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In this paper, we prove the following differential analog of the Noether normalization lemma: for every d-dimensional differential algebraic variety over differentially closed field of zero characteristic there exists a surjective map on to the d-dimensional affine space. Equivalently, for every integral differential algebra A over differential field of zero characteristic there exist differentially independent b1, . . . , bd such that A is differentially algebraic over subalgebra B differentially generated by b1, . . . , bd, and whenever p ⊂ B is a prime differential ideal, there exists a prime differential ideal q ⊂ A such that p = B ∩ q. We also prove the analogous theorem for differential algebraic varieties over the ring of formal power series over an algebraically closed differential field and present some applications to differential equations. [ABSTRACT FROM AUTHOR]