1. Acquired cystic kidney disease: an under-recognized condition in children with end-stage renal disease.
- Author
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Chan, Eugene Y. H. and Warady, Bradley A.
- Subjects
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CHRONIC kidney failure , *DIFFERENTIAL diagnosis , *CYSTIC kidney disease , *DIAGNOSIS - Abstract
Acquired cystic kidney disease (ACKD) is a condition that occurs predominantly in patients with end-stage renal disease (ESRD). In contrast to hereditary cystic kidney disease, ACKD is characterized by the presence of multiple small cysts in bilaterally small kidneys. Limited pediatric data suggest a high incidence (21.6-45.8%) of ACKD in children on dialysis, comparable to that in adults, with an increased frequency associated with a longer duration of dialysis. Recent research has shed light on the pathogenesis of ACKD, such as activation of proto-oncogenes. Although most patients with ACKD are asymptomatic, the condition can be complicated by renal cell carcinoma. Routine surveillance should therefore be considered in at-risk populations. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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