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Copyright of Medicina Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Neurologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Remedia is the property of Medical Tribune CZ, s.r.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Remedia is the property of Medical Tribune CZ, s.r.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Prophylactic treatment is standard care for most children with severe haemophilia A and maintaining this treatment in adulthood is recommended. However, the situation differs in adult patients with severe haemophilia A previously treated on demand. Between 2008-2015, we performed the following comparison of selected patients with severe haemophilia A. Over one year, we compared the frequency of bleeding episodes in a group of 8 patients aged 20-27, median (average) 22 (22.5) on continued prophylactic treatment from childhood with a group of 8 patients aged 26-65, median (range) 36 (37.5) treated on demand. Meanwhile, this same group was compared after performance of prophylactic treatment. In this group of patients, an individual period of 12 months was chosen and during which a specific patient did not undergo any invasive treatment, or had any serious bleeding episode after injury. Consequently, these patients were observed for another year (12 months), which ideally followed after their switch to prophylactic treatment. A group of patients with severe haemophilia A on prophylactic treatment was included as soon as they had been referred from the Department of Paediatric Haematology University Hospital Brno if they had not undergone in that particular period any invasive treatment or suffered any serious bleeding episode after injury. Patients were selected at a time when not subjected to any invasive procedure or suffering severe bleeding requiring hospitalization. Our results showed that by switching adult patients with frequent bleeding episodes from on demand treatment to prophylactic treatment, bleeding episodes were reduced by 82% (joint bleeds by 79%), without significantly increasing treatment cost. The median (range) of bleeding episodes in the young patient group with ongoing prophylaxis from childhood was 0 (average 0.375) times per year. The median (range) of bleeding joint episodes in older adult patients with on demand treatment was 27.5 (26). The median (range) 3.5 (4.8) number of bleeds decreased significantly with prophylaxis. Secondary prophylaxis in adult patients with severe haemophilia A significantly reduces the frequency of joint bleeds compared with on demand treatment. Prophylactic treatment of adults is certainly advantageous in certain complicated cases of haemophilia. In the future, costly surgery such as orthopaedic interventions could be postponed in these patients. [ABSTRACT FROM AUTHOR]