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Your search keyword '"BENZOXAZINES"' showing total 7 results
Start Over Descriptor "BENZOXAZINES" Language dutch; flemish
7 results on '"BENZOXAZINES"'

1. [The use of the non-nucleoside reverse transcriptase inhibitors nevirapine and efavirenz in the treatment of patients with a chronic HIV-I infection]

Author

F, van Leth and J M, Lange

Subjects
Cyclopropanes, Treatment Outcome, Anti-HIV Agents, Alkynes, Antiretroviral Therapy, Highly Active, Drug Resistance, Viral, Oxazines, HIV-1, Humans, Reverse Transcriptase Inhibitors, HIV Infections, Nevirapine, Benzoxazines
Abstract

The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are an important group ofantiretroviral drugs in the treatment of a chronic HIV-I infection. The risk of viral resistance to NNRTIs is strongly diminished when they are used as part of a highly active antiretroviral combination therapy (HAART). Randomised trials have shown that nevirapine and efavirenz have a comparable antiretroviral efficacy. While rash and hepatotoxicity are associated with the use of nevirapine, the use of efavirenz is associated with neuropsychiatric abnormalities. The increase in HDL-cholesterol, which may be associated with a lower risk of cardiovascular disease, is greater with nevirapine than with efavirenz. The choice between the two drugs can be tailored to the needs of the patient. The rapid selection ofNNRTI-resistant HIV-I strains during the sub-optimal use of nevirapine and efavirenz demands the development of new NNRTIs.

Published
2006

3. [Severe psychosis in an African woman due to the antiretroviral agent efavirenz]

Author

G, van Twillert, G, van Santen, and M H, Godfried

Subjects
Adult, Cyclopropanes, Anti-HIV Agents, Metabolic Clearance Rate, Black People, HIV Infections, Ghana, Benzoxazines, Psychotic Disorders, Alkynes, Oxazines, Humans, Female, Netherlands
Abstract

A 34-year-old woman originally from Ghana was given efavirenz as antiretroviral therapy. One week later she was found to be in a psychotic state with paranoid hallucinations and anxiety; she then stabbed a nurse. The literature indicates that female patients of African origin appear to be more susceptible to the side effects of efavirenz due to genetically reduced clearance and therefore higher serum levels.

Published
2005

4. [The use of the non-nucleoside reverse transcriptase inhibitors nevirapine and efavirenz in the treatment of patients with a chronic HIV-I infection].

Author

van Leth F and Lange JM

Subjects
Alkynes, Anti-HIV Agents adverse effects, Antiretroviral Therapy, Highly Active, Benzoxazines, Cyclopropanes, Drug Resistance, Viral, Humans, Nevirapine adverse effects, Oxazines adverse effects, Reverse Transcriptase Inhibitors adverse effects, Treatment Outcome, Anti-HIV Agents therapeutic use, HIV Infections drug therapy, HIV-1 drug effects, Nevirapine therapeutic use, Oxazines therapeutic use, Reverse Transcriptase Inhibitors therapeutic use
Abstract

The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are an important group ofantiretroviral drugs in the treatment of a chronic HIV-I infection. The risk of viral resistance to NNRTIs is strongly diminished when they are used as part of a highly active antiretroviral combination therapy (HAART). Randomised trials have shown that nevirapine and efavirenz have a comparable antiretroviral efficacy. While rash and hepatotoxicity are associated with the use of nevirapine, the use of efavirenz is associated with neuropsychiatric abnormalities. The increase in HDL-cholesterol, which may be associated with a lower risk of cardiovascular disease, is greater with nevirapine than with efavirenz. The choice between the two drugs can be tailored to the needs of the patient. The rapid selection ofNNRTI-resistant HIV-I strains during the sub-optimal use of nevirapine and efavirenz demands the development of new NNRTIs.

Published
2006

5. [Severe psychosis in an African woman due to the antiretroviral agent efavirenz].

Author

Sierink HD and Bloemkolk D

Subjects
Alkynes, Anti-HIV Agents therapeutic use, Benzoxazines, Cyclopropanes, Diagnosis, Differential, HIV Infections drug therapy, Humans, Oxazines therapeutic use, Psychotic Disorders diagnosis, Anti-HIV Agents adverse effects, Black People, Emergency Services, Psychiatric statistics & numerical data, Oxazines adverse effects, Psychotic Disorders etiology
Published
2006

6. [Severe psychosis in an African woman due to the antiretroviral agent efavirenz].

Author

Oudijn MS, Vrijlandt CM, and Casteelen G

Subjects
Alkynes, Anti-HIV Agents therapeutic use, Benzoxazines, Cyclopropanes, Diagnosis, Differential, HIV Infections drug therapy, Humans, Oxazines therapeutic use, Anti-HIV Agents adverse effects, Emergency Services, Psychiatric statistics & numerical data, Oxazines adverse effects, Psychotic Disorders diagnosis, Psychotic Disorders etiology
Published
2006

7. [Severe psychosis in an African woman due to the antiretroviral agent efavirenz].

Author

van Twillert G, van Santen G, and Godfried MH

Subjects
Adult, Alkynes, Anti-HIV Agents pharmacokinetics, Anti-HIV Agents therapeutic use, Benzoxazines, Cyclopropanes, Female, Ghana ethnology, HIV Infections drug therapy, Humans, Metabolic Clearance Rate genetics, Netherlands, Oxazines pharmacokinetics, Oxazines therapeutic use, Psychotic Disorders ethnology, Anti-HIV Agents adverse effects, Black People genetics, Oxazines adverse effects, Psychotic Disorders etiology
Abstract

A 34-year-old woman originally from Ghana was given efavirenz as antiretroviral therapy. One week later she was found to be in a psychotic state with paranoid hallucinations and anxiety; she then stabbed a nurse. The literature indicates that female patients of African origin appear to be more susceptible to the side effects of efavirenz due to genetically reduced clearance and therefore higher serum levels.

Published
2005

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