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Your search keyword '"Jobsen, Jan J."' showing total 3 results
Start Over Author "Jobsen, Jan J." Language dutch; flemish
3 results on '"Jobsen, Jan J."'

2. Borstsparende therapie en mastectomie vergeleken : Over leving na borstkanker in een vroeg stadium

Author

Van Maaren, Marissa C., De Munck, Linda, De Bock, G. H Truuske, Jobsen, Jan J., Dalen, Thijs, Linn, Sabine C., Poortmans, Philip M., Strobbe, Luc J A, and Siesling, Sabine

Subjects
Medicine(all)
Abstract

Background Investigators of registry-based studies report improved survival for breast-conserving surgery plus radiotherapy compared with mastectomy in early breast cancer. As these studies did not present long-term overall and breast cancer-specific survival, the effect of breast-conserving surgery plus radiotherapy might be overestimated. In this study, we aimed to evaluate 10 year overall and breast cancer-specific survival after breast-conserving surgery plus radiotherapy compared with mastectomy in Dutch women with early breast cancer. Methods In this population-based study, we selected all women from the Netherlands Cancer Registry diagnosed with primary, invasive, stage T12, N01, M0 breast cancer between Jan 1, 2000, and Dec 31, 2004, given either breast-conserving surgery plus radiotherapy or mastectomy, irrespective of axillary staging or dissection or use of adjuvant systemic therapy. Primary outcomes were 10 year overall survival in the entire cohort and breast cancer-specific survival in a representative subcohort of patients diagnosed in 2003 with characteristics similar to the entire cohort. We estimated breast cancer-specific survival by calculating distant metastasis-free and relative survival for every tumour and nodal category. We did multivariable Cox proportional hazard analysis to estimate hazardratios (HRs) for overall and distant metastasis-free survival. We estimated relative survival by calculating excess mortality ratios using life tables of the general population. We did multiple imputation to account for missing data. Findings Of the 37 207 patients included in this study, 21 734 (58%) received breast-conserving surgery plus radiotherapy and 15 473 (42%) received mastectomy. The 2003 representative subcohort consisted of 7552 (20%) patients, of whom 4647 (62%) received breastconserving surgery plus radiotherapy and 2905 (38%) received mastectomy. For both unadjusted and adjusted analysis accounting for various confounding factors, breastconserving surgery plus radiotherapy was significantly associated with improved 10 year overall survival in the whole cohort overall compared with mastectomy (HR 0•51 [95% CI 0•490•53]; p

Published
2016

3. [Trends in the use of primary radiotherapy for cancer in the Netherlands in patients with breast, prostate, rectal and lung tumours].

Author

Struikmans H, Aarts MJ, Jobsen JJ, Koning CC, Poortmans PM, Louwman MW, and Coebergh JW

Subjects
Breast Neoplasms surgery, Female, Humans, Male, Mastectomy, Segmental trends, Netherlands, Practice Guidelines as Topic, Registries, Retrospective Studies, Breast Neoplasms radiotherapy, Lung Neoplasms radiotherapy, Prostatic Neoplasms radiotherapy, Radiotherapy trends, Rectal Neoplasms radiotherapy
Abstract

Objective: To provide insight in the application of radiotherapy as part of primary treatment of patients with cancer in the Netherlands., Design: Retrospective, descriptive population-based study., Method: Data concerning patients with breast, prostate, rectal and non-small cell lung cancer were selected from the Netherlands Cancer Registry in 4 regions, covering 50% of the Dutch population. The selection concerned data from 1997-2008 and, except for prostate cancer, only patients without distant metastases were included., Results: Between 1997 and 2008, the use of primary external radiotherapy increased approximately 7% in breast cancer patients and approximately 30% in rectal cancer patients. In the latter group preoperative radiotherapy strongly increased, while postoperative radiotherapy decreased. For prostate cancer there was an increase in brachytherapy (9%). The use of external beam radiotherapy in patients with prostate cancer and non-small cell lung cancer remained the same. Regional differences in the extent of use of radiotherapy for breast and rectal cancer clearly decreased. These differences remained limited for external beam radiotherapy in prostate and non-small cell lung cancer. Older patients less often received radiotherapy., Conclusion: The increase in use of radiotherapy for breast cancer is explained by the increase in breast conserving surgery. The trends in use in patients with rectal cancer and breast cancer are presumably related to the implementation of multidisciplinary practice guidelines. The implementation of these guidelines probably also contributed to the decrease in regional differences in the use of radiotherapy.

Published
2012

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