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Start Over Descriptor "MGUS" Language czech
2 results on '"MGUS"'

1. Osteolytic bone lesions, hypercalcemia and paraprotein, but not a myeloma: case report and review of literature.

Author

Hradská K, Jelínek T, Ďuraš J, Mihályová J, Popková T, Cvek J, Bukovanský K, Havel M, Spáčilová V, and Hájek R

Subjects
Aged, Humans, Male, Paraproteins, Hypercalcemia complications, Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma complications, Multiple Myeloma diagnosis, Paraproteinemias
Abstract

In June 2018, 77-year-old man was referred to The Department of Haematooncology, University Hospital Ostrava, for suspicion of multiple myeloma. This was supported by laboratory findings of hypercalcemia, paraprotein IgA κ in serum and by the presence of multiple osteolytic skeletal lesions. Low number of plasma cells in bone marrow sample - cytologically (3.6 %) as well as in flow cytometry (less than 95 % clonal plasma cells out of total bone marrow plasma cells) - pointed at the direction of monoclonal gammopathy of undetermined significance (MGUS). In the course of differential diagnosis of hypercalcemia, elevated level of parathormone had been found which led to the performance of 99mTc-MIBI scintigraphy where parathyroid adenoma was discovered and later histologically verified. The final diagnosis was determined as a coincidence of MGUS and primary hyperparathyroidism. This case report also contains brief differential diagnosis of hypercalcemia and osteolytic skeletal lesions and suggestions for their diagnostic algorithms.

Published
2020

2. Hyperviscosity Syndrome in Patiens with Monoclonal Gammopathy

Author

Vaňková, Radka, Fátorová, Ilona, and Vrbacký, Filip

Subjects
MGUS, viscosity, multiple myeloma, Monoclonal gammopathy, mnohočetný myelom, hyperviskózní syndrom, viskozita, Waldenström's macroglobulinemia, hyperviscosity syndrome, Waldenströmova makroglobulinémie, Monoklonální gamapatie
Abstract

The thesis deals with the assessment of correlations between selected laboratory parameters used in the diagnosis hyperviscosity syndrome and the determination of monoclonal immunoglobulin. By means of specific examples is graphically illustrated the effect of therapeutic plasmapheresis on laboratory parameters and the clinical condition of the patient. The thesis is divided into theoretical and practical parts. In the theoretical part are summarized the findings of the diagnosis, clinical manifestations and therapeutic methods of hyperviscosity syndrome. Further the history of monoclonal gammopathies is stated with splitting in two basic groups. Within the group of malignant monoclonal gammopathies are described in detail two diseases that are closely related to hyperviscosity syndrome. The first is Waldenström's macroglobulinemia and the second is multiple myeloma. In both diseases is shown their prevalence, definition, etiology, pathophysiology, laboratory findings and clinical symptoms. Further are briefly described methods used for determination of monoclonal immunoglobulin. The practical part describes the laboratory tests, which were obtained laboratory data of the reference group of patients. Laboratory data were processed by regression in Microsoft Office Excel 2007. A statistically...

Published
2014

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