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Epidemiological datas describing up to date status of diagnostics and oncological parameters (incidence, mortality, prevalence, total number of pacients with breast cancer) are given in the article. Further changes are comented in this field after start of mammografic screening programme in our country in the year 2002. Authors evaluated possibilities of clinical diagnostics performed by mammologist in his ambulance and possibilities and types of invasive and noninvasive (immaging) diagnostic methods performed by radiodiagnostic according mammologist indication. Management of benign and malignant leasions detected and treated in the mammological centre of the University Hospital Královské Vinohrady are mentioned.