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Your search keyword '"Ardenkjaer-Larsen, Jan Henrik"' showing total 7 results
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4. Hyperpolarized Singlet State NMR

Author

Pileio, Giuseppe, Brown, Lynda J., Tayler, Michael, Laustsen, Christoffer, Brown, Richard C. D., Ardenkjær-Larsen, Jan Henrik, and Levitt, Malcolm

Published
2012

7. [Quantitative cellular metabolism can be estimated by hyperpolarized magnetic resonance].

Author

Laustsen C, Ardenkjaer-Larsen JH, Pedersen M, Ringgaard S, and Stødkilde-Jørgensen H

Subjects
Administration, Intravenous, Biosensing Techniques, Humans, Lactic Acid administration & dosage, Lactic Acid metabolism, Magnetic Resonance Imaging methods, Male, Prostatic Neoplasms diagnosis, Prostatic Neoplasms metabolism, Pyruvic Acid administration & dosage, Pyruvic Acid metabolism, Magnetic Resonance Spectroscopy methods
Abstract

A new MR methodology, hyperpolarized MR spectroscopy (MRS), enhances the MRS signals by more than a factor 10,000, enabling fast and unique insight into in situ metabolic processes. So far the method has provided new and exciting metabolic details in prostate, heart, brain, kidney and liver examinations. In diseases characterized by abnormal metabolic profiles, such as in diabetes and tumour tissue, hyperpolarized MRS provides highly detailed spatial information as well as quantitative estimates of individual steps in glycolysis and real-time amino acid metabolism.

Published
2014

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