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4. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research:Fertility and Sterility

Author

Rahmioglu, Nilufer, Fassbender, Amelie, Vitonis, Allison F., Tworoger, Shelley S., Hummelshoj, Lone, D'Hooghe, Thomas M., Adamson, G. David, Giudice, Linda C., Becker, Christian M., Zondervan, Krina T., Missmer, Stacey A., Adamson, G.D., Allaire, C., Anchan, R., Becker, C.M., Bedaiwy, M.A., Buck Louis, G.M., Calhaz-Jorge, C., Chwalisz, K., D'Hooghe, T.M., Fassbender, A., Faustmann, T., Fazleabas, A.T., Flores, I., Forman, A., Fraser, I., Giudice, L.C., Gotte, M., Gregersen, P., Guo, S.-W., Harada, T., Hartwell, D., Horne, A.W., Hull, M.L., Hummelshoj, L., Ibrahim, M.G., Kiesel, L., Laufer, M.R., Machens, K., Mechsner, S., Missmer, S.A., Montgomery, G.W., Nap, A., Nyegaard, Mette, Osteen, K.G., Petta, C.A., Rahmioglu, N., Renner, S.P., Riedlinger, J., Roehrich, S., Rogers, P.A., Rombauts, L., Salumets, A., Saridogan, E., Seckin, T., Stratton, P., Sharpe-Timms, K.L., Tworoger, S., Vigano, P., Vincent, K., Vitonis, A.F., Wienhues-Thelen, U.-H., Yeung P.P., Jr., Yong, P., and Zondervan, K.T.

Abstract

ObjectiveTo harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of fluid biospecimens relevant to endometriosis.

Published
2014
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5. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research:Fertility and Sterility

Author

Fassbender, Amelie, Rahmioglu, Nilufer, Vitonis, Allison F., Viganò, Paola, Giudice, Linda C., D’Hooghe, Thomas M., Hummelshoj, Lone, Adamson, G. David, Becker, Christian M., Missmer, Stacey A., Zondervan, Krina T., Adamson, G.D., Allaire, C., Anchan, R., Becker, C.M., Bedaiwy, M.A., Buck Louis, G.M., Calhaz-Jorge, C., Chwalisz, K., D'Hooghe, T.M., Fassbender, A., Faustmann, T., Fazleabas, A.T., Flores, I., Forman, A., Fraser, I., Giudice, L.C., Gotte, M., Gregersen, P., Guo, S.-W., Harada, T., Hartwell, D., Horne, A.W., Hull, M.L., Hummelshoj, L., Ibrahim, M.G., Kiesel, L., Laufer, M.R., Machens, K., Mechsner, S., Missmer, S.A., Montgomery, G.W., Nap, A., Nyegaard, Mette, Osteen, K.G., Petta, C.A., Rahmioglu, N., Renner, S.P., Riedlinger, J., Roehrich, S., Rogers, P.A., Rombauts, L., Salumets, A., Saridogan, E., Seckin, T., Stratton, P., Sharpe-Timms, K.L., Tworoger, S., Vigano, P., Vincent, K., Vitonis, A.F., Wienhues-Thelen, U.-H., Yeung P.P., Jr., Yong, P., and Zondervan, K.T.

Abstract

ObjectiveTo harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of human tissues relevant to endometriosis.

Published
2014
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6. World Endometriosis Research Foundation Endometriosis Phenome and biobanking harmonization project: II. Clinical and covariate phenotype data collection in endometriosis research:Fertility and Sterility

Author

Vitonis, Allison F., Vincent, Katy, Rahmioglu, Nilufer, Fassbender, Amelie, Buck Louis, Germaine M., Hummelshoj, Lone, Giudice, Linda C., Stratton, Pamela, Adamson, G. David, Becker, Christian M., Zondervan, Krina T., Missmer, Stacey A., Adamson, G.D., Allaire, C., Anchan, R., Becker, C.M., Bedaiwy, M.A., Buck Louis, G.M., Calhaz-Jorge, C., Chwalisz, K., D'Hooghe, T.M., Fassbender, A., Faustmann, T., Fazleabas, A.T., Flores, I., Forman, A., Fraser, I., Giudice, L.C., Gotte, M., Gregersen, P., Guo, S.-W., Harada, T., Hartwell, D., Horne, A.W., Hull, M.L., Hummelshoj, L., Ibrahim, M.G., Kiesel, L., Laufer, M.R., Machens, K., Mechsner, S., Missmer, S.A., Montgomery, G.W., Nap, A., Nyegaard, Mette, Osteen, K.G., Petta, C.A., Rahmioglu, N., Renner, S.P., Riedlinger, J., Roehrich, S., Rogers, P.A., Rombauts, L., Salumets, A., Saridogan, E., Seckin, T., Stratton, P., Sharpe-Timms, K.L., Tworoger, S., Vigano, P., Vincent, K., Vitonis, A.F., Wienhues-Thelen, U.-H., Yeung P.P., Jr., Yong, P., and Zondervan, K.T.

Abstract

ObjectiveTo harmonize the collection of nonsurgical clinical and epidemiologic data relevant to endometriosis research, allowing large-scale collaboration.

Published
2014
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7. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research:Fertility and Sterility

Author

Becker, Christian M., Laufer, Marc R., Stratton, Pamela, Hummelshoj, Lone, Missmer, Stacey A., Zondervan, Krina T., Adamson, G. David, Adamson, G.D., Allaire, C., Anchan, R., Becker, C.M., Bedaiwy, M.A., Buck Louis, G.M., Calhaz-Jorge, C., Chwalisz, K., D'Hooghe, T.M., Fassbender, A., Faustmann, T., Fazleabas, A.T., Flores, I., Forman, A., Fraser, I., Giudice, L.C., Gotte, M., Gregersen, P., Guo, S.-W., Harada, T., Hartwell, D., Horne, A.W., Hull, M.L., Hummelshoj, L., Ibrahim, M.G., Kiesel, L., Laufer, M.R., Machens, K., Mechsner, S., Missmer, S.A., Montgomery, G.W., Nap, A., Nyegaard, Mette, Osteen, K.G., Petta, C.A., Rahmioglu, N., Renner, S.P., Riedlinger, J., Roehrich, S., Rogers, P.A., Rombauts, L., Salumets, A., Saridogan, E., Seckin, T., Stratton, P., Sharpe-Timms, K.L., Tworoger, S., Vigano, P., Vincent, K., Vitonis, A.F., Wienhues-Thelen, U.-H., Yeung P.P., Jr., Yong, P., and Zondervan, K.T.

Abstract

ObjectiveTo standardize the recording of surgical phenotypic information on endometriosis and related sample collections obtained at laparoscopy, allowing large-scale collaborative research into the condition.

Published
2014
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8. The clinical use of polygenic risk scores.

Author

Terkelsen T, Hansen TF, Herlin MK, Djursby M, Nyegaard M, Pedersen IS, Lildballe DL, Færgeman SL, Sunde L, and Hauberg ME

Subjects
Humans, Risk Factors, Secondary Prevention, Genetic Predisposition to Disease, Genome-Wide Association Study, Genetic Testing, Medicine
Abstract

Polygenic risk scores (PRS) identify at-risk individuals for many common diseases. A discussion of strengths and limitations is carried out in this review. PRS complement traditional genetic testing and have shown utility in establishing a proper diagnosis and guiding primary and secondary prevention. Some individuals with high PRS have risks similar to those with monogenic predisposition. Limitations include potential misinterpretations, problems with application across ancestries, and limited usefulness in low-heritability traits. Despite its shortcomings PRS are predicted to play major roles in the future of personal medicine and genetic testing., (Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Published
2023

9. [The haematological biobank--an infrastructure for quality assurance, development and research].

Author

Johnsen HE, Pilgaard L, Højfeldt AD, Andersson TL, Schmitz A, Gade KH, Fogd K, Nyegaard M, Bøgsted M, and Dybkær K

Subjects
Biomarkers analysis, Biomedical Research ethics, Diffusion of Innovation, Hematologic Neoplasms diagnosis, Hematologic Neoplasms therapy, Humans, International Cooperation, Outcome Assessment, Health Care, Prognosis, Quality Assurance, Health Care, Registries, Retrospective Studies, Specimen Handling methods, Specimen Handling standards, Biological Specimen Banks ethics, Biological Specimen Banks organization & administration, Biological Specimen Banks standards, Hematologic Diseases diagnosis, Hematologic Diseases therapy
Abstract

Archived patient samples of biological material coupled to clinical databases are valuable and hold the potential to improve patient care, quality control, research and development. Biobanks form a catalytic infrastructure which ensures the registration, handling and storage of collected biological material. Here, we describe the Haematology Biobank and stress the significance of a registration database. Together, these form the basis for retrospective validation of clinical progress and prognostic evaluation of new diagnostic methods, which can therefore be more quickly implemented in the clinic.

Published
2011

10. [Cancer stem cells in the haematopoietic system].

Author

Urup T, Madsen G, Hallager S, Schmitz A, Fogd K, Bøgsted M, Nyegaard M, Sørensen KD, and Johnsen HE

Subjects
Animals, Humans, Multiple Myeloma etiology, Multiple Myeloma genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma etiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics, Hematopoietic Stem Cells cytology, Hematopoietic Stem Cells physiology, Multiple Myeloma pathology, Neoplastic Stem Cells pathology, Neoplastic Stem Cells physiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology
Abstract

Cancer is dependent on so-called cancer stem cells that initiate and maintain the cancer cell population. Stem cells are described in normal tissue as low-frequent, self-renewing cells with a multi- or pluripotent differentiation potential. The true characteristics of the cancer-initiating cells are still not entirely known, but it is obvious that identifying these cells will enable us to better understand the biology of cancer. In this article, we focus on normal haematopoietic stem cells and cancer stem cells in leukaemia and multiple myeloma.

Published
2010

11. [Use of translational database at clinical department].

Author

Højfeldt AD, Johnsen HE, Bøgsted M, Schmitz A, Fogd K, Pilgaard L, Nyegaard M, Dybkaer K, and Bukh A

Subjects
Biological Specimen Banks standards, Decision Support Techniques, Gene Expression Profiling, Hematologic Neoplasms diagnosis, Hematologic Neoplasms therapy, Humans, Oligonucleotide Array Sequence Analysis, Prognosis, Protein Biosynthesis, Quality Assurance, Health Care, Systems Integration, Databases as Topic standards, Databases, Genetic standards, Hematologic Neoplasms genetics
Abstract

In haematology it is assumed that integrative analysis of global gene expression, protein and cell profiles as well as clinical data will lead to the development of new diagnostic, prognostic and predictive methods. A translational database system registering and combining all data and clinical observations about the patient is therefore needed. It is expected that along with automated prediction and prognosis tools, such a database system may have the potential to assist the development of new machine-based diagnostic decision-making processes.

Published
2010

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