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Objectives: We aim to describe the history of iodine testing of the cervix and identify areas where further work is required.Study Design: We conducted a search of PubMed and Google Scholar. Full article texts were reviewed. Reference lists were screened for additional articles and books. 37 basic articles in journals including ones written in German and three basic articles in books were identified.Results: Glycogen staining of the ectocervical squamous epithelium with iodine goes back to Paul Ehrlich (1854-1915). Walter Schiller (1887-1960) examined nearly 200 different dyes and found that vital staining of the cervical squamous epithelium was best achieved with Lugol's iodine solution, which was indicated by Jean Guillaume Lugol (1786-1851) for disinfection of the vagina. In 1928 W. Lahm observed that the glycogen content of a squamous epithelium cell decreases as anaplasia increases. From the outset, H. Hinselmann included the iodine test in the minimum requirements for colposcopy. In 1946 H. J. Wespi first mentioned the finding of an "uncharacteristic iodine negative area." The first international colposcopic terminology from Graz in 1975 lists the "iodine light area" among the different colposcopy findings. The IFCPC nomenclatures from Rome 1990, Barcelona 2002, and Rio de Janeiro 2011 have evaluated the iodine test and classified their findings differently. A breakthrough to effective cervical cancer screening in resource-limited settings in Africa, India, and Latin America was achieved with R. Sankaranarayanan's publication on naked-eye visual inspection of the cervix after application of Lugol's iodine.Conclusions: This paper is a step toward a better understanding of what we think and do today with iodine testing and what problems and upcoming tasks will arise in future. [ABSTRACT FROM AUTHOR]

Abstract Integrated assessment models are extensively used in the analysis of climate change mitigation and are informing national decision makers as well as contribute to international scientific assessments. This paper conducts a comprehensive review of techno-economic assumptions in the electricity sector among fifteen different global and national integrated assessment models. Particular focus is given to six major economies in the world: Brazil, China, the EU, India, Japan and the US. The comparison reveals that techno-economic characteristics are quite different across integrated assessment models, both for the base year and future years. It is, however, important to recognize that techno-economic assessments from the literature exhibit an equally large range of parameters as the integrated assessment models reviewed. Beyond numerical differences, the representation of technologies also differs among models, which needs to be taken into account when comparing numerical parameters. While desirable, it seems difficult to fully harmonize techno-economic parameters across a broader range of models due to structural differences in the representation of technology. Therefore, making techno-economic parameters available in the future, together with of the technology representation as well as the exact definitions of the parameters should become the standard approach as it allows an open discussion of appropriate assumptions. Highlights • Comparison of technology representation and techno-economic parameters of 15 IAMs. • Structural differences in representing technology in IAMs are identified. • Methods of projecting techno-economic parameters differ across IAMs. • Strict harmonization of techno-economic parameters across models is difficult. • Recommendation to publish techno-economic parameters and technology representation. [ABSTRACT FROM AUTHOR]

• A new implementation of the FP method for storage systems leads to a more accurate objective function evaluation especially in nonlinear cases and to a vectorized unconstrained optimization problem solved many times faster. • FP results as compared to stochastic dynamic programming and novel two-stage stochastic programming results show its overall superiority. • A multi-reservoir application of the FP model is developed with corrective simulations to estimate moments of spillway flows and all other covariance terms. The Fletcher-Ponnambalam (FP) method is an explicit stochastic optimization method for design and operations management of real-world storage systems including surface water reservoir and groundwater management problems. The FP method faces no curse of dimensionality and no need for scenario generation. The paper introduces a novel implementation for the FP method, named FP-2022 here for clarity, by removing the need for nonlinear constraints and by decreasing the number of decision variables to just one third of its original value, significantly reducing solving time (∼27 times faster than the original formulation). Additionally, new expressions derived for the first and second moments of both reservoir release deficit and surplus variables and the already-derived expression for the second moments of reservoir storages are incorporated into the FP-2022 formulation enabling the method to reach an improved optimality for a nonlinear objective function. The enhanced procedure is applied to solving a reservoir operation optimization problem for a major dam in Brazil. The result comparisons made with other methods along with a thorough analysis of release operation policies prove the optimality of this highly numerically efficient and convenient-to-use FP-2022 method. Finally, a multi-reservoir application of the model is also tested with corrective simulations for improved estimates of some additional variables of interest. A specific constraint-handling approach regarding reservoir release lower and upper bounds is also presented. Satisfactory results are obtained for solving the Parambikulam-Aliyar reservoir system, a real world five-reservoir operation optimization problem from India. [ABSTRACT FROM AUTHOR]

This paper compares and contrasts the spread and impact of COVID-19 in the three countries most heavily impacted by the pandemic: the United States (US), India and Brazil. All three of these countries have a federal structure, in which the individual states have largely determined the response to the pandemic. Thus, we perform an extensive analysis of the individual states of these three countries to determine patterns of similarity within each. First, we analyse structural similarity and anomalies in the trajectories of cases and deaths as multivariate time series. Next, we study the lengths of the different waves of the virus outbreaks across the three countries and their states. Finally, we investigate suitable time offsets between cases and deaths as a function of the distinct outbreak waves. In all these analyses, we consistently reveal more characteristically distinct behaviour between US and Indian states, while Brazilian states exhibit less structure in their wave behaviour and changing progression between cases and deaths. • We compare and contrast the natural history of COVID-19 in the US, India and Brazil. • Case, death and mortality rate trajectories are analysed on a state-by-state basis. • We quantify heterogeneity and identify anomalous states therein within each country. • Wave behaviours are explored and clustered across the three countries states. • New mathematical methods quantify the lag in the progression from cases and deaths. [ABSTRACT FROM AUTHOR]

This paper presents international co-inventor networks as both a predictor variable of countries' ability to produce and disseminate internationally green inventions, and an alternative mechanism to support development of relevant programmes and policies in that regard. It includes cases from three developing countries with limited resources for clean technology development, Brazil, India and South Africa, which have shown successes owing to the potentials of co-inventor networks. It contributes the extent literature on this topic, which predominantly emphasizes firms' responses to conventional governments' interventions (subsidies, market price, standards, and interagency cooperation) to achieve cleaner production plans and particularly the Targets 17.6; 17.7 and 17.8 of the sustainable development goals. Broadly, such targets aim at enhancing countries' technological capabilities through partnership. The paper finds various correlations between co-inventor networks and growth of patents in solar energy, air pollution management and biofuels in the sample countries. Correlations are linear in India, followed by Brazil owing to the larger sizes of co-inventor networks but nonlinear in South Africa, which has smaller networks. The paper argues that co-inventor networks accelerate transnational exchanges of core human capital, and are fitting predictors of production and flows of green inventions. They are worth adopting in national and transnational industrial and innovation cluster policies globally to support sustainable production plans. [ABSTRACT FROM AUTHOR]

The research into bioactive natural products originating from medicinal plants, fungi and other organisms has a long history, accumulating abundant and diverse publications. However no quantitative literature analysis has been conducted so far. Here we analyze the bibliometric data of ethnopharmacology literature and relate the semantic content to the publication and citation data so that the major research themes, contributors, and journals of different time periods could be identified and evaluated. Web of Science (WoS) was searched to identify relevant publications. The Analyze function of WoS and bibliometric software (VOSviewer) were utilized to perform the analyses. Until the end of November 2018, 59,576 publications -linked to 'ethnopharmacology' indexed by WoS, published since 1958 in more than 5600 journals, and contributed by over 20,600 institutions located in more than 200 countries/regions, were identified. The papers were published under four dominating WoS categories, namely pharmacology/pharmacy (34.4%), plant sciences (28.6%), medicinal chemistry (25.3%), and integrative complementary medicine (20.6%). India (14.6%) and China (13.2%) were dominating the publication space. The United States and Brazil also had more than 8.0% contribution each. The rest of the top ten countries/regions were mainly from Asia. There were around ten-fold more original articles (84.6%) than reviews (8.4%). Ethnopharmacological research has a consistent focus on food and plant sciences, (bio)chemistry, complementary medicine and pharmacology, with a more limited scientific acceptance in the socio-cultural sciences. Dynamic global contributions have been shifting from developed countries to economically and scientifically emerging countries in Asia, South America and the Middle East. Research on recording medicinal plant species used by traditional medicine continues, but the evaluation of specific properties or treatment effects of extracts and compounds has increased enormously. Moreover increasing attention is paid to some widely distributed natural products, such as curcumin, quercetin, and rutin. Image 1 [ABSTRACT FROM AUTHOR]