Search

Your search keyword '"Toll-Like Receptors immunology"' showing total 2 results
Start Over Descriptor "Toll-Like Receptors immunology" Language danish
2 results on '"Toll-Like Receptors immunology"'

1. [Danger signals and inflammasomes in autoinflammatory and autoimmune diseases].

Author

Bendtzen K

Subjects
Arteriosclerosis immunology, Arthritis immunology, Cytokines immunology, Diabetes Mellitus, Type 1 immunology, Hereditary Autoinflammatory Diseases immunology, Humans, Immunity, Innate immunology, Nod Signaling Adaptor Proteins immunology, Receptors, Pattern Recognition immunology, Receptors, Tumor Necrosis Factor immunology, Toll-Like Receptors immunology, Autoimmune Diseases immunology, Inflammasomes immunology, Inflammation immunology
Abstract

Cytoplasmic inflammasomes are formed through activation of pattern recognition receptors (PRR) of the innate immune system. Endogenous and exogenous danger signals, e.g. DNA- and RNA-fragments, urate- and cholesterol crystals, silica and asbestos, ß-amyloid, UV-light and skin irritants, may induce NOD-like receptor protein (NLRP)3 inflammasomes. These inflammasomes govern the induction of proinflammatory cytokines such as IL-1ß, IL-18 and IL-33. PRR and inflammasome dysfunctions may underly immunoinflammatory diseases such as gout and other arthritides, type 1 diabetes and arteriosclerosis.

Published
2011

2. [Toll-like receptors, a new way of treatment?].

Author

Pedersen CV, Østergaard LJ, Mogensen TH, Paludan SR, and Bertelsen LS

Subjects
Animals, Bacterial Infections drug therapy, Bacterial Infections etiology, Bacterial Infections immunology, Disaccharides therapeutic use, Humans, Immunity, Innate, Inflammatory Bowel Diseases drug therapy, Inflammatory Bowel Diseases etiology, Inflammatory Bowel Diseases immunology, Shock, Septic drug therapy, Shock, Septic etiology, Shock, Septic immunology, Sugar Phosphates therapeutic use, Virus Diseases drug therapy, Virus Diseases etiology, Virus Diseases immunology, Toll-Like Receptors drug effects, Toll-Like Receptors immunology, Toll-Like Receptors physiology
Abstract

Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The discovery of TLRs has provided a substantial increase in the knowledge of immunologic aspects of disease pathology and is presently giving rise to new treatment strategies. This review summarizes the current knowledge on TLRs functioning in infections, their possible roles in inflammatory bowl disease and the pivotal role for TLRs in endotoxic shock, an area which is currently subject to development of a new farmakon.

Published
2007

Catalog

Books, media, physical & digital resources
See catalog results