1. [Heat stroke: pathophysiology and pathogenesis].
- Author
-
Emonts M and Meinders AE
- Subjects
- Acute Kidney Injury physiopathology, Heat Stroke metabolism, Heat Stroke pathology, Humans, Liver Failure, Acute physiopathology, Models, Biological, Multiple Organ Failure physiopathology, Physical Exertion, Rhabdomyolysis physiopathology, Sodium-Potassium-Exchanging ATPase, Heat Stroke physiopathology
- Abstract
The pathophysiology of heat stroke is not fully understood. Endotoxins and cytokines appear to play a major part in the central nervous system and in the peripheral tissues. Use of specific receptor blockers prior to heat exposure can diminish cerebral damage in animal experiments. The energy depletion model of Hubbard gives a possible explanation for the rhabdomyolysis observed in some heat stroke patients. Failure of the ATP dependent Na(+)-K+ pump is essential in this theory.
- Published
- 2000