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Late sequelae to cancer treatment of the pelvic organs are common. Gastrointestinal symptoms including chronic diarrhoea, faecal urgency, and faecal incontinence are some of the most disabling with a negative impact on quality of life. By investigating and treating the gastrointestinal symptoms in specialised late adverse effects clinics more than half of the patients can be helped. The treatment is individually tailored depending on the patients' main symptoms and underlying pathophysiology performed in collaboration between gastroenterologists, surgeons, oncologists, dieticians, and specialised nurses, as argued in this review.

Screening programmes for colorectal cancer (CRC) are being implemented in various countries worldwide including Denmark. The majority of programmes rely on faecal occult blood testing with subsequent colonoscopy. This approach is challenged by limited compliance, which reduces the efficiency of the screening programme. Current research into improve-ments of screening of CRC includes biological markers identified in blood. Combining blood-based biological markers with clinical and demographical parameters have shown promising results, which may improve the present approach to screening.

Danish National Guidelines (DNG) for diagnostic strategy of patients with colorectal cancer (CRC) symptoms are structured to ensure prompt and specific diagnostic testing, thus minimizing treatment delay. DNG state that the function of the general practitioner is to refer patients to a specialist as soon as the patient presents with CRC symptoms. Unfortunately, 60% of CRC patients experience a delay in referrals due to the fact that the guidelines are not followed as exemplified in our two cases.

Introduction: Restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) has become the operation of choice for patients with ulcerative colitis and familial polyposis. However, the procedure is complex with a long learning curve, and carries a risk of both early and late complications. The purpose of this study was to evaluate the early outcomes (within 30 days after surgery) and organisation of IPAA surgery in Denmark between January 2001 and December 2005., Materials and Methods: IPAA patients >18 years old were drawn from the Danish National Patient Registry from 2001 through 2005. Hospital stay and the primary operation were recorded as well as re-operations and readmissions within the first 30 postoperative days. Mortality was recorded from the National Civic Register., Results: 385 patients underwent IPAA surgery during the study period (77/year) in six centres. One centre performed 31% of the operations. The mean postoperative hospital stay (primary - and readmission within 30 days) was 13.5 days. 24% were readmitted within 30 days and 8% were re-operated. The mortality rate was 0.3%., Conclusion: Based upon the limited number of operations, the high risk of early readmissions and re-operations, the well-known steep learning curve and the potential improvement with the technically demanding laparoscopic technique, a reorganisation of the procedure to fewer centres is suggested.

Peritoneal carcinomatosis (PC) is commonly seen in colorectal cancer and is uniformly fatal. Cytoreductive surgery (CS) combined with hyperthermic intraperitoneal chemotherapy (HIIC) is a new treatment in strictly selected patients with PC. CS includes peritonectomy procedures and resection of infiltrated viscera leaving no macroscopic tumor thicker than 2.5 mm behind. Peritoneal perfusion with mitomycin C at a temperature of 40 degrees -41 degrees C is performed at the end of surgery. The postoperative morbidity and mortality rates are 20%-30% and 4%-8% respectively. Median survival is 1-2 years and the 5-year survival is 19%.

A patient with a retained anally introduced colorectal foreign body or complications hereof needs appropriate treatment. The patient may be in danger and is certainly in discomfort. The problem is relatively rare; however, its incidence may be expected to increase. Guidelines for handling of the situation are lacking in many textbooks. Here, a suggestion for handling of a patient with a retained colorectal foreign body or complications hereof is presented.

Recent international data have documented improved postoperative outcome in relation to hospital and surgeon volume. Nation-wide Danish data have documented a high mortality and long hospital stay after abdominal cancer surgery, which is performed in a large number of departments. It is concluded that reorganisation with fewer surgical departments is required to improve outcome after major gastrointestinal surgery.

In relation to the risk of colorectal cancer, the population is divided into high-risk and average-risk groups. Patients at high risk are followed according to the national recommendations. Patients at average risk are examined according to their primary symptom(s). The strategy is based on the diagnostic strategy described in a Danish Health Technology Assessment published in 2001. The article states the recommendations for the high- risk groups and describes the value of the individual primary symptoms of colorectal cancer for average-risk patients and the examinations recommended accordingly.