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Vanaf 25 mei 2018 is de General Data Protection Regulation (GDPR) van toepassing in alle lidstaten van de Europese Unie. Hoewel organisaties moeten kunnen aantonen dat zij aan de GDPR voldoen, zijn er momenteel geen meetinstrumenten beschikbaar om de maturity (volwassenheid) van eenorganisatie op het gebied van de GDPR objectief te meten. In dit onderzoek is daarom een GDPR maturity model ontwikkeld op basis van bestaande modellen binnen enterprise architectuur (EA) en datamanagement (DM) om de maturity op het gebied van de GDPR te meten. Qua EA is gebruikgemaakt van het GOA 2.0 en OMB EA 3.1, qua DM is gebruikgemaakt van de MD3M, DCAM en DMM-modellen. Het maturity model is in de praktijk toegepast en daarna inhoudelijk en praktisch geëvalueerd op basis van de input van vier experts bij twee grote publieke organisaties, met respectievelijk 3.000 en 58.000 medewerkers. Het maturity model maakt het mogelijk om de mate waarin wordt voldaan aan de GDPR vast te stellen op basis van gestructureerde interviews. Hierbijworden er aspecten uit EA en DM meegewogen waardoor het model een bredere inkijk biedt dan sec de GDPR. Het GDPR maturity model maakt het mogelijk om de maturity, de mate waarin wordt voldaan aan de GDPR, vast te stellen op basis van gestructureerde interviews.

Het doel van de hier gepresenteerde studie is om nader onderzoek te doen naar de waarde van wonen aan water en specifiek te kijken naar de toegevoegde waarde van ecologische waterkwaliteit en natuurvriendelijke oevers in huizenprijzen. Hiertoe is een internetenquête ontwikkeld waarin woningzoekenden een aantal keren worden gevraagd te kiezen tussen een tweetal identieke huizen, die alleen van elkaar verschillen wat betreft de aanwezigheid en kwaliteit van water in de buurt. Achtergrondrapport voor de ex ante evaluatie kaderrichtlijn water (KRW)

Principal component analysis, also called essential dynamics, is a powerful tool for finding global, correlated motions in atomic simulations of macromolecules. It has become an established technique for analyzing molecular dynamics simulations of proteins. The first few principal components of simulations of large proteins often resemble cosines. We derive the principal components for high-dimensional random diffusion, which are almost perfect cosines. This resemblance between protein simulations and noise implies that for many proteins the time scales of current simulations are too short to obtain convergence of collective motions.

A previously healthy boy aged 14 developed persistent ventricular tachycardia while engaged in sports; ultrasonography revealed arrhythmogenic right ventricular dysplasia (ARVD). He was treated with a class III antiarrhythmic drug but nevertheless died 4 years later during recreational activities. An uncle of the boy was found to have died suddenly on a playing field, 25 years previously at the age of 20. In ARVD, fibrolipomatous areas in the right ventricle lead to dilations of the wall where (sometimes fatal) re-entrant tachycardias may develop. An autosomal dominant heredity with variable expression and penetrance is considered probable, while the genetic defect was located recently. Examination and, if necessary, pharmacotherapy of relatives of an ARVD patient may reduce the risk of a fatal arrhythmia.

A previously healthy boy aged 14 developed persistent ventricular tachycardia while engaged in sports; ultrasonography revealed arrhythmogenic right ventricular dysplasia (ARVD). He was treated with a class III antiarrhythmic drug but nevertheless died 4 years later during recreational activities. An uncle of the boy was found to have died suddenly on a playing field, 25 years previously at the age of 20. In ARVD, fibrolipomatous areas in the right ventricle lead to dilations of the wall where (sometimes fatal) re-entrant tachycardias may develop. An autosomal dominant heredity with variable expression and penetrance is considered probable, while the genetic defect was located recently. Examination and, if necessary, pharmacotherapy of relatives of an ARVD patient may reduce the risk of a fatal arrhythmia.

National data were provided on consultations (first, repeat) and prescriptions in patients having ambulatory care for asthma and COPD combined, by age group (0-4, 5-11, and 12-19 yr) and doctor's category (GP, specialist) over the period 1981-1990. Prescriptions were subdivided into (1) beta 2-agonists, anticholinergics, ketotifen, methylxanthines, cromoglycate, inhaled steroids, oral steroids, (2) antibiotics, (3) other drugs. Age specific rates/1000 persons/year were calculated. Rates for first consultations remained steady, pointing to a stable incidence. Rates for repeat consultations increased in the 0-4 yr age group (GP and specialist) and the 5-11 yr age group (specialist). Prescription rates for the pulmonary medication group also rose in particular in these two age groups. For the GP, however, they were counterbalanced by decreasing trends in prescriptions of the 'other drugs', pointing to a shift towards more rational treatment. The increased ratios of prescription rate to consultation rate, not only for the anti-inflammatory drugs but for the bronchodilators as well, especially in the specialist category, suggest an increased morbidity (severity) from obstructive airways disease in childhood.

National hospital admission frequencies were analysed for asthma (ICD-9 code 493), acute bronchi(oli)tis (ICD-code 466), pneumonia and influenza (ICD-code 480-487), and chronic obstructive pulmonary disease (ICD-code 490-492 and 496) for 1980-1989 by sex and according to age (0-4 years, 5-9 years, and 10-14 years). Rates per million of the childhood population per year were calculated and time trend analyses performed by least squares regression. In the age group 0-4 years the admission rates for the respiratory diseases were highest and a general tendency towards increasing rates was present, and significant trends were found for asthma and acute bronchi(oli)tis. In the age groups 5-9 years and 10-14 years the admissions rates were considerably lower and fluctuated with no trends to point to except for a significant increasing trend for acute bronchitis in girls aged 5-9 years and a significant decreasing trend for asthma in boys aged 10-14 years. From the presented data it can be concluded that in childhood the health issue with respect to the respiratory diseases concerns the very young in particular.

National hospital admission frequencies were analysed for asthma (ICD-9 code 493) and chronic obstructive pulmonary disease (COPD) (ICD-code 490 + 491 + 492 + 496) for 1980-1988 by sex and according to age (0-4, 5-34, 35-64, and greater than or equal to 65 years). Rates per million of the population per year were calculated and time trend analyses performed by least square regression. The admission rate for asthma showed a decrease in the total male and female population, as was the case in all age groups, except for the age group 0-4 years in which a significant increase was found. For COPD an increase was observed in total admissions in males and females, due to a substantial increase in the age group greater than or equal to 65 years, while in females the increase in the age group 35-64 years also contributed. The striking increase in hospitalisation for asthma in young children needs further attention, as does the increase in hospital admissions for COPD in older people, particularly with respect to women, for whom continuing rising trends can be expected.

Experience gained with non-surgical catheter occlusion of patent ductus arteriosus in 50 patients (1-65 years) is described. Embolisation of the Rashkind device into the right pulmonary artery occurred in 1 patient. In another patient the device was removed because the prongs of the proximal umbrella could not be visualized. In 4 patients a considerable residual shunt was successfully treated with implantation of a second device. In 1 of these 4 patients this resulted in disappearance of considerable haemolysis as well. Five patients, however, still have a--haemodynamically insignificant--residual shunt. In 43 patients catheter occlusion of the ductus arteriosus was 100% successful. The advantages and disadvantages of this method are briefly compared with those of surgical treatment.

Myocardial infarction is rarely described in the newborn. We report a case in which the newborn had a normal heart and probably normal coronary arteries. The only presenting sign was transient extrasystolic beats. The course was uneventful and our patient recovered spontaneously. A review of the literature is presented.

The Phadiatop test, a new in-vitro test for inhalant allergy, was evaluated in relation to a RAST panel, and in comparison with total IgE. In 248 patients, aged 12-64 years, who had been prescribed pulmonary medication in general practice, the Phadiatop, total IgE (PRIST), and specific IgE (RAST) test were carried out with seven inhalant allergens common in the Netherlands. RAST was considered positive at class greater than or equal to 2 and total IgE elevated at values greater than or equal to 200, greater than or equal to 150, and greater than or equal to 100 kU/l in age groups 12-14, 15-16, and 17-64 years respectively. The result of the Phadiatop test is given as positive or negative. The predictive value of the Phadiatop test for one or more positive RAST results was 100% and its predictive value for all RAST results being negative was 97.1%, while these predictive values for total IgE were 84.7% and 71.2% respectively. It is concluded that the Phadiatop test is a valuable test to confirm or exclude sensitization to common inhalant allergens.

Nederland en Duitsland maakten na afloop van de Eerste Wereldoorlog kennis met moderne dansen en jazzmuziek uit de Verenigde Staten. De negatieve respons van de gevestigde muziekwereld vond weerklank in andere sectoren van de samenleving: jeugdbeweging, universiteiten, godsdienst en politiek. Morele en politieke argumenten wogen hierbij zwaarder dan de zuiver muzikale kritiek. Deze politisering mondde in Duitsland na 1933 uit in een systematische bestrijding van swing- en jazzmuziek door het nazi-regime. In Nederland hield de overheid zich vooralsnog afzijdig. Na mei 1940 veranderde dat. De door het propagandaministerie van Goebbels en de 'Reichsmusik-kammer' afgekondigde maatregelen moesten ook in Nederland doorgevoerd worden. Musici, journalisten, programmakers en horeca-exploitanten kregen te maken met een stroom van voorschriften en verbodsbepalingen, waarmee de vrijheid van muzikale meningsuiting aan banden werd gelegd. ‘Ongewenschte muziek’ geeft een gedetailleerd beeld van de geschiedenis van de jazz- en amusementsmuziek in Nederland en Duitsland tot 1945.