1. Immunologic profile of excessive body weight
- Author
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Fatemeh Saberi Hosnijeh, Mansour T. A. Sharabiani, Carlotta Sacerdote, Rosario Tumino, Salvatore Panico, Domenico Palli, Paolo Chiodini, Liliana Minelli, Paolo Vineis, Vittorio Krogh, Chiara Scoccianti, Roel Vermeulen, AZAR SHARABIANI, Mt, Vermeulen, R, Scoccianti, C, Hosnijeh, F, Minelli, L, Sacerdote, C, Palli, D, Krogh, V, Tumino, R, Chiodini, Paolo, Panico, S, Vineis, P., Azar Sharabiani, Mt, Chiodini, P, and Panico, Salvatore
- Subjects
Male ,Oncology ,medicine.medical_specialty ,Multivariate analysis ,Health, Toxicology and Mutagenesis ,Immunology ,Clinical Biochemistry ,030204 cardiovascular system & hematology ,Overweight ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Multivariate analysis of variance ,Internal medicine ,Obesity ,biomarker ,epidemiology ,Epidemiology ,medicine ,Humans ,030212 general & internal medicine ,Biological markers ,Receiver operating characteristic ,business.industry ,Body Weight ,Case-control study ,Middle Aged ,Intercellular Adhesion Molecule-1 ,medicine.disease ,3. Good health ,Logistic Models ,ROC Curve ,Case-Control Studies ,Multivariate Analysis ,Cytokines ,Biomarker (medicine) ,Female ,Chemokines ,medicine.symptom ,business ,Biomarkers - Abstract
The purpose of this paper is to identify immunologic hallmarks of excessive bodyweight. The analysis is based on 176 adults (106 women, 70 men) who participated in a nested case-control study in Italy. All participants were healthy at the time of blood collection and aged between 36 and 75 years. We employed multivariate analysis of variance and a nonparametric Bayesian additive regression tree approach along with a receiver operating characteristic (ROC) curve analysis to determine the immunologic signature of excessive body weight (i.e., obesity and overweight). Interleukin 8 (IL-8), IL-10, interferon γ, and inducible protein 10 were shown to be predictive of excessive body weight with an area under the ROC curve of 71% (p
- Published
- 2011