1. [Legionella pneumonia in patients treated with infliximab].
- Author
-
Vinter H and Nielsen HI
- Subjects
- Anti-Inflammatory Agents adverse effects, Crohn Disease drug therapy, Crohn Disease immunology, Dermatologic Agents adverse effects, Fatal Outcome, Female, Humans, Immunosuppressive Agents adverse effects, Infliximab, Legionella pneumophila isolation & purification, Legionnaires' Disease diagnosis, Legionnaires' Disease immunology, Male, Middle Aged, Psoriasis drug therapy, Psoriasis immunology, Antibodies, Monoclonal adverse effects, Legionnaires' Disease etiology
- Abstract
Therapy with tumour necrosis factor-alfa inhibitors is widely used in various inflammatory disorders, but adverse events from severe infections with intracellular pathogens may occur. We describe two cases of severe pulmonary legionellosis in patients treated with infliximab for Crohn's disease and psoriasis, respectively. We conclude that legionella infections are probably more frequent in patients receiving immunosuppressive therapy with tumour necrosis factor-alfa inhibitors than in the background population.
- Published
- 2009