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Bovine mastitis is the most common disease and has greatly affected economies around the world. This study aimed to determine the antibacterial ability of bovine mastitis by curcumin - silver nanoparticles (Cur-AgNPs). The study included experiments on presenting a new process for synthesizing silver nanoparticles using curcumin from fresh turmeric as a reducing agent and stabilizer. UV-visible spectroscopy of the samples revealed the localized surface plasmon resonance absorbance of the dispersion of silver nanoparticles at 430 nm. The prepared Cur-AgNPs has a spherical shape with an average size of 30 nm and a size distribution of 15–47 nm. FT-IR (Fourier transform infrared spectroscopy) measurements of the samples showed that silver nanopartilces has been encapsulated well by curcumin. Cur-AgNPs with a concentration of 50-200 μg/mL has very effect to Staphylococcus aureus, Pseudomonas aeruginosa causing bovine mastitis in vitro. The maximum inhibition zone formed was 15 ± 0.85 mm for Staphylococcus aureus and 14 ± 0.56 mm for Pseudomonas aeruginosa. Plant materials mediating for the synthesis of silver nanoparticles have relatively rapid, less expensive, and widespread applications for antimicrobial therapy in the livestock sector.