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Copyright of Remedia is the property of Medical Tribune CZ, s.r.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Neurologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Remedia is the property of Medical Tribune CZ, s.r.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Remedia is the property of Medical Tribune CZ, s.r.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Remedia is the property of Medical Tribune CZ, s.r.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Multiple sclerosis is a chronic inflammatory demyelinati ng and neurodegenerative disease affecti ng the CNS. Interferon (IFN) pda 44 gg, dimethyl fumarate (DMF) and fingolimod are established medications for the treatment of relapsing-remitti ng MS (RR MS). The aim of the project (analysis from registry ReMuS) was a comparison of the efficacy of IFN p-1a 44 gg, DMF and fingolimod in patients with RR MS in real world evidence in the Czech Republic. This treatment was started within 90 days after relapse. Patients and methods: A total of 279 patients with RR MS who experienced one relapse during the first line treatment (IFN p-1a 22 gg given 3x weekly, IFN p-1a 30 gg given 1x weekly, IFN p-1b 250 gg given each other day, teriflunomid 14 mg given daily, glatiramer acetate 20 mg given daily or glatiramer acetate given 40 mg given 3x weekly) and who were switched to the treatment with IFN p-1a 44 gg, DMF or fingolimod were included into the study. The observed parameters were annualized relapse rate (ARR), time to next relapse, proportion of relapse free patients and change in Expanded Disability Status Scale (EDSS) at 1-year after treatment. Results: We found out significant improvement in observed outcomes during 1-year observation after treatment change in all particular medications. Comparison of IFN p-1a 44 gg group (83 patients) vs. DMF or fingolimod group (196 patients) showed more significant improvement in observed parameters (ARR and change of EDSS) in DMF or fingolimod group. When we used propensity score matching method (83 patients from IFN p-1a 44 gg group vs. 83 patients from DMF or fingolimod group), the sustained improvement in observed parameters has persisted before and after change of treatment in both groups but no significant differences were observed between groups. Conclusion: IFN p-1a 44 gg, DMF and fingolimod proved the effectivness in escalation of treatment in the selected group of patients in observed parameters - change of EDSS and time to next relapse). [ABSTRACT FROM AUTHOR]

Aim: To assess retrospectively the clinical efficacy of fingolimod in one or two years of treatment in patients with active multiple sclerosis. Patients and methods: 223 patients were treated with fingolimod for at least one year, 109 of whom were treated for two years. 126 patients were switched to fingolimod from interferon beta or glatiramer acetate, 3 patients were treatment-naive and 94 patients were switched from natalizumab. Results: In patients switched from IFN beta or GA, the relapse rate decreased by 72% in the first year and by 64% in the first 2 years, in patients switched from natalizumab the decrease was 25% in the first year and 31% during 2 years of treatment. 66% of patients in the overall group and in both subgroups remained relapse-free during the first year of treatment and 50.5% over the 2 years of fingolimod treatment. 80% of patients had stable or improved EDSS in the first year and also after 2 years of treatment. 94.6% of patients did not have a 6-months confirmed disability progression within one or 2-year observational period. No evidence of clinical activity of the disease was observed in 64.6% of patients in the first year and in 50% of patients after the first 2 years of treatment. 16.7% of patients with the washout period of 63 days or less after the last infusion of natalizumab relapsed, while the washout period longer than 63 days led to a relapse in 25% of patients. Conclusion: Fingolimod is an effective escalation treatment in patients failing on DMDs or as the first line treatment in patients with high activity of MS. After termination of natalizumab treatment, fingolimod is an effective alternative for the majority of patients. [ABSTRACT FROM AUTHOR]