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Metabolic syndrome (MetS) prevalence has augmented globally during recent decades. Over the past years, the consumption of ultra‐processed foods (UPFs) has grown significantly worldwide. So, the present research investigated the association between UPFs and MetS in an Iranian sample. This cross‐sectional research was conducted on people (n = 8841) in the Fasa cohort study, Fars province, Iran. The participants' dietary consumption over a year, UPF consumption, and MetS diagnosis were evaluated through a 125‐item modified food frequency questionnaire, the NOVA food group classification, and the Adult Treatment Panel III of the National Cholesterol Education Program, respectively. The association between the quartiles (Q) of UPF intake and the odds of MetS was estimated using the backward LR method of multivariate analysis. In the multivariate model, after adjusting potential confounders, the association between UPF intake and the odds of MetS was significant (Q4: odds ratio (OR = 3.27; 95% confidence interval (CI): 2.76–3.89). Also, the odds of increasing triglycerides (TG), blood pressure, and fasting blood sugar (FBS) and decreasing high‐density lipoprotein cholesterol (HDL‐C) were significantly higher in the last quartile compared to the first quartile of UPFs (TG: OR = 1.71; 95% CI: 1.49–1.97, blood pressure: OR = 1.53; 95% CI: 1.30–1.79, FBS: OR = 1.30; 95% CI: 1.10–1.54, and HDL‐C: OR = 1.22; 95% CI: 1.08–1.39). The current research found a relationship between UPF intake and MetS and its components, indicating a diet‐containing UPFs can be related to the occurrence of noncommunicable diseases. [ABSTRACT FROM AUTHOR]