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Idiopathic intracranial hypertension (IIH) is a challenging disease characterized by an increase in intracranial pressure which occurs without any known cause. The disease is mainly seen in obese females of child-bearing age. While originally described as rare, the incidence is increasing in parallel with pandemic obesity, and clinicians in all fields are increasingly likely to meet patients with IIH. The condition causes major morbidity due to chronic headache and visual loss if untreated. In the past ten years new diagnostic criteria and guidelines for management have been published.

This is a case report of a 29-year-old man, who presented with progressive confusion, memory problems and personality changes during 1.5 months. Later, he developed bilateral hearing impairment but had no visual symptoms. A brain MRI showed numerous small hyperintensities in both hemispheres, a retinal fluorescence angiography revealed multiple hyperfluorescent arterial occlusions, and an audiogram showed bilateral hearing impairment. The patient was treated for Susac syndrome with high-dose corticosteroids initially, followed by intravenous immunoglobulin and cyclophosphamide.

Behçet's disease (BD) is a chronic relapsing inflammatory disorder of unknown aetiology with involvement of multiple organs. The incidence of BD is highest in the countries along the ancient Silk Route. In approximately 9% of the BD patients there is involvement of the central nervous system (CNS). We present a case of a 32 year-old Lebanese woman with severe headache and papilloedema due to a cerebral venous thrombosis and secondary intracranial hypertension. During follow-up she was diagnosed with bilateral uveitis and a history of recidivating oral and genital ulcerations was disclosed. BD with CNS affection is an important diagnosis to keep in mind in case of cerebral venous thrombosis.

Cognitive dysfunction, unexplained deafness or retinal branch artery occlusions in otherwise healthy persons are challenging conditions, in particular when occurring in young adults. Susac's syndrome is characterized by the clinical triad of encephalopathy, hearing loss and retinal branch arterial occlusions affecting mainly young women. Appropriate diagnosis and management requires multidisciplinary management of the disease.