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The authors present a case of 61-year-old man with ulcerative colitis and with extraintestinal manifestation of the disease in the form of pyoderma gangraenosum. Multiple skin defects, which developed in atypical localisation (extensive affection of facial and hairy parts of the head) in patient with chronically active form of ulcerative colitis were complicated with bacterial contamination of methicilin-resistant strains of Staphylococcus aureus. After application of the parenteral feeding, corticotherapy and targeted antibiotic therapy the subjective and objective status of the patient markedly improved, stool frequency was reduced, admixture of blood in the stool disappeared, temperatures fell back and there was a decrease in activity of non-specific bowel inflammation in laboratory findings. However endoscopic examination of the intestine confirmed the finding of chronically active ulcerative colitis with ulcerations and bridging polyps. Patient was indicated to total colectomy, but he refused it.

A 9-month-old boy with impetigious blepharitis of the right eye was admitted to the Department of children and adolescents of the Kralovske Vinohrady University Hospital. NA isolated from lesion fluid was screened using real-time PCR based HSV 1/2 detection kit (Roche). Differentiation between HSV types 1 and 2 in this assay is based on variation of double-stranded DNA melting temperature (Tm), being 54 degrees C +/- 2,5 degrees C for HSV-1 and 66,5 degrees C +/- 2,5 degrees C for HSV-2. Since the amplified NA from the sample showed an atypical Tm of 59 degrees C, nested PCR was used for futher analysis: the presence of HSV-1 NA was confirmed by the latter. In spite of the atypical Tm value, the eyelid infection was responsive to acyclovir and resolved after intravenous Herpesin given for 5 days.

The authors present an account on results of CO2 laser therapy in facial skin and conjunctival affections during the period between 1990 and 1993. In the evaluated group, comprising 60 patients with an observation period of 18 months, this method was used 82 times, incl. four where it was used repeatedly. In the technique of the procedure simple vaporization markedly predominates over combined operations or laser incisions (continual regime). The defect after vaporization heals by tissue which has the same colour as surrounding skin, in a very small minority with slight local depigmentation without a tendency of major scarring and with a satisfactory cosmetic effect. The authors discuss indications of CO2 lasers in ophthalmology. The method is recommended in strictly defined affections of the skin and conjunctivae.

Authors describe two cases of computer operators (female subjects) which experienced face skin disorders in connection with computer's terminal staffing. The first case was concerned with acute worsening of seborrheic dermatitis, the second one with photosensitive reaction complicated partially by psychogenic erythema.