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CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Author: Štěpánka Vedralová Title of diploma thesis: Formulation and characterization of w/o emulsions for local treatment of musculoskeletal infections Supervisor: PharmDr. Eva Šnejdrová, Ph.D. The aim of the diploma thesis was to formulate a depot dosage form for the prevention and local treatment of musculoskeletal infections. A water-in-oil emulsions have been formulated which, due to the partition coefficient between the outer and inner phases, can provide sustained drug release. Oils with different viscosities were tested as oil phases. Tricaprin was chosen for the preparation of emulsions, due to the highest stability of the prepared emulsion. Lecithin and sorbitan monooleate or polyglyceryl-3-polyricinooleate (PGPR) and magnesium stearate were used as emulsifiers. The aqueous phase was a solution of vancomycin hydrochloride and gentamicin sulphate. The flow properties on a rotational rheometer were evaluated. The influence of the emulsion composition and the homogenization method on the coefficient of consistency and the index of flow behaviour of the emulsions was studied. The emulsions stabilized with lecithin have a higher viscosity and a structure more sensitive to changes in composition...

Children are a susceptible group to environment pollution. The environment, in which they spend the most time, is the home, the second is the school. Therefore, the indoor environment of a school affects their health, wellbeing and even school results. The present work investigated concentrations of air pollutant, aerosol particles, in the specialized classrooms (computer lab, arts and biology/chemistry) in an elementary school, Prague. Direct reading instruments measuring mass concentration of four aerosol fractions and number concentration of submicrometer particles were used for measurement. Measurements were carried out for four weekdays in each month from November 2011 to July 2012. It was found that mass concentrations of submicrometer particles were dependent on outdoor concentrations, in contrast to supermicrometer particles which were affected mainly by physical activities of students and outdoor concentration had a minimal effect. Increased number concentrations of submicrometer particles were observed only during children presence, concentrations were probably induced by student activities during lessons. Seasons also influenced mass concentrations, when the highest indoor and outdoor concentrations were recorded in a spring/autumn season. Classroom location affected submicrometer...