1. Detection of early pathophysiological changes of breathing in children with chronic respiratory disease
- Author
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Koucký, Václav, Pohunek, Petr, Rybníček, Ondřej, and Chlumský, Jan
- Subjects
airway remodelling ,bazální membrána ,endobronchiální biopsie ,rychlá torakoabdominální komprese ,ventilační odpověď na hyperoxii ,hyperoxia ventilatory response ,bodyplethysmography ,inert gas multiple breath washout test ,funkční vyšetření plic u nespolupracujících dětí ,bodypletysmografie ,infant pulmonary function testing ,tidal volume rapid thoracoabdominal compression ,chronic respiratory diseases ,chronické respirační onemocnění ,reticular basement membrane ,bronchial asthma ,test vícedechového vyplavování inertního plynu z plic ,cystická fibróza ,cystic fibrosis ,remodelace dýchacích cest ,endobronchial biopsy ,asthma bronchiale - Abstract
Detection of early pathophysiological changes of breathing in children with chronic respiratory disease MD. Vaclav Koucky - Ph.D. thesis Abstract Introduction: Currently, there are different methods for infant pulmonary function testing (iPFT) and morphological assessment of microscopic changes in endobronchial biopsy samples (EBB). In research setting, they allow detection of early pathophysiological changes of breathing in small children with chronic respiratory disease, respectively in risk of its development. Their clinical significance, however, is not fully acknowledged. The aim of this thesis is to evaluate the safety, feasibility and clinical significance of iPFT and EBB in infants younger than 2 years of age. In addition, the relationship between functional and morphological changes of respiratory tract and the function of peripheral chemoreceptors was studied in selected patients' subgroups. Methods: Fifty-five infants with cystic fibrosis (CF), 35 physician-confirmed recurrent wheezers (AB), 9 infants with congenital diaphragmatic hernia, 7 with interstitial lung disease (chILD) and 3 with primary ciliary dyskinesia (PCD) were enrolled. All infants underwent iPFT and relevant clinical history data were recorded. Based on patients' age, CF group was divided into CFmalí (< 6 months) and CFvelcí (>...
- Published
- 2020