT3N0 Ed(30%); 25 uT3N1 (62%); 3 uT4N1 (8%); all Eastern Cooperative Oncology Group = 0. Thirty-five pts completed neoadjuvant treatment; 5 (12%) withdrew therapy after one cetuximab administration: three for hypersensitivity reactions, one for rapid progression, and one for purulent arthritis. They continued 5-FU in continuous infusion in association with RT. Thirty-one pts (77%) presented with acnelike rash; dose reduction/interruption of treatment was necessary in six pts (15%): two for Grade 3 acnelike rash, two for Grade 3 gastrointestinal toxicity, and two for refusal. Thirty-eight pts were evaluable for pathological response (one patient refused surgery, and one was progressed during neoadjuvant treatment). Pathological staging was: pT0N0 three pts (8%), pT1N0 1 pt (3%); pT2N0 13 pts (34%), and pT3 19 pts (50%) (N0:9, N1:5; N2:5); pT4 2 pts (5%)., Conclusions: Preoperative treatment with 5-FU, cetuximab, and pelvic RT is feasible with acceptable toxicities; however, the rate of pathologic responses is disappointingly low.