1. [Myopathy in a patient during simvastatin and fluconazole treatment].
- Author
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Pedersen JK, Lydolph MC, Somnier F, and Junker P
- Subjects
- Aged, Antifungal Agents administration & dosage, Drug Interactions, Female, Fluconazole administration & dosage, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage, Rhabdomyolysis therapy, Simvastatin administration & dosage, Antifungal Agents adverse effects, Fluconazole adverse effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Rhabdomyolysis chemically induced, Simvastatin adverse effects
- Abstract
A 69-year-old female was admitted due to progressive loss of muscle strength following addition of fluconazole to long-term simvastatin treatment. Rhabdomyolysis was suspected and both drugs were discontinued. Forced diuresis was initiated together with a short course of prednisolone. After 21 weeks the patient had regained normal muscle strength and endurance. The favourable course and the absence of antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase suggest that the condition was due to interaction between the two drugs, which are both metabolized via the CYP3A4 pathway.
- Published
- 2016