1. [Diarrhoea and malabsorption due to olmesartan use].
- Author
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van Beurden YH, Nijeboer P, Janssen J, Verbeek WH, and Mulder CJ
- Subjects
- Antihypertensive Agents therapeutic use, Celiac Disease diagnosis, Diagnosis, Differential, Diarrhea diagnosis, Humans, Hypertension drug therapy, Imidazoles therapeutic use, Male, Middle Aged, Netherlands, Olmesartan Medoxomil, Tetrazoles therapeutic use, Antihypertensive Agents adverse effects, Atrophy chemically induced, Diarrhea chemically induced, Imidazoles adverse effects, Tetrazoles adverse effects
- Abstract
Background: The differential diagnosis of diarrhoea in combination with villous atrophy is broad. Coeliac disease heads the list but medication-induced villous atrophy should also be taken into consideration., Case Description: We report the case of a 63-year-old man presenting with recurrent secretory diarrhoea, acute renal failure and metabolic acidosis. Initial work-up revealed total villous atrophy (Marsh stage IIIC) with intraepithelial lymphocytosis. A gluten-free diet did not have any effect on the diarrhoea. During several periods of hospitalization antihypertensive medications were temporarily stopped due to dehydration; this resulted in reduction of his symptoms. Eventually an association between the enteropathy and the antihypertensive olmesartan was suspected. Indeed, permanent withdrawal of olmesartan resulted in permanent clinical improvement., Conclusion: Olmesartan is frequently prescribed in the Netherlands and it should be included in the differential diagnosis of diarrhoea accompanying villous atrophy.
- Published
- 2014