1. [Ceftriaxone-induced immune haemolytic anaemia and multi-organ failure].
- Author
-
Mulkens CE, van Lochem EG, Folman CC, van der Spek E, and van Leeuwen HJ
- Subjects
- Anemia, Hemolytic immunology, Anti-Bacterial Agents therapeutic use, Ceftriaxone therapeutic use, Female, Fluid Therapy, Glucocorticoids therapeutic use, Humans, Middle Aged, Multiple Organ Failure immunology, Anemia, Hemolytic chemically induced, Anti-Bacterial Agents adverse effects, Ceftriaxone adverse effects, Multiple Organ Failure chemically induced
- Abstract
Background: Drug-induced immune haemolytic anaemia (DIIHA) is caused by various drugs or their metabolites. Cephalosporins are associated with haemolytic anaemia but multi-organ failure is rarely described., Case Description: We report the case of a 57-year-old female who was diagnosed with neuroborreliosis and treated with ceftriaxone. The patient developed severe DIIHA. Massive intravascular haemolysis led to shock and acute renal failure, necessitating mechanical ventilation and dialysis. Treatment with ceftriaxone was discontinued and glucocorticoids were prescribed. The patient recovered slowly but fully., Conclusion: Ceftriaxone-induced immune haemolytic anaemia is a rare but potentially fatal condition.
- Published
- 2015