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The publication deals with a brief summarizing the results of a working group of EFLM for biological variation studies (Eu- BIVAS). There are described namely calculations of within- and between subject biological variation and their applications for calculation of analytical quality criteria (APS values) and for calculation of significance of reference changes values as potency for monitoring of the patient´s state. We described EFLM biological variation database. We also show the necessity of biological variation for personalized medicine and individualized approach to laboratory results (individual reference intervals, machine learning). [ABSTRACT FROM AUTHOR]

At the turn of the 19th and 20th centuries, 54 Przewalski's horses were imported alive to Europe in five transports. Only twelve of them (6 ♂♂, 6 ♀♀) have bred. The earliest birth occurred in a mare at the age of five years and the oldest mare gave birth at the age of 17 years, always during the period from spring to autumn. The most fertile stallion was a father of ten foals and the most fertile mare gave birth to eight foals. Longevity was relatively high; three stallions reached the age over 20 years, the oldest one of 28 years. Cadavers of individuals imported from nature and registered in the pedigree-book are listed, they represent less than a half of all registered individuals officially imported to Europe. [ABSTRACT FROM AUTHOR]