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An amoebic liver abscess, amoebic dysentery and asymptomatic cyst passage were diagnosed in a father, a mother and one of their three children, respectively. One of the other children had been in the tropics, but only after the father's symptoms had begun. All three family members were infected with the same strain of Entamoeba histolytica as determined by polymerase chain reaction (PCR)-based DNA typing. The source of infection was most probably in Southern Italy where the family regularly spent their summer holidays. All three infected patients recovered after drug treatment. In a patient with a liver abscess or colitis, amoebiasis should be considered even in the absence of a history of a stay in the tropics. Stool samples should be examined for amoebic cysts and trophozoites. PCR analysis of parasite DNA extracted directly from stool samples makes differentiation between the morphologically identical cysts of E. histolytica and the non-pathogenic Entamoeba dispar possible. In addition, serum antibodies to E. histolytica are almost always present in symptomatic patients. Invasive infections with E. histolytica require treatment with a tissue amoebicidal drug, followed by a contact amoebicide to prevent recurrence. Currently, paromomycin is considered to be the first-line luminal amoebicide because of its efficacy and safety